Dimeric quinacrines as chemical tools to identify PPT1, a new regulator of autophagy in cancer cells

por Nicastri, Michael C., Rebecca, Vito W., Amaravadi, Ravi K., Winkler, Jeffrey D.
Publicado 2017

The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate

por Nishimura, Yorihiro, McLaughlin, Noel P., Pan, Jieyan, Goldstein, Sara, Hafenstein, Susan, Shimizu, Hiroyuki, Winkler, Jeffrey D., Bergelson, Jeffrey M.
Publicado 2015

A Potent Autophagy Inhibitor (Lys05) Enhances the Impact of Ionizing Radiation on Human Lung Cancer Cells H1299

por Cechakova, Lucie, Ondrej, Martin, Pavlik, Vojtech, Jost, Petr, Cizkova, Dana, Bezrouk, Ales, Pejchal, Jaroslav, Amaravadi, Ravi K., Winkler, Jeffrey D., Tichy, Ales
Publicado 2019

Sex steroids regulate skin pigmentation through nonclassical membrane-bound receptors

por Natale, Christopher A, Duperret, Elizabeth K, Zhang, Junqian, Sadeghi, Rochelle, Dahal, Ankit, O'Brien, Kevin Tyler, Cookson, Rosa, Winkler, Jeffrey D, Ridky, Todd W
Publicado 2016

Autophagy supports generation of cells with high CD44 expression via modulation of oxidative stress and Parkin-mediated mitochondrial clearance

por Whelan, Kelly A., Chandramouleeswaran, Prasanna M., Tanaka, Koji, Natsuizaka, Mitsuteru, Guha, Manti, Srinivasan, Satish, Darling, Douglas S., Kita, Yoshiaki, Natsugoe, Shoji, Winkler, Jeffrey D., Klein-Szanto, Andres J., Amaravadi, Ravi K., Avadhani, Narayan G., Rustgi, Anil. K, Nakagawa, Hiroshi
Publicado 2017

CDK4/6 and autophagy inhibitors synergistically induce senescence in Rb positive cytoplasmic cyclin E negative cancers

por Vijayaraghavan, Smruthi, Karakas, Cansu, Doostan, Iman, Chen, Xian, Bui, Tuyen, Yi, Min, Raghavendra, Akshara S., Zhao, Yang, Bashour, Sami I., Ibrahim, Nuhad K., Karuturi, Meghan, Wang, Jing, Winkler, Jeffrey D., Amaravadi, Ravi K., Hunt, Kelly K., Tripathy, Debu, Keyomarsi, Khandan
Publicado 2017

SIRT1 is downregulated by autophagy in senescence and aging

por Xu, Caiyue, Wang, Lu, Fozouni, Parinaz, Evjen, Gry, Chandra, Vemika, Jiang, Jing, Lu, Congcong, Nicastri, Michael, Bretz, Corey, Winkler, Jeffrey D., Amaravadi, Ravi, Garcia, Benjamin A., Adams, Peter D., Ott, Melanie, Tong, Wei, Johansen, Terje, Dou, Zhixun, Berger, Shelley L.
Publicado 2020

Lysosomal lipid peroxidation regulates tumor immunity

por Bhardwaj, Monika, Lee, Jennifer J., Versace, Amanda M., Harper, Sandra L., Goldman, Aaron R., Crissey, Mary Ann S., Jain, Vaibhav, Singh, Mahendra Pal, Vernon, Megane, Aplin, Andrew E., Lee, Seokwoo, Morita, Masao, Winkler, Jeffrey D., Liu, Qin, Speicher, David W., Amaravadi, Ravi K.
Publicado 2023

Targeting quiescent leukemic stem cells using second generation autophagy inhibitors

por Baquero, Pablo, Dawson, Amy, Mukhopadhyay, Arunima, Kuntz, Elodie M., Mitchell, Rebecca, Olivares, Orianne, Ianniciello, Angela, Scott, Mary T., Dunn, Karen, Nicastri, Michael C., Winkler, Jeffrey D., Michie, Alison M., Ryan, Kevin M., Halsey, Christina, Gottlieb, Eyal, Keaney, Erin P., Murphy, Leon O., Amaravadi, Ravi K., Holyoake, Tessa L., Helgason, G. Vignir
Publicado 2018

PPT1 inhibition enhances the antitumor activity of anti–PD-1 antibody in melanoma

por Sharma, Gaurav, Ojha, Rani, Noguera-Ortega, Estela, Rebecca, Vito W., Attanasio, John, Liu, Shujing, Piao, Shengfu, Lee, Jennifer J., Nicastri, Michael C., Harper, Sandra L., Ronghe, Amruta, Jain, Vaibhav, Winkler, Jeffrey D., Speicher, David W., Mastio, Jerome, Gimotty, Phyllis A., Xu, Xiaowei, Wherry, E. John, Gabrilovich, Dmitry I., Amaravadi, Ravi K.
Publicado 2020

PPT1 inhibition enhances the antitumor activity of anti–PD-1 antibody in melanoma

por Sharma, Gaurav, Ojha, Rani, Noguera-Ortega, Estela, Rebecca, Vito W., Attanasio, John, Liu, Shujing, Piao, Shengfu, Lee, Jennifer J., Nicastri, Michael C., Harper, Sandra L., Ronghe, Amruta, Jain, Vaibhav, Winkler, Jeffrey D., Speicher, David W., Mastio, Jerome, Gimotty, Phyllis A., Xu, Xiaowei, Wherry, E. John, Gabrilovich, Dmitry I., Amaravadi, Ravi K.
Publicado 2022