From genome-wide association studies to disease mechanisms: celiac disease as a model for autoimmune diseases

por Kumar, Vinod, Wijmenga, Cisca, Withoff, Sebo
Publicado 2012

Celiac disease-on-chip: Modeling a multifactorial disease in vitro

por Moerkens, Renée, Mooiweer, Joram, Withoff, Sebo, Wijmenga, Cisca
Publicado 2019

Small and Long Regulatory RNAs in the Immune System and Immune Diseases

por Stachurska, Anna, Zorro, Maria M., van der Sijde, Marijke R., Withoff, Sebo
Publicado 2014

Intestinal Barrier Function in Gluten-Related Disorders

por Cardoso-Silva, Danielle, Delbue, Deborah, Itzlinger, Alice, Moerkens, Renée, Withoff, Sebo, Branchi, Federica, Schumann, Michael
Publicado 2019

Molecular Biomarkers for Celiac Disease: Past, Present and Future

por Ramírez-Sánchez, Aarón D., Tan, Ineke L., Gonera-de Jong, B.C., Visschedijk, Marijn C., Jonkers, Iris, Withoff, Sebo
Publicado 2020

Long Non-Coding RNAs Involved in Progression of Non-Alcoholic Fatty Liver Disease to Steatohepatitis

por Atanasovska, Biljana, Rensen, Sander S., Marsman, Glenn, Shiri-Sverdlov, Ronit, Withoff, Sebo, Kuipers, Folkert, Wijmenga, Cisca, van de Sluis, Bart, Fu, Jingyuan
Publicado 2021

A Combined mRNA- and miRNA-Sequencing Approach Reveals miRNAs as Potential Regulators of the Small Intestinal Transcriptome in Celiac Disease

por Tan, Ineke Luise, Barisani, Donatella, Panceri, Roberto, Modderman, Rutger, Visschedijk, Marijn, Weersma, Rinse K., Wijmenga, Cisca, Jonkers, Iris, Coutinho de Almeida, Rodrigo, Withoff, Sebo
Publicado 2021

Leukocyte-Released Mediators in Response to Both Bacterial and Fungal Infections Trigger IFN Pathways, Independent of IL-1 and TNF-α, in Endothelial Cells

por Le, Kieu T. T., Chu, Xiaojing, Jaeger, Martin, Plantinga, Josée A., Matzaraki, Vasiliki, Withoff, Sebo, Joosten, Leo A. B., Netea, Mihai G., Wijmenga, Cisca, Li, Yang, Moser, Jill, Kumar, Vinod
Publicado 2019

Tissue alarmins and adaptive cytokine induce dynamic and distinct transcriptional responses in tissue-resident intraepithelial cytotoxic T lymphocytes

por Zorro, Maria Magdalena, Aguirre-Gamboa, Raul, Mayassi, Toufic, Ciszewski, Cezary, Barisani, Donatella, Hu, Shixian, Weersma, Rinse K, Withoff, Sebo, Li, Yang, Wijmenga, Cisca, Jabri, Bana, Jonkers, Iris H
Publicado 2020

Single-Cell RNA Sequencing of Peripheral Blood Mononuclear Cells From Pediatric Coeliac Disease Patients Suggests Potential Pre-Seroconversion Markers

por Ramírez-Sánchez, Aarón D., Chu, Xiaojing, Modderman, Rutger, Kooy-Winkelaar, Yvonne, Koletzko, Sibylle, Korponay-Szabó, Ilma R., Troncone, Riccardo, Wijmenga, Cisca, Mearin, Luisa, Withoff, Sebo, Jonkers, Iris H., Li, Yang
Publicado 2022

Expression profiles of long non-coding RNAs located in autoimmune disease-associated regions reveal immune cell-type specificity

por Hrdlickova, Barbara, Kumar, Vinod, Kanduri, Kartiek, Zhernakova, Daria V, Tripathi, Subhash, Karjalainen, Juha, Lund, Riikka J, Li, Yang, Ullah, Ubaid, Modderman, Rutger, Abdulahad, Wayel, Lähdesmäki, Harri, Franke, Lude, Lahesmaa, Riitta, Wijmenga, Cisca, Withoff, Sebo
Publicado 2014

Gut mucosa dissociation protocols influence cell type proportions and single-cell gene expression levels

por Uniken Venema, Werna T. C., Ramírez-Sánchez, Aarón D., Bigaeva, Emilia, Withoff, Sebo, Jonkers, Iris, McIntyre, Rebecca E., Ghouraba, Mennatallah, Raine, Tim, Weersma, Rinse K., Franke, Lude, Festen, Eleonora A. M., van der Wijst, Monique G. P.
Publicado 2022

Human Disease-Associated Genetic Variation Impacts Large Intergenic Non-Coding RNA Expression

por Kumar, Vinod, Westra, Harm-Jan, Karjalainen, Juha, Zhernakova, Daria V., Esko, Tõnu, Hrdlickova, Barbara, Almeida, Rodrigo, Zhernakova, Alexandra, Reinmaa, Eva, Võsa, Urmo, Hofker, Marten H., Fehrmann, Rudolf S. N., Fu, Jingyuan, Withoff, Sebo, Metspalu, Andres, Franke, Lude, Wijmenga, Cisca
Publicado 2013

