The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing

por Begolo, Daniela, Vincent, Isabel M., Giordani, Federica, Pöhner, Ina, Witty, Michael J., Rowan, Timothy G., Bengaly, Zakaria, Gillingwater, Kirsten, Freund, Yvonne, Wade, Rebecca C., Barrett, Michael P., Clayton, Christine
Publicado 2018

Fast in vitro methods to determine the speed of action and the stage-specificity of anti-malarials in Plasmodium falciparum

por Le Manach, Claire, Scheurer, Christian, Sax, Sibylle, Schleiferböck, Sarah, Cabrera, Diego Gonzalez, Younis, Yassir, Paquet, Tanya, Street, Leslie, Smith, Peter, Ding, Xavier C, Waterson, David, Witty, Michael J, Leroy, Didier, Chibale, Kelly, Wittlin, Sergio
Publicado 2013

Identification of a 4-fluorobenzyl l-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT)

por Akama, Tsutomu, Zhang, Yong-Kang, Freund, Yvonne R., Berry, Pamela, Lee, Joanne, Easom, Eric E., Jacobs, Robert T., Plattner, Jacob J., Witty, Michael J., Peter, Rosemary, Rowan, Tim G., Gillingwater, Kirsten, Brun, Reto, Nare, Bakela, Mercer, Luke, Xu, Musheng, Wang, Jiangong, Liang, Hao
Publicado 2018

Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs

por Giordani, Federica, Paape, Daniel, Vincent, Isabel M., Pountain, Andrew W., Fernández-Cortés, Fernando, Rico, Eva, Zhang, Ning, Morrison, Liam J., Freund, Yvonne, Witty, Michael J., Peter, Rosemary, Edwards, Darren Y., Wilkes, Jonathan M., van der Hooft, Justin J. J., Regnault, Clément, Read, Kevin D., Horn, David, Field, Mark C., Barrett, Michael P.
Publicado 2020

Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis

por Smith, Alasdair, Wall, Richard J., Patterson, Stephen, Rowan, Tim, Rico Vidal, Eva, Stojanovski, Laste, Huggett, Margaret, Hampton, Shahienaz E., Thomas, Michael G., Corpas Lopez, Victoriano, Gillingwater, Kirsten, Duke, Jeff, Napier, Grant, Peter, Rose, Vitouley, Hervé S., Harrison, Justin R., Milne, Rachel, Jeacock, Laura, Baker, Nicola, Davis, Susan H., Simeons, Frederick, Riley, Jennifer, Horn, David, Brun, Reto, Zuccotto, Fabio, Witty, Michael J, Wyllie, Susan, Read, Kevin D., Gilbert, Ian H.
Publicado 2022