Incorporating family disease history and controlling case–control imbalance for population-based genetic association studies

por Zhuang, Yongwen, Wolford, Brooke N, Nam, Kisung, Bi, Wenjian, Zhou, Wei, Willer, Cristen J, Mukherjee, Bhramar, Lee, Seunggeun
Publicado 2022

Disclosure of clinically actionable genetic variants to thoracic aortic dissection biobank participants

por Beil, Adelyn, Hornsby, Whitney, Uhlmann, Wendy R., Aatre, Rajani, Arscott, Patricia, Wolford, Brooke, Eagle, Kim A., Yang, Bo, McNamara, Jennifer, Willer, Cristen, Roberts, J. Scott
Publicado 2021

Teaching Python for Data Science: Collaborative development of a modular & interactive curriculum

por Duda, Marlena, Sovacool, Kelly L., Farzaneh, Negar, Nguyen, Vy Kim, Haynes, Sarah E., Falk, Hayley, Furman, Katherine L., Walker, Logan A., Diao, Rucheng, Oneka, Morgan, Drotos, Audrey C., Woloshin, Alana, Dotson, Gabrielle A., Kriebel, April, Meng, Lucy, Thiede, Stephanie N., Lapp, Zena, Wolford, Brooke N.
Publicado 2021

Mitochondrial genome-wide association study of migraine – the HUNT Study

por Børte, Sigrid, Zwart, John-Anker, Skogholt, Anne Heidi, Gabrielsen, Maiken Elvestad, Thomas, Laurent F, Fritsche, Lars G, Surakka, Ida, Nielsen, Jonas B, Zhou, Wei, Wolford, Brooke N, Vigeland, Magnus D, Hagen, Knut, Kristoffersen, Espen Saxhaug, Nyholt, Dale R, Chasman, Daniel I, Brumpton, Ben M, Willer, Cristen J, Winsvold, Bendik S
Publicado 2020

Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies

por Zhou, Wei, Nielsen, Jonas B., Fritsche, Lars G., Dey, Rounak, Gabrielsen, Maiken E., Wolford, Brooke N., LeFaive, Jonathon, VandeHaar, Peter, Gagliano, Sarah A., Gifford, Aliya, Bastarache, Lisa A., Wei, Wei-Qi, Denny, Joshua C., Lin, Maoxuan, Hveem, Kristian, Kang, Hyun Min, Abecasis, Goncalo R., Willer, Cristen J., Lee, Seunggeun
Publicado 2018

Multi-ancestry meta-analysis identifies 5 novel loci for ischemic stroke and reveals heterogeneity of effects between sexes and ancestries

por Surakka, Ida, Wu, Kuan-Han, Hornsby, Whitney, Wolford, Brooke N., Shen, Fred, Zhou, Wei, Huffman, Jennifer E., Pandit, Anita, Hu, Yao, Brumpton, Ben, Skogholt, Anne Heidi, Gabrielsen, Maiken E., Walters, Robin G., Hveem, Kristian, Kooperberg, Charles, Zöllner, Sebastian, Wilson, Peter W.F., Sutton, Nadia R., Daly, Mark J., Neale, Benjamin M., Willer, Cristen J.
Publicado 2023

Type 2 diabetes sex-specific effects associated with E167K coding variant in TM6SF2

por Fan, Yanbo, Wolford, Brooke N., Lu, Haocheng, Liang, Wenying, Sun, Jinjian, Zhou, Wei, Rom, Oren, Mahajan, Anubha, Surakka, Ida, Graham, Sarah E., Liu, Zhipeng, Kim, Hyunbae, Ramdas, Shweta, Fritsche, Lars G., Nielsen, Jonas B., Gabrielsen, Maiken Elvestad, Hveem, Kristian, Yang, Dongshan, Song, Jun, Garcia-Barrio, Minerva T., Zhang, Jifeng, Liu, Wanqing, Zhang, Kezhong, Willer, Cristen J., Chen, Y. Eugene
Publicado 2021

MEPE loss-of-function variant associates with decreased bone mineral density and increased fracture risk

por Surakka, Ida, Fritsche, Lars G., Zhou, Wei, Backman, Joshua, Kosmicki, Jack A., Lu, Haocheng, Brumpton, Ben, Nielsen, Jonas B., Gabrielsen, Maiken E., Skogholt, Anne Heidi, Wolford, Brooke, Graham, Sarah E., Chen, Y. Eugene, Lee, Seunggeun, Kang, Hyun Min, