Yeast surface display for protein engineering and characterization

por Gai, S Annie, Wittrup, K Dane
Publicado 2007

Combined treatment using adoptive cell therapy, extended pharmacokinetic IL-2, and tumor-specific antibodies leads to cures of established B16F10 tumors and extended in vivo T cell...

por Opel, Cary F, Wittrup, K Dane
Publicado 2013

A Nonpolycationic Fully Proteinaceous Multiagent System for Potent Targeted Delivery of siRNA

por Liu, David V, Yang, Nicole J, Wittrup, K Dane
Publicado 2014

Synergistic Antitumor Activity from Two-Stage Delivery of Targeted Toxins and Endosome-Disrupting Nanoparticles

por Su, Xingfang, Yang, Nicole, Wittrup, K. Dane, Irvine, Darrell J.
Publicado 2013

Nonspecificity in a nonimmune human scFv repertoire

por Kelly, Ryan L., Zhao, Jessie, Le, Doris, Wittrup, K. Dane
Publicado 2017

Engineered gp120 immunogens that elicit VRC01-like antibodies by vaccination

por Mata-Fink, J, Hanson, M, Kriegsman, B, Irvine, D, Wittrup, K
Publicado 2012

Expression of the 180-Kd Ribosome Receptor Induces Membrane Proliferation and Increased Secretory Activity in Yeast

por Becker, Frank, Block-Alper, Laura, Nakamura, Gerald, Harada, Josephine, Wittrup, K. Dane, Meyer, David I.
Publicado 1999

Immunotherapy-induced antibodies to endogenous retroviral envelope glycoprotein confer tumor protection in mice

por Kang, Byong H., Momin, Noor, Moynihan, Kelly D., Silva, Murillo, Li, Yingzhong, Irvine, Darrell J., Wittrup, K. Dane
Publicado 2021

Chaperone proteins as single component reagents to assess antibody nonspecificity

por Kelly, Ryan L., Geoghegan, James C., Feldman, Jared, Jain, Tushar, Kauke, Monique, Le, Doris, Zhao, Jessie, Wittrup, K. Dane
Publicado 2017

Intratumoral nanobody–IL-2 fusions that bind the tumor extracellular matrix suppress solid tumor growth in mice

por Lutz, Emi A, Jailkhani, Noor, Momin, Noor, Huang, Ying, Sheen, Allison, Kang, Byong H, Wittrup, K Dane, Hynes, Richard O
Publicado 2022

Tumor-localized catalases can fail to alter tumor growth and transcriptional profiles in subcutaneous syngeneic mouse tumor models

por Sheen, Allison, Agarwal, Yash, Cheah, Keith M., Cowles, Sarah C., Stinson, Jordan A., Palmeri, Joseph R., Sikes, Hadley D., Wittrup, K. Dane
Publicado 2023

An affinity threshold for maximum efficacy in anti-PD-1 immunotherapy

por Cowles, Sarah C., Sheen, Allison, Santollani, Luciano, Lutz, Emi A., Lax, Brianna M., Palmeri, Joseph R., Freeman, Gordon J., Wittrup, K. Dane
Publicado 2022

Directed evolution of broadly crossreactive chemokine-blocking antibodies efficacious in arthritis

por Angelini, Alessandro, Miyabe, Yoshishige, Newsted, Daniel, Kwan, Byron H., Miyabe, Chie, Kelly, Ryan L., Jamy, Misha N., Luster, Andrew D., Wittrup, K. Dane
Publicado 2018

Combining the Specific Anti-MUC1 Antibody TAB004 and Lip-MSA-IL-2 Limits Pancreatic Cancer Progression in Immune Competent Murine Models of Pancreatic Ductal Adenocarcinoma

por Dréau, Didier, Moore, Laura Jeffords, Wu, Mike, Roy, Lopa Das, Dillion, Lloye, Porter, Travis, Puri, Rahul, Momin, Noor, Wittrup, K. Dane, Mukherjee, Pinku
Publicado 2019

High throughput cross-interaction measures for human IgG1 antibodies correlate with clearance rates in mice

por Kelly, Ryan L, Sun, Tingwan, Jain, Tushar, Caffry, Isabelle, Yu, Yao, Cao, Yuan, Lynaugh, Heather, Brown, Michael, Vásquez, Maximiliano, Wittrup, K Dane, Xu, Yingda
Publicado 2015

An engineered protein antagonist of K-Ras/B-Raf interaction

por Kauke, Monique J., Traxlmayr, Michael W., Parker, Jillian A., Kiefer, Jonathan D., Knihtila, Ryan, McGee, John, Verdine, Greg, Mattos, Carla, Wittrup, K. Dane
Publicado 2017

Strong Enrichment of Aromatic Residues in Binding Sites from a Charge-neutralized Hyperthermostable Sso7d Scaffold Library

por Traxlmayr, Michael W., Kiefer, Jonathan D., Srinivas, Raja R., Lobner, Elisabeth, Tisdale, Alison W., Mehta, Naveen K., Yang, Nicole J., Tidor, Bruce, Wittrup, K. Dane
Publicado 2016

Manipulating the selection forces during affinity maturation to generate cross-reactive HIV antibodies

por Wang, Shenshen, Mata-Fink, Jordi, Kriegsman, Barry, Hanson, Melissa, Irvine, Darrell J., Eisen, Herman N., Burton, Dennis R., Wittrup, K. Dane, Kardar, Mehran, Chakraborty, Arup K.
Publicado 2015

Molecular Magnetic Resonance Imaging of Tumor Response to Therapy

por Shuhendler, Adam J., Ye, Deju, Brewer, Kimberly D., Bazalova-Carter, Magdalena, Lee, Kyung-Hyun, Kempen, Paul, Dane Wittrup, K., Graves, Edward E., Rutt, Brian, Rao, Jianghong
Publicado 2015

Tregs constrain CD8(+) T cell priming required for curative intratumorally anchored anti-4-1BB immunotherapy

por Palmeri, Joseph R., Lax, Brianna M., Peters, Joshua M., Duhamel, Lauren, Stinson, Jordan A., Santollani, Luciano, Lutz, Emi A., Pinney, William, Bryson, Bryan D., Wittrup, K. Dane
Publicado 2023