Probing the enzyme kinetics, allosteric modulation and activation of α1- and α2-subunit-containing AMP-activated protein kinase (AMPK) heterotrimeric complexes by pharmacological a...

por Rajamohan, Francis, Reyes, Allan R., Frisbie, Richard K., Hoth, Lise R., Sahasrabudhe, Parag, Magyar, Rachelle, Landro, James A., Withka, Jane M., Caspers, Nicole L., Calabrese, Matthew F., Ward, Jessica, Kurumbail, Ravi G.
Publicado 2016

Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide

por Liu, Shenping, Desharnais, Joel, Sahasrabudhe, Parag V., Jin, Ping, Li, Wei, Oates, Bryan D., Shanker, Suman, Banker, Mary Ellen, Chrunyk, Boris A., Song, Xi, Feng, Xidong, Griffor, Matt, Jimenez, Judith, Chen, Gang, Tumelty, David, Bhat, Abhijit, Bradshaw, Curt W., Woodnutt, Gary, Lappe, Rodney W., Thorarensen, Atli, Qiu, Xiayang, Withka, Jane M., Wood, Lauren D.
Publicado 2016

Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists

por Liu, Shenping, Dakin, Leslie A., Xing, Li, Withka, Jane M., Sahasrabudhe, Parag V., Li, Wei, Banker, Mary Ellen, Balbo, Paul, Shanker, Suman, Chrunyk, Boris A., Guo, Zuojun, Chen, Jinshan M., Young, Jennifer A., Bai, Guoyun, Starr, Jeremy T., Wright, Stephen W., Bussenius, Joerg, Tan, Sheng, Gopalsamy, Ariamala, Lefker, Bruce A., Vincent, Fabien, Jones, Lyn H., Xu, Hua, Hoth, Lise R., Geoghegan, Kieran F., Qiu, Xiayang, Bunnage, Mark E., Thorarensen, Atli
Publicado 2016