Systems-Level Modeling of Cancer-Fibroblast Interaction

por Wadlow, Raymond C., Wittner, Ben S., Finley, S. Aidan, Bergquist, Henry, Upadhyay, Rabi, Finn, Stephen, Loda, Massimo, Mahmood, Umar, Ramaswamy, Sridhar
Publicado 2009

Systematic functional perturbations uncover a prognostic genetic network driving human breast cancer

por Gallenne, Tristan, Ross, Kenneth N., Visser, Nils L., Salony, Desmet, Christophe J., Wittner, Ben S., Wessels, Lodewyk F.A., Ramaswamy, Sridhar, Peeper, Daniel S.
Publicado 2017

Induction of Stable Drug Resistance in Human Breast Cancer Cells Using a Combinatorial Zinc Finger Transcription Factor Library

por Lee, Jeongeun, Hirsh, Andrew S., Wittner, Ben S., Maeder, Morgan L., Singavarapu, Rajasekhar, Lang, Magdalena, Janarthanan, Sailajah, McDermott, Ultan, Yajnik, Vijay, Ramaswamy, Sridhar, Joung, J. Keith, Sgroi, Dennis C.
Publicado 2011

Dynamic Chromatin Modification Sustains Epithelial-Mesenchymal Transition following Inducible Expression of Snail-1

por Javaid, Sarah, Zhang, Jianmin, Anderssen, Endre, Black, Josh C., Wittner, Ben S., Tajima, Ken, Ting, David T., Smolen, Gromoslaw A., Zubrowski, Matthew, Desai, Rushil, Maheswaran, Shyamala, Ramaswamy, Sridhar, Whetstine, Johnathan R., Haber, Daniel A.
Publicado 2013

CK1ε Is Required for Breast Cancers Dependent on β-Catenin Activity

por Kim, So Young, Dunn, Ian F., Firestein, Ron, Gupta, Piyush, Wardwell, Leslie, Repich, Kara, Schinzel, Anna C., Wittner, Ben, Silver, Serena J., Root, David E., Boehm, Jesse S., Ramaswamy, Sridhar, Lander, Eric S., Hahn, William C.
Publicado 2010

A BRCA1 deficient-like signature is enriched in breast cancer brain metastases and predicts DNA damage-induced poly (ADP-ribose) polymerase inhibitor sensitivity

por McMullin, Ryan P, Wittner, Ben S, Yang, Chuanwei, Denton-Schneider, Benjamin R, Hicks, Daniel, Singavarapu, Raj, Moulis, Sharon, Lee, Jeongeun, Akbari, Mohammad R, Narod, Steven A, Aldape, Kenneth D, Steeg, Patricia S, Ramaswamy, Sridhar, Sgroi, Dennis C
Publicado 2014

SETD1A modulates cell cycle progression through a miRNA network that regulates p53 target genes

por Tajima, Ken, Yae, Toshifumi, Javaid, Sarah, Tam, Oliver, Comaills, Valentine, Morris, Robert, Wittner, Ben S., Liu, Mingzhu, Engstrom, Amanda, Takahashi, Fumiyuki, Black, Joshua C., Ramaswamy, Sridhar, Shioda, Toshihiro, Hammell, Molly, Haber, Daniel A., Whetstine, Johnathan R., Maheswaran, Shyamala
Publicado 2015

TGF-β in the microenvironment induces a physiologically occurring immune-suppressive senescent state

por Matsuda, Satoru, Revandkar, Ajinkya, Dubash, Taronish D., Ravi, Arvind, Wittner, Ben S., Lin, Maoxuan, Morris, Robert, Burr, Risa, Guo, Hongshan, Seeger, Karsen, Szabolcs, Annamaria, Che, Dante, Nieman, Linda, Getz, Gad A., Ting, David T., Lawrence, Michael S., Gainor, Justin, Haber, Daniel A., Maheswaran, Shyamala
Publicado 2023

