Rodent Modeling of Alzheimer's Disease in Down Syndrome: In vivo and ex vivo Approaches

por Farrell, Clíona, Mumford, Paige, Wiseman, Frances K.
Publicado 2022

Cell models for Down syndrome-Alzheimer’s disease research

por Wu, Yixing, West, Nicole R., Bhattacharyya, Anita, Wiseman, Frances K.
Publicado 2022

Down syndrome—recent progress and future prospects

por Wiseman, Frances K., Alford, Kate A., Tybulewicz, Victor L.J., Fisher, Elizabeth M.C.
Publicado 2009

Mouse Models of Aneuploidy

por Sheppard, Olivia, Wiseman, Frances K., Ruparelia, Aarti, Tybulewicz, Victor L. J., Fisher, Elizabeth M. C.
Publicado 2012

Generation of a panel of antibodies against proteins encoded on human chromosome 21

por Wiseman, Frances K, Sheppard, Olivia, Linehan, Jacqueline M, Brandner, Sebastian, Tybulewicz, Victor LJ, Fisher, Elizabeth MC
Publicado 2010

Endosomal structure and APP biology are not altered in a preclinical mouse cellular model of Down syndrome

por Cannavo, Claudia, Cleverley, Karen, Maduro, Cheryl, Mumford, Paige, Moulding, Dale, Fisher, Elizabeth M. C., Wiseman, Frances K.
Publicado 2022

The effects of Cstb duplication on APP/amyloid-β pathology and cathepsin B activity in a mouse model

por Wu, Yixing, Whittaker, Heather T., Noy, Suzanna, Cleverley, Karen, Brault, Veronique, Herault, Yann, Fisher, Elizabeth M. C., Wiseman, Frances K.
Publicado 2021

Tc1 mouse model of trisomy-21 dissociates properties of short- and long-term recognition memory

por Hall, Jessica H., Wiseman, Frances K., Fisher, Elizabeth M.C., Tybulewicz, Victor L.J., Harwood, John L., Good, Mark A.
Publicado 2016

Protein profiles in Tc1 mice implicate novel pathway perturbations in the Down syndrome brain

por Ahmed, Md. Mahiuddin, Dhanasekaran, A. Ranjitha, Tong, Suhong, Wiseman, Frances K., Fisher, Elizabeth M.C., Tybulewicz, Victor L.J., Gardiner, Katheleen J.
Publicado 2013

The Glycosylation Status of PrP(C) Is a Key Factor in Determining Transmissible Spongiform Encephalopathy Transmission between Species

por Wiseman, Frances K., Cancellotti, Enrico, Piccardo, Pedro, Iremonger, Kayleigh, Boyle, Aileen, Brown, Deborah, Ironside, James W., Manson, Jean C., Diack, Abigail B.
Publicado 2015

Cathepsin B abundance, activity and microglial localisation in Alzheimer’s disease-Down syndrome and early onset Alzheimer’s disease; the role of elevated cystatin B

por Wu, Yixing, Mumford, Paige, Noy, Suzanna, Cleverley, Karen, Mrzyglod, Alicja, Luo, Dinghao, van Dalen, Floris, Verdoes, Martijn, Fisher, Elizabeth M. C., Wiseman, Frances K.
Publicado 2023

Altered regulation of tau phosphorylation in a mouse model of down syndrome aging

por Sheppard, Olivia, Plattner, Florian, Rubin, Anna, Slender, Amy, Linehan, Jacqueline M., Brandner, Sebastian, Tybulewicz, Victor L.J., Fisher, Elizabeth M.C., Wiseman, Frances K.
Publicado 2012

The integration site of the APP transgene in the J20 mouse model of Alzheimer’s disease

por Tosh, Justin L., Rickman, Matthew, Rhymes, Ellie, Norona, Frances E., Clayton, Emma, Mucke, Lennart, Isaacs, Adrian M., Fisher, Elizabeth M.C., Wiseman, Frances K.
Publicado 2018

Plasma biomarkers for amyloid, tau, and cytokines in Down syndrome and sporadic Alzheimer’s disease

por Startin, Carla M., Ashton, Nicholas J., Hamburg, Sarah, Hithersay, Rosalyn, Wiseman, Frances K., Mok, Kin Y., Hardy, John, Lleó, Alberto, Lovestone, Simon, Parnetti, Lucilla, Zetterberg, Henrik, Hye, Abdul, Strydom, André
Publicado 2019

Altered Hippocampal-Prefrontal Neural Dynamics in Mouse Models of Down Syndrome

por Chang, Pishan, Bush, Daniel, Schorge, Stephanie, Good, Mark, Canonica, Tara, Shing, Nathanael, Noy, Suzanna, Wiseman, Frances K., Burgess, Neil, Tybulewicz, Victor L.J., Walker, Matthew C., Fisher, Elizabeth M.C.
Publicado 2020

Structural correlates of active-staining following magnetic resonance microscopy in the mouse brain

por Cleary, Jon O., Wiseman, Frances K., Norris, Francesca C., Price, Anthony N., Choy, ManKin, Tybulewicz, Victor L.J., Ordidge, Roger J., Brandner, Sebastian, Fisher, Elizabeth M.C., Lythgoe, Mark F.
Publicado 2011

Genetic dissection of down syndrome-associated alterations in APP/amyloid-β biology using mouse models

por Tosh, Justin L., Rhymes, Elena R., Mumford, Paige, Whittaker, Heather T., Pulford, Laura J., Noy, Sue J., Cleverley, Karen, Walker, Matthew C., Tybulewicz, Victor L. J., Wykes, Rob C., Fisher, Elizabeth M. C., Wiseman, Frances K.
Publicado 2021

Publisher Correction: Genetic dissection of down syndrome‑associated alterations in APP/amyloid‑β biology using mouse models

por Tosh, Justin L., Rhymes, Elena R., Mumford, Paige, Whittaker, Heather T., Pulford, Laura J., Noy, Sue J., Cleverley, Karen, Walker, Matthew C., Tybulewicz, Victor L. J., Wykes, Rob C., Fisher, Elizabeth M. C., Wiseman, Frances K.
Publicado 2021

A novel knockout mouse for the small EDRK-rich factor 2 (Serf2) showing developmental and other deficits

por Cleverley, Karen, Lee, Weaverly Colleen, Mumford, Paige, Collins, Toby, Rickman, Matthew, Cunningham, Thomas J., Cleak, James, Mianne, Joffrey, Szoke-Kovacs, Zsombor, Stewart, Michelle, Teboul, Lydia, Maduro, Cheryl, Wells, Sara, Wiseman, Frances K., Fisher, Elizabeth M. C.
Publicado 2021

Downregulated Wnt/β-catenin signalling in the Down syndrome hippocampus

por Granno, Simone, Nixon-Abell, Jonathon, Berwick, Daniel C., Tosh, Justin, Heaton, George, Almudimeegh, Sultan, Nagda, Zenisha, Rain, Jean-Christophe, Zanda, Manuela, Plagnol, Vincent, Tybulewicz, Victor L. J., Cleverley, Karen, Wiseman, Frances K., Fisher, Elizabeth M. C., Harvey, Kirsten
Publicado 2019