Brucella suis carbonic anhydrases and their inhibitors: Towards alternative antibiotics?

por Köhler, Stephan, Ouahrani-Bettache, Safia, Winum, Jean-Yves
Publicado 2017

Multivalent Carbonic Anhydrases Inhibitors †

por Carta, Fabrizio, Dumy, Pascal, Supuran, Claudiu T., Winum, Jean-Yves
Publicado 2019

Recent Developments in Targeting Carbonic Anhydrase IX for Cancer Therapeutics

por McDonald, Paul C., Winum, Jean-Yves, Supuran, Claudiu T., Dedhar, Shoukat
Publicado 2012

Carbonic anhydrases from Trypanosoma cruzi and Leishmania donovani chagasi are inhibited by benzoxaboroles

por Nocentini, Alessio, Cadoni, Roberta, Dumy, Pascal, Supuran, Claudiu T., Winum, Jean-Yves
Publicado 2017

(Hetero)aryl substituted thiazol-2,4-yl scaffold as human carbonic anhydrase I, II, VII and XIV activators

por Rami, Marouan, Winum, Jean-Yves, Supuran, Claudiu T., Melnyk, Patricia, Yous, Saïd
Publicado 2019

tert-Butyl N-[N,N-bis­(2-chloro­ethyl)sulfamo­yl]-N-(2-chloro­ethyl)carbamate

por Seridi, Achour, Akkari, Hocine, Winum, Jean-Yves, Bénard-Rocherullé, Patricia, Abdaoui, Mohamed
Publicado 2009

Carbonic Anhydrase Inhibitors as Novel Drugs against Mycobacterial β-Carbonic Anhydrases: An Update on In Vitro and In Vivo Studies

por Aspatwar, Ashok, Winum, Jean-Yves, Carta, Fabrizio, Supuran, Claudiu T., Hammaren, Milka, Parikka, Mataleena, Parkkila, Seppo
Publicado 2018

Insights into the binding mode of sulphamates and sulphamides to hCA II: crystallographic studies and binding free energy calculations

por De Simone, Giuseppina, Langella, Emma, Esposito, Davide, Supuran, Claudiu T., Monti, Simona Maria, Winum, Jean-Yves, Alterio, Vincenzo
Publicado 2017

Novel Re(I) tricarbonyl coordination compounds based on 2-pyridyl-1,2,3-triazole derivatives bearing a 4-amino-substituted benzenesulfonamide arm: synthesis, crystal structure, com...

por Aimene, Yassine, Eychenne, Romain, Mallet-Ladeira, Sonia, Saffon, Nathalie, Winum, Jean-Yves, Nocentini, Alessio, Supuran, Claudiu T., Benoist, Eric, Seridi, Achour
Publicado 2019

Design, synthesis, in vitro inhibition and toxicological evaluation of human carbonic anhydrases I, II and IX inhibitors in 5-nitroimidazole series

por Aspatwar, Ashok, Parvathaneni, Nanda Kumar, Barker, Harlan, Anduran, Emilie, Supuran, Claudiu T., Dubois, Ludwig, Lambin, Philippe, Parkkila, Seppo, Winum, Jean-Yves
Publicado 2019

A Novel Inhibitor of Carbonic Anhydrases Prevents Hypoxia-Induced TNBC Cell Plasticity

por Sarnella, Annachiara, D’Avino, Giuliana, Hill, Billy Samuel, Alterio, Vincenzo, Winum, Jean-Yves, Supuran, Claudiu T., De Simone, Giuseppina, Zannetti, Antonella
Publicado 2020

Reconsidering anion inhibitors in the general context of drug design studies of modulators of activity of the classical enzyme carbonic anhydrase

por Nocentini, Alessio, Angeli, Andrea, Carta, Fabrizio, Winum, Jean-Yves, Zalubovskis, Raivis, Carradori, Simone, Capasso, Clemente, Donald, William A., Supuran, Claudiu T.
Publicado 2021

Exploring benzoxaborole derivatives as carbonic anhydrase inhibitors: a structural and computational analysis reveals their conformational variability as a tool to increase enzyme...

por Langella, Emma, Alterio, Vincenzo, D’Ambrosio, Katia, Cadoni, Roberta, Winum, Jean-Yves, Supuran, Claudiu T., Monti, Simona Maria, De Simone, Giuseppina, Di Fiore, Anna
Publicado 2019

