HDAC Family Members Intertwined in the Regulation of Autophagy: A Druggable Vulnerability in Aggressive Tumor Entities

por Koeneke, Emily, Witt, Olaf, Oehme, Ina
Publicado 2015

MAPK pathway activation in pilocytic astrocytoma

por Jones, David T. W., Gronych, Jan, Lichter, Peter, Witt, Olaf, Pfister, Stefan M.
Publicado 2011

Natural History of Pediatric Low-Grade Glioma Disease - First Multi-State Model Analysis

por Goebel, Anna-Maria, Gnekow, Astrid K., Kandels, Daniela, Witt, Olaf, Schmidt, Rene, Hernáiz Driever, Pablo
Publicado 2019

Overactivation of the IGF signalling pathway in osteosarcoma: a potential therapeutic target?

por Ameline, Baptiste, Kovac, Michal, Nathrath, Michaela, Barenboim, Maxim, Witt, Olaf, Krieg, Andreas H, Baumhoer, Daniel
Publicado 2020

Beyond germline genetic testing - heterozygous pathogenic variants in PMS2 in two children with Osteosarcoma and Ependymoma

por Kuhlen, Michaela, Golas, Mariola Monika, Schaller, Tina, Stadler, Nicole, Maier, Felicitas, Witt, Olaf, Frühwald, Michael C.
Publicado 2023

LGG-16. NOVEL COMBINATION THERAPIES FOR PEDIATRIC LOW-GRADE GLIOMA AND CHARACTERIZATION OF THE UNDERLYING CELL DEATH MECHANISMS

por Zeiser, Constantia, Rösch, Lisa, Herter, Sonja, Peterziel, Heike, Selt, Florian, Milde, Till, Witt, Olaf, Oehme, Ina
Publicado 2023

The enzyme activity of histone deacetylase 8 is modulated by a redox-switch

por Jänsch, Niklas, Meyners, Christian, Muth, Marius, Kopranovic, Aleksandra, Witt, Olaf, Oehme, Ina, Meyer-Almes, Franz-Josef
Publicado 2018

Experimental in vivo and in vitro treatment with a new histone deacetylase inhibitor belinostat inhibits the growth of pancreatic cancer

por Dovzhanskiy, Dmitriy I, Arnold, Stefanie M, Hackert, Thilo, Oehme, Ina, Witt, Olaf, Felix, Klaus, Giese, Nathalia, Werner, Jens
Publicado 2012

MBRS-19. SYNERGISM OF HDAC AND PARP INHIBITORS IN MYC-DRIVEN GROUP 3 MEDULLOBLASTOMA CELLS

por Vollmer, Johanna, Ecker, Jonas, Hielscher, Thomas, Valinciute, Gintvile, Oppermann, Sina, Peterziel, Heike, Oehme, Ina, Witt, Olaf, Milde, Till
Publicado 2020

DNA methylation-based classifier and gene expression signatures detect BRCAness in osteosarcoma

por Barenboim, Maxim, Kovac, Michal, Ameline, Baptiste, Jones, David T. W., Witt, Olaf, Bielack, Stefan, Burdach, Stefan, Baumhoer, Daniel, Nathrath, Michaela
Publicado 2021

LGG-11. Analysis of neurosurgical complications in pediatric supratentorial midline low-grade glioma – results from the German LGG studies

por Weiß, Sarah, Schulz, Matthias, Kandels, Daniela, Driever, Pablo Hernáiz, Witt, Olaf, Thomale, Ulrich-Wilhelm, Gnekow, Astrid, le Simon, Michè
Publicado 2022

Outcome and prognostic factors of desmoplastic medulloblastoma treated within a multidisciplinary treatment concept

por Rieken, Stefan, Gaiser, Timo, Mohr, Angela, Welzel, Thomas, Witt, Olaf, Kulozik, Andreas E, Wick, Wolfgang, Debus, Jürgen, Combs, Stephanie E
Publicado 2010

NTRK fusions in osteosarcoma are rare and non‐functional events

por Ameline, Baptiste, Saba, Karim H, Kovac, Michal, Magnusson, Linda, Witt, Olaf, Bielack, Stefan, Nathrath, Michaela, Nord, Karolin H, Baumhoer, Daniel
Publicado 2020

LGG-09. SENOLYTIC AGENT NAVITOCLAX TARGETS VINBLASTINE- AND MAPK INHIBITORS-INDUCED SENESCENT TUMOUR CELLS IN PAEDIATRIC LOW GRADE GLIOMAS

por Guiho, Romain, Selt, Florian, Stone, Thomas, Jacques, Thomas, Hargrave, Darren, Gil, Jesús, Witt, Olaf, Milde, Till, Barbera, Juan Pedro Martinez
Publicado 2021

MODL-01. Targeting replication stress in pediatric brain tumors

por Krausert, Sonja, Mack, Norman, Schwalm, Benjamin, Peterziel, Heike, Oehme, Ina, van Tilburg, Cornelis M, Witt, Olaf, Pfister, Stefan M, Kool, Marcel
Publicado 2022

ERBB and P‐glycoprotein inhibitors break resistance in relapsed neuroblastoma models through P‐glycoprotein

por Rösch, Lisa, Herter, Sonja, Najafi, Sara, Ridinger, Johannes, Peterziel, Heike, Cinatl, Jindrich, Jones, David T. W., Michaelis, Martin, Witt, Olaf, Oehme, Ina
Publicado 2022

Systematic interpretation of microarray data using experiment annotations

por Fellenberg, Kurt, Busold, Christian H, Witt, Olaf, Bauer, Andrea, Beckmann, Boris, Hauser, Nicole C, Frohme, Marcus, Winter, Stefan, Dippon, Jürgen, Hoheisel, Jörg D
Publicado 2006

Class I HDAC inhibition reduces DNA damage repair capacity of MYC-amplified medulloblastoma cells

por Vollmer, Johanna, Ecker, Jonas, Hielscher, Thomas, Valinciute, Gintvile, Ridinger, Johannes, Jamaladdin, Nora, Peterziel, Heike, van Tilburg, Cornelis M., Oehme, Ina, Witt, Olaf, Milde, Till
Publicado 2023

Pediatric and Adult High-Grade Glioma Stem Cell Culture Models Are Permissive to Lytic Infection with Parvovirus H-1

por Josupeit, Rafael, Bender, Sebastian, Kern, Sonja, Leuchs, Barbara, Hielscher, Thomas, Herold-Mende, Christel, Schlehofer, Jörg R., Dinsart, Christiane, Witt, Olaf, Rommelaere, Jean, Lacroix, Jeannine
Publicado 2016

The early evolutionary landscape of osteosarcoma provides clues for targeted treatment strategies

por Kovac, Michal, Ameline, Baptiste, Ribi, Sebastian, Kovacova, Monika, Cross, William, Barenboim, Maxim, Witt, Olaf, Bielack, Stefan, Krieg, Andreas, Hartmann, Wolfgang, Nathrath, Michaela, Baumhoer, Daniel
Publicado 2021