β-Arrestin–Biased Angiotensin II Receptor Agonists for COVID-19

por Manglik, Aashish, Wingler, Laura M., Rockman, Howard A., Lefkowitz, Robert J.
Publicado 2020

Structure of the M2 muscarinic receptor-β-arrestin complex in a lipid nanodisc

por Staus, Dean P., Hu, Hongli, Robertson, Michael J., Kleinhenz, Alissa L. W., Wingler, Laura M., Capel, William D., Latorraca, Naomi R., Lefkowitz, Robert J., Skiniotis, Georgios
Publicado 2020

Antibodies Expand the Scope of Angiotensin Receptor Pharmacology

por Skiba, Meredith A., Sterling, Sarah M., Rawson, Shaun, Gilman, Morgan S.A., Xu, Huixin, Nemeth, Genevieve R., Hurley, Joseph D., Shen, Pengxiang, Staus, Dean P., Kim, Jihee, McMahon, Conor, Lehtinen, Maria K., Wingler, Laura M., Kruse, Andrew C.
Publicado 2023

Allosteric Nanobodies Reveal the Dynamic Range and Diverse Mechanisms of GPCR Activation

por Staus, Dean P, Strachan, Ryan T, Manglik, Aashish, Pani, Biswaranjan, Kahsai, Alem W, Kim, Tae Hun, Wingler, Laura M, Ahn, Seungkirl, Chatterjee, Arnab, Masoudi, Ali, Kruse, Andrew C, Pardon, Els, Steyaert, Jan, Weis, William I, Prosser, R. Scott, Kobilka, Brian K, Costa, Tommaso, Lefkowitz, Robert J
Publicado 2016

Discovery of β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor

por Aristotelous, Tonia, Ahn, Seungkirl, Shukla, Arun K., Gawron, Sylwia, Sassano, Maria F., Kahsai, Alem W., Wingler, Laura M., Zhu, Xiao, Tripathi-Shukla, Prachi, Huang, Xi-Ping, Riley, Jennifer, Besnard, Jérémy, Read, Kevin D., Roth, Bryan L., Gilbert, Ian H., Hopkins, Andrew L., Lefkowitz, Robert J., Navratilova, Iva
Publicado 2013

Conformationally Selective RNA Aptamers Allosterically Modulate the β(2)-Adrenoceptor

por Kahsai, Alem W., Wisler, James W., Lee, Jungmin, Ahn, Seungkirl, Cahill, Thomas J., Dennison, S. Moses, Staus, Dean P., Thomsen, Alex R. B., Anasti, Kara M., Pani, Biswaranjan, Wingler, Laura M., Desai, Hemant, Bompiani, Kristin M., Strachan, Ryan T., Qin, Xiaoxia, Alam, S. Munir, Sullenger, Bruce A., Lefkowitz, Robert J.
Publicado 2016

Small-Molecule Positive Allosteric Modulators of the β(2)-Adrenoceptor Isolated from DNA-Encoded Libraries

por Ahn, Seungkirl, Pani, Biswaranjan, Kahsai, Alem W., Olsen, Eva K., Husemoen, Gitte, Vestergaard, Mikkel, Jin, Lei, Zhao, Shuai, Wingler, Laura M., Rambarat, Paula K., Simhal, Rishabh K., Xu, Thomas T., Sun, Lillian D., Shim, Paul J., Staus, Dean P., Huang, Li-Yin, Franch, Thomas, Chen, Xin, Lefkowitz, Robert J.
Publicado 2018