Downregulation of KEAP1 in melanoma promotes resistance to immune checkpoint blockade

por Fox, Douglas B., Ebright, Richard Y., Hong, Xin, Russell, Hunter C., Guo, Hongshan, LaSalle, Thomas J., Wittner, Ben S., Poux, Nicolas, Vuille, Joanna A., Toner, Mehmet, Hacohen, Nir, Boland, Genevieve M., Sen, Debattama R., Sullivan, Ryan J., Maheswaran, Shyamala, Haber, Daniel A.
Publicado 2023

A microfluidic device for label-free, physical capture of circulating tumor cell-clusters

por Sarioglu, A. Fatih, Aceto, Nicola, Kojic, Nikola, Donaldson, Maria C., Zeinali, Mahnaz, Hamza, Bashar, Engstrom, Amanda, Zhu, Huili, Sundaresan, Tilak K., Miyamoto, David T., Luo, Xi, Bardia, Aditya, Wittner, Ben S., Ramaswamy, Sridhar, Shioda, Toshi, Ting, David T., Stott, Shannon L., Kapur, Ravi, Maheswaran, Shyamala, Haber, Daniel A., Toner, Mehmet
Publicado 2015

COX-2 mediates tumor-stromal prolactin signaling to initiate tumorigenesis

por Zheng, Yu, Comaills, Valentine, Burr, Risa, Boulay, Gaylor, Miyamoto, David T., Wittner, Ben S., Emmons, Erin, Sil, Srinjoy, Koulopoulos, Michael W., Broderick, Katherine T., Tai, Eric, Rengarajan, Shruthi, Kulkarni, Anupriya S., Shioda, Toshi, Wu, Chin-Lee, Ramaswamy, Sridhar, Ting, David T., Toner, Mehmet, Rivera, Miguel N., Maheswaran, Shyamala, Haber, Daniel A.
Publicado 2019

HIF1A signaling selectively supports proliferation of breast cancer in the brain

por Ebright, Richard Y., Zachariah, Marcus A., Micalizzi, Douglas S., Wittner, Ben S., Niederhoffer, Kira L., Nieman, Linda T., Chirn, Brian, Wiley, Devon F., Wesley, Benjamin, Shaw, Brian, Nieblas-Bedolla, Edwin, Atlas, Lian, Szabolcs, Annamaria, Iafrate, Anthony J., Toner, Mehmet, Ting, David T., Brastianos, Priscilla K., Haber, Daniel A., Maheswaran, Shyamala
Publicado 2020

Blood-based monitoring identifies acquired and targetable driver HER2 mutations in endocrine-resistant metastatic breast cancer

por Medford, Arielle J., Dubash, Taronish D., Juric, Dejan, Spring, Laura, Niemierko, Andrzej, Vidula, Neelima, Peppercorn, Jeffrey, Isakoff, Steven, Reeves, Brittany A., LiCausi, Joseph A., Wesley, Benjamin, Malvarosa, Giuliana, Yuen, Megan, Wittner, Ben S., Lawrence, Michael S., Iafrate, A. John, Ellisen, Leif, Moy, Beverly, Toner, Mehmet, Maheswaran, Shyamala, Haber, Daniel A., Bardia, Aditya
Publicado 2019

Modeling the novel SERD elacestrant in cultured fulvestrant-refractory HR-positive breast circulating tumor cells

por Dubash, Taronish D., Bardia, Aditya, Chirn, Brian, Reeves, Brittany A., LiCausi, Joseph A., Burr, Risa, Wittner, Ben S., Rai, Sumit, Patel, Hitisha, Bihani, Teeru, Arlt, Heike, Bidard, Francois-Clement, Kaklamani, Virginia G., Aftimos, Philippe, Cortés, Javier, Scartoni, Simona, Fiascarelli, Alessio, Binaschi, Monica, Habboubi, Nassir, Iafrate, A. John, Toner, Mehmet, Haber, Daniel A., Maheswaran, Shyamala
Publicado 2023

DNA hypomethylation silences antitumor immune genes in early prostate cancer and CTCs

por Guo, Hongshan, Vuille, Joanna A., Wittner, Ben S., Lachtara, Emily M., Hou, Yu, Lin, Maoxuan, Zhao, Ting, Raman, Ayush T., Russell, Hunter C., Reeves, Brittany A., Pleskow, Haley M., Wu, Chin-Lee, Gnirke, Andreas, Meissner, Alexander, Efstathiou, Jason A., Lee, Richard J., Toner, Mehmet, Aryee, Martin J., Lawrence, Michael S., Miyamoto, David T., Maheswaran, Shyamala, Haber, Daniel A.
Publicado 2023