Inflammatory Protein Profiles in Plasma of Candidaemia Patients and the Contribution of Host Genetics to Their Variability

por Matzaraki, Vasiliki, Le, Kieu T. T., Jaeger, Martin, Aguirre-Gamboa, Raúl, Johnson, Melissa D., Sanna, Serena, Rosati, Diletta, Franke, Lude, Zhernakova, Alexandra, Fu, Jingyuan, Withoff, Sebo, Jonkers, Iris, Li, Yang, Joosten, Leo A. B., Netea, Mihai G., Wijmenga, Cisca, Kumar, Vinod
Publicado 2021

An integrative genomics approach identifies novel pathways that influence candidaemia susceptibility

por Matzaraki, Vasiliki, Gresnigt, Mark S., Jaeger, Martin, Ricaño-Ponce, Isis, Johnson, Melissa D., Oosting, Marije, Franke, Lude, Withoff, Sebo, Perfect, John R., Joosten, Leo A. B., Kullberg, Bart Jan, van de Veerdonk, Frank L., Jonkers, Iris, Li, Yang, Wijmenga, Cisca, Netea, Mihai G., Kumar, Vinod
Publicado 2017

Integration of multi-omics data and deep phenotyping enables prediction of cytokine responses

por Bakker, Olivier B., Aguirre-Gamboa, Raul, Sanna, Serena, Oosting, Marije, Smeekens, Sanne P., Jaeger, Martin, Zorro, Maria, Võsa, Urmo, Withoff, Sebo, Netea-Maier, Romana T., Koenen, Hans J.P.M., Joosten, Irma, Xavier, Ramnik J., Franke, Lude, Joosten, Leo A.B., Kumar, Vinod, Wijmenga, Cisca, Netea, Mihai G., Li, Yang
Publicado 2018

Systematic Prioritization of Candidate Genes in Disease Loci Identifies TRAFD1 as a Master Regulator of IFNγ Signaling in Celiac Disease

por van der Graaf, Adriaan, Zorro, Maria M., Claringbould, Annique, Võsa, Urmo, Aguirre-Gamboa, Raúl, Li, Chan, Mooiweer, Joram, Ricaño-Ponce, Isis, Borek, Zuzanna, Koning, Frits, Kooy-Winkelaar, Yvonne, Sollid, Ludvig M., Qiao, Shuo-Wang, Kumar, Vinod, Li, Yang, Franke, Lude, Withoff, Sebo, Wijmenga, Cisca, Sanna, Serena, Jonkers, Iris
Publicado 2021

Potential impact of celiac disease genetic risk factors on T cell receptor signaling in gluten-specific CD4+ T cells

por Bakker, Olivier B., Ramírez-Sánchez, Aarón D., Borek, Zuzanna A., de Klein, Niek, Li, Yang, Modderman, Rutger, Kooy-Winkelaar, Yvonne, Johannesen, Marie K., Matarese, Filomena, Martens, Joost H. A., Kumar, Vinod, van Bergen, Jeroen, Qiao, Shuo-Wang, Lundin, Knut E. A., Sollid, Ludvig M., Koning, Frits, Wijmenga, Cisca, Withoff, Sebo, Jonkers, Iris H.
Publicado 2021

Fine mapping of the celiac disease-associated LPP locus reveals a potential functional variant

por Almeida, Rodrigo, Ricaño-Ponce, Isis, Kumar, Vinod, Deelen, Patrick, Szperl, Agata, Trynka, Gosia, Gutierrez-Achury, Javier, Kanterakis, Alexandros, Westra, Harm-Jan, Franke, Lude, Swertz, Morris A., Platteel, Mathieu, Bilbao, Jose Ramon, Barisani, Donatella, Greco, Luigi, Mearin, Luisa, Wolters, Victorien M., Mulder, Chris, Mazzilli, Maria Cristina, Sood, Ajit, Cukrowska, Bozena, Núñez, Concepción, Pratesi, Riccardo, Withoff, Sebo, Wijmenga, Cisca
Publicado 2014

Refined mapping of autoimmune disease associated genetic variants with gene expression suggests an important role for non-coding RNAs

por Ricaño-Ponce, Isis, Zhernakova, Daria V., Deelen, Patrick, Luo, Oscar, Li, Xingwang, Isaacs, Aaron, Karjalainen, Juha, Di Tommaso, Jennifer, Borek, Zuzanna Agnieszka, Zorro, Maria M., Gutierrez-Achury, Javier, Uitterlinden, Andre G., Hofman, Albert, van Meurs, Joyce, Netea, Mihai G., Jonkers, Iris H., Withoff, Sebo, van Duijn, Cornelia M., Li, Yang, Ruan, Yijun, Franke, Lude, Wijmenga, Cisca, Kumar, Vinod
Publicado 2016