Opportunities and perspectives for developing orexin receptor antagonists

por Steiner, Michel A., Winrow, Christopher J.
Publicado 2014

First‐in‐human trial to assess safety, tolerability, pharmacokinetics, and pharmacodynamics of zagociguat (CY6463), a CNS‐penetrant soluble guanylyl cyclase stimulator

por van Kraaij, Sebastiaan J. W., Gal, Pim, Borghans, Laura G. J. M., Klaassen, Erica S., Dijkstra, Francis, Winrow, Christopher, Glasser, Chad, Groeneveld, Geert Jan
Publicado 2023

Quantitative Proteomics in Laser Capture Microdissected Sleep Nuclei From Rat Brain

por Miller, Ronald A., Winrow, Christopher J., Spellman, Daniel S., Song, Qinghua, Reiss, Duane R., Conway, James P., Taylor, Rhonda R., Coleman, Paul J., Hendrickson, Ronald C., Renger, John J.
Publicado 2014

Cross-species systems analysis identifies gene networks differentially altered by sleep loss and depression

por Scarpa, Joseph R., Jiang, Peng, Gao, Vance D., Fitzpatrick, Karrie, Millstein, Joshua, Olker, Christopher, Gotter, Anthony, Winrow, Christopher J., Renger, John J., Kasarskis, Andrew, Turek, Fred W., Vitaterna, Martha H.
Publicado 2018

Phelan-McDermid syndrome: a classification system after 30 years of experience

por Phelan, Katy, Boccuto, Luigi, Powell, Craig M., Boeckers, Tobias M., van Ravenswaaij-Arts, Conny, Rogers, R. Curtis, Sala, Carlo, Verpelli, Chiara, Thurm, Audrey, Bennett, William E., Winrow, Christopher J., Garrison, Sheldon R., Toro, Roberto, Bourgeron, Thomas
Publicado 2022

Orexin receptor antagonist-induced sleep does not impair the ability to wake in response to emotionally salient acoustic stimuli in dogs

por Tannenbaum, Pamela L., Stevens, Joanne, Binns, Jacquelyn, Savitz, Alan T., Garson, Susan L., Fox, Steven V., Coleman, Paul, Kuduk, Scott D., Gotter, Anthony L., Marino, Michael, Tye, Spencer J., Uslaner, Jason M., Winrow, Christopher J., Renger, John J.
Publicado 2014

Differential sleep-promoting effects of dual orexin receptor antagonists and GABA(A) receptor modulators

por Gotter, Anthony L, Garson, Susan L, Stevens, Joanne, Munden, Regina L, Fox, Steven V, Tannenbaum, Pamela L, Yao, Lihang, Kuduk, Scott D, McDonald, Terrence, Uslaner, Jason M, Tye, Spencer J, Coleman, Paul J, Winrow, Christopher J, Renger, John J
Publicado 2014

The CNS-penetrant soluble guanylate cyclase stimulator CYR119 attenuates markers of inflammation in the central nervous system

por Correia, Susana S., Liu, Guang, Jacobson, Sarah, Bernier, Sylvie G., Tobin, Jenny V., Schwartzkopf, Chad D., Atwater, Emily, Lonie, Elisabeth, Rivers, Sam, Carvalho, Andrew, Germano, Peter, Tang, Kim, Iyengar, Rajesh R., Currie, Mark G., Hadcock, John R., Winrow, Christopher J., Jones, Juli E.
Publicado 2021

Uncovering the Genetic Landscape for Multiple Sleep-Wake Traits

por Winrow, Christopher J., Williams, Deanna L., Kasarskis, Andrew, Millstein, Joshua, Laposky, Aaron D., Yang, He S., Mrazek, Karrie, Zhou, Lili, Owens, Joseph R., Radzicki, Daniel, Preuss, Fabian, Schadt, Eric E., Shimomura, Kazuhiro, Vitaterna, Martha H., Zhang, Chunsheng, Koblan, Kenneth S., Renger, John J., Turek, Fred W.
Publicado 2009

Dual orexin receptor antagonists show distinct effects on locomotor performance, ethanol interaction and sleep architecture relative to gamma-aminobutyric acid-A receptor modulator...

por Ramirez, Andres D., Gotter, Anthony L., Fox, Steven V., Tannenbaum, Pamela L., Yao, Lihang, Tye, Spencer J., McDonald, Terrence, Brunner, Joseph, Garson, Susan L., Reiss, Duane R., Kuduk, Scott D., Coleman, Paul J., Uslaner, Jason M., Hodgson, Robert, Browne, Susan E., Renger, John J., Winrow, Christopher J.
Publicado 2013

The CNS-Penetrant Soluble Guanylate Cyclase Stimulator CY6463 Reveals its Therapeutic Potential in Neurodegenerative Diseases

por Correia, Susana S., Iyengar, Rajesh R., Germano, Peter, Tang, Kim, Bernier, Sylvie G., Schwartzkopf, Chad D., Tobin, Jenny, Lee, Thomas W.-H., Liu, Guang, Jacobson, Sarah, Carvalho, Andrew, Rennie, Glen R., Jung, Joon, Renhowe, Paul A., Lonie, Elisabeth, Winrow, Christopher J., Hadcock, John R., Jones, Juli E., Currie, Mark G.
Publicado 2021

Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to Man

por Gotter, Anthony L., Forman, Mark S., Harrell, Charles M., Stevens, Joanne, Svetnik, Vladimir, Yee, Ka Lai, Li, Xiaodong, Roecker, Anthony J., Fox, Steven V., Tannenbaum, Pamela L., Garson, Susan L., Lepeleire, Inge De, Calder, Nicole, Rosen, Laura, Struyk, Arie, Coleman, Paul J., Herring, W. Joseph, Renger, John J., Winrow, Christopher J.
Publicado 2016

The duration of sleep promoting efficacy by dual orexin receptor antagonists is dependent upon receptor occupancy threshold

por Gotter, Anthony L, Winrow, Christopher J, Brunner, Joseph, Garson, Susan L, Fox, Steven V, Binns, Jacquelyn, Harrell, Charles M, Cui, Donghui, Yee, Ka Lai, Stiteler, Mark, Stevens, Joanne, Savitz, Alan, Tannenbaum, Pamela L, Tye, Spencer J, McDonald, Terrence, Yao, Leon, Kuduk, Scott D, Uslaner, Jason, Coleman, Paul J, Renger, John J
Publicado 2013