PERK Signaling Regulates Extracellular Proteostasis of an Amyloidogenic Protein During Endoplasmic Reticulum Stress

por Romine, Isabelle C., Wiseman, R. Luke
Publicado 2019

Stress-responsive regulation of extracellular proteostasis

por Mesgarzadeh, Jaleh S., Buxbaum, Joel N., Wiseman, R. Luke
Publicado 2022

Cryo-EM structure of hexameric yeast Lon protease (PIM1) highlights the importance of conserved structural elements

por Yang, Jie, Song, Albert S., Wiseman, R. Luke, Lander, Gabriel C.
Publicado 2022

Modulating protein quality control

por Plate, Lars, Paxman, Ryan J, Wiseman, R Luke, Kelly, Jeffery W
Publicado 2016

Quantifying organellar ultrastructure in cryo-electron tomography using a surface morphometrics pipeline

por Barad, Benjamin A., Medina, Michaela, Fuentes, Daniel, Wiseman, R. Luke, Grotjahn, Danielle A.
Publicado 2023

Defining the Functional Targets of Cap‘n’collar Transcription Factors NRF1, NRF2, and NRF3

por Ibrahim, Lara, Mesgarzadeh, Jaleh, Xu, Ian, Powers, Evan T., Wiseman, R. Luke, Bollong, Michael J.
Publicado 2020

Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins

por Paxman, Ryan, Plate, Lars, Blackwood, Erik A, Glembotski, Chris, Powers, Evan T, Wiseman, R Luke, Kelly, Jeffery W
Publicado 2018

Imbalanced unfolded protein response signaling contributes to 1-deoxysphingolipid retinal toxicity

por Rosarda, Jessica D., Giles, Sarah, Harkins-Perry, Sarah, Mills, Elizabeth A., Friedlander, Martin, Wiseman, R. Luke, Eade, Kevin T.
Publicado 2023

Pharmacologic Activation of a Compensatory Integrated Stress Response Kinase Promotes Mitochondrial Remodeling in PERK-deficient Cells

por Perea, Valerie, Baron, Kelsey R., Dolina, Vivian, Aviles, Giovanni, Rosarda, Jessica D., Guo, Xiaoyan, Kampmann, Martin, Wiseman, R. Luke
Publicado 2023

Characterizing the Altered Cellular Proteome Induced by the Stress-Independent Activation of Heat Shock Factor 1

por Ryno, Lisa M., Genereux, Joseph C., Naito, Tadasuke, Morimoto, Richard I., Powers, Evan T., Shoulders, Matthew D., Wiseman, R. Luke
Publicado 2014

The PERK Arm of the Unfolded Protein Response Regulates Mitochondrial Morphology during Acute Endoplasmic Reticulum Stress

por Lebeau, Justine, Saunders, Jaclyn M., Moraes, Vivian W.R., Madhavan, Aparajita, Madrazo, Nicole, Anthony, Mary C., Wiseman, R. Luke
Publicado 2018

Structural basis for distinct operational modes and protease activation in AAA+ protease Lon

por Shin, Mia, Puchades, Cristina, Asmita, Ananya, Puri, Neha, Adjei, Eric, Wiseman, R. Luke, Karzai, A. Wali, Lander, Gabriel C.
Publicado 2020

Structures of the human LONP1 protease reveal regulatory steps involved in protease activation

por Shin, Mia, Watson, Edmond R., Song, Albert S., Mindrebo, Jeffrey T., Novick, Scott J., Griffin, Patrick R., Wiseman, R. Luke, Lander, Gabriel C.
Publicado 2021

Succinylation of a KEAP1 sensor lysine promotes NRF2 activation

por Ibrahim, Lara, Stanton, Caroline, Nutsch, Kayla, Nguyen, Thu, Li-Ma, Chloris, Ko, Yeonjin, Lander, Gabriel C., Wiseman, R. Luke, Bollong, Michael J.
Publicado 2023

PERK signaling promotes mitochondrial elongation by remodeling membrane phosphatidic acid

por Perea, Valerie, Cole, Christian, Lebeau, Justine, Dolina, Vivian, Baron, Kelsey R, Madhavan, Aparajita, Kelly, Jeffery W, Grotjahn, Danielle A, Wiseman, R Luke
Publicado 2023

Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis

por Blackwood, Erik A., Azizi, Khalid, Thuerauf, Donna J., Paxman, Ryan J., Plate, Lars, Kelly, Jeffery W., Wiseman, R. Luke, Glembotski, Christopher C.
Publicado 2019

Metabolically Activated Proteostasis Regulators Protect against Glutamate Toxicity by Activating NRF2

por Rosarda, Jessica D., Baron, Kelsey R., Nutsch, Kayla, Kline, Gabriel M., Stanton, Caroline, Kelly, Jeffery W., Bollong, Michael J., Wiseman, R. Luke
Publicado 2021

ATF6 Activation Reduces Amyloidogenic Transthyretin Secretion through Increased Interactions with Endoplasmic Reticulum Proteostasis Factors

por Mesgarzadeh, Jaleh S., Romine, Isabelle C., Smith-Cohen, Ethan M., Grandjean, Julia M. D., Kelly, Jeffery W., Genereux, Joseph C., Wiseman, R. Luke
Publicado 2022

Quantification of Transthyretin Kinetic Stability in Human Plasma Using Subunit Exchange

por Rappley, Irit, Monteiro, Cecília, Novais, Marta, Baranczak, Aleksandra, Solis, Gregory, Wiseman, R. Luke, Helmke, Stephen, Maurer, Mathew S., Coelho, Teresa, Powers, Evan T., Kelly, Jeffery W.
Publicado 2014

Premature Activation of Immune Transcription Programs in Autoimmune-Predisposed Mouse Embryonic Stem Cells and Blastocysts

por Kirak, Oktay, Ke, Eugene, Yang, Kevin Y., Schwarz, Anna, Plate, Lars, Nham, Amy, Abadejos, Justin R., Valencia, Anna, Wiseman, R. Luke, Lui, Kathy O., Ku, Manching
Publicado 2020