Hypoxia-Activated Prodrug Derivatives of Carbonic Anhydrase Inhibitors in Benzenesulfonamide Series: Synthesis and Biological Evaluation

por Anduran, Emilie, Aspatwar, Ashok, Parvathaneni, Nanda-Kumar, Suylen, Dennis, Bua, Silvia, Nocentini, Alessio, Parkkila, Seppo, Supuran, Claudiu T., Dubois, Ludwig, Lambin, Philippe, Winum, Jean-Yves
Publicado 2020

Targeting the Human 80S Ribosome in Cancer: From Structure to Function and Drug Design for Innovative Adjuvant Therapeutic Strategies

por Gilles, Arnaud, Frechin, Léo, Natchiar, Kundhavai, Biondani, Giulia, von Loeffelholz, Ottilie, Holvec, Samuel, Malaval, Julie-Lisa, Winum, Jean-Yves, Klaholz, Bruno P., Peyron, Jean-François
Publicado 2020

Nitroimidazole-based inhibitors DTP338 and DTP348 are safe for zebrafish embryos and efficiently inhibit the activity of human CA IX in Xenopus oocytes

por Aspatwar, Ashok, Becker, Holger M., Parvathaneni, Nanda Kumar, Hammaren, Milka, Svorjova, Aleksandra, Barker, Harlan, Supuran, Claudiu T., Dubois, Ludwig, Lambin, Philippe, Parikka, Mataleena, Parkkila, Seppo, Winum, Jean-Yves
Publicado 2018

Binding of Carbonic Anhydrase IX to 45S rDNA Genes Is Prevented by Exportin-1 in Hypoxic Cells

por Sasso, Emanuele, Vitale, Monica, Monteleone, Francesca, Boffo, Francesca Ludovica, Santoriello, Margherita, Sarnataro, Daniela, Garbi, Corrado, Sabatella, Mariangela, Crifò, Bianca, Paolella, Luca Alfredo, Minopoli, Giuseppina, Winum, Jean-Yves, Zambrano, Nicola
Publicado 2015

Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment

por Angeli, Andrea, Carta, Fabrizio, Nocentini, Alessio, Winum, Jean-Yves, Zalubovskis, Raivis, Akdemir, Atilla, Onnis, Valentina, Eldehna, Wagdy M., Capasso, Clemente, Simone, Giuseppina De, Monti, Simona Maria, Carradori, Simone, Donald, William A., Dedhar, Shoukat, Supuran, Claudiu T.
Publicado 2020

Evaluation of carbonic anhydrase IX as a therapeutic target for inhibition of breast cancer invasion and metastasis using a series of in vitro breast cancer models

por Ward, Carol, Meehan, James, Mullen, Peter, Supuran, Claudiu, Dixon, J. Michael, Thomas, Jeremy S., Winum, Jean-Yves, Lambin, Philippe, Dubois, Ludwig, Pavathaneni, Nanda-Kumar, Jarman, Edward J., Renshaw, Lorna, Um, InHwa, Kay, Charlene, Harrison, David J., Kunkler, Ian H., Langdon, Simon P.
Publicado 2015

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–6

por Vanden Eynde, Jean Jacques, Mangoni, Arduino A., Rautio, Jarkko, Leprince, Jérôme, Azuma, Yasu-Taka, García-Sosa, Alfonso T., Hulme, Christopher, Jampilek, Josef, Karaman, Rafik, Li, Wei, Gomes, Paula A. C., Hadjipavlou-Litina, Dimitra, Capasso, Raffaele, Geronikaki, Athina, Cerchia, Laura, Sabatier, Jean-Marc, Ragno, Rino, Tuccinardi, Tiziano, Trabocchi, Andrea, Winum, Jean-Yves, Luque, F. Javier, Prokai-Tatrai, Katalin, Spetea, Mariana, Gütschow, Michael, Kosalec, Ivan, Guillou, Catherine, Vasconcelos, M. Helena, Kokotos, George, Rastelli, Giulio, de Sousa, Maria Emília, Manera, Clementina, Gemma, Sandra, Mangani, Stefano, Siciliano, Carlo, Galdiero, Stefania, Liu, Hong, Scott, Peter J. H., de los Ríos, Cristóbal, Agrofoglio, Luigi A., Collina, Simona, Guedes, Rita C., Muñoz-Torrero, Diego
Publicado 2019