Expression of β-globin by cancer cells promotes cell survival during blood-borne dissemination

por Zheng, Yu, Miyamoto, David T., Wittner, Ben S., Sullivan, James P., Aceto, Nicola, Jordan, Nicole Vincent, Yu, Min, Karabacak, Nezihi Murat, Comaills, Valentine, Morris, Robert, Desai, Rushil, Desai, Niyati, Emmons, Erin, Milner, John D., Lee, Richard J., Wu, Chin-Lee, Sequist, Lecia V., Haas, Wilhelm, Ting, David T., Toner, Mehmet, Ramaswamy, Sridhar, Maheswaran, Shyamala, Haber, Daniel A.
Publicado 2017

RNA sequencing of pancreatic circulating tumour cells implicates WNT signaling in metastasis

por Yu, Min, Ting, David T., Stott, Shannon L., Wittner, Ben S., Ozsolak, Fatih, Paul, Suchismita, Ciciliano, Jordan C., Smas, Malgorzata E., Winokur, Daniel, Gilman, Anna J., Ulman, Matthew J., Xega, Kristina, Contino, Gianmarco, Alagesan, Brinda, Brannigan, Brian W., Milos, Patrice M., Ryan, David P, Sequist, Lecia V., Bardeesy, Nabeel, Ramaswamy, Sridhar, Toner, Mehmet, Maheswaran, Shyamala, Haber, Daniel A.
Publicado 2012

HER2 expression identifies dynamic functional states within circulating breast cancer cells

por Jordan, Nicole Vincent, Bardia, Aditya, Wittner, Ben S., Benes, Cyril, Ligorio, Matteo, Zheng, Yu, Yu, Min, Sundaresan, Tilak K., Licausi, Joseph A., Desai, Rushil, O’Keefe, Ryan M., Ebright, Richard Y., Boukhali, Myriam, Sil, Srinjoy, Onozato, Maristela L., Iafrate, Anthony J., Kapur, Ravi, Sgroi, Dennis, Ting, David T., Toner, Mehmet, Ramaswamy, Sridhar, Haas, Wilhelm, Maheswaran, Shyamala, Haber, Daniel A.
Publicado 2016

Molecular signatures of circulating melanoma cells for monitoring early response to immune checkpoint therapy

por Hong, Xin, Sullivan, Ryan J., Kalinich, Mark, Kwan, Tanya Todorova, Giobbie-Hurder, Anita, Pan, Shiwei, LiCausi, Joseph A., Milner, John D., Nieman, Linda T., Wittner, Ben S., Ho, Uyen, Chen, Tianqi, Kapur, Ravi, Lawrence, Donald P., Flaherty, Keith T., Sequist, Lecia V., Ramaswamy, Sridhar, Miyamoto, David T., Lawrence, Michael, Toner, Mehmet, Isselbacher, Kurt J., Maheswaran, Shyamala, Haber, Daniel A.
Publicado 2018

Single-Cell RNA Sequencing Identifies Extracellular Matrix Gene Expression by Pancreatic Circulating Tumor Cells

por Ting, David T., Wittner, Ben S., Ligorio, Matteo, Jordan, Nicole Vincent, Shah, Ajay M., Miyamoto, David T., Aceto, Nicola, Bersani, Francesca, Brannigan, Brian W., Xega, Kristina, Ciciliano, Jordan C., Zhu, Huili, MacKenzie, Olivia C., Trautwein, Julie, Arora, Kshitij S., Shahid, Mohammad, Ellis, Haley L., Qu, Na, Bardeesy, Nabeel, Rivera, Miguel N., Deshpande, Vikram, Ferrone, Cristina R., Kapur, Ravi, Ramaswamy, Sridhar, Shioda, Toshi, Toner, Mehmet, Maheswaran, Shyamala, Haber, Daniel A.
Publicado 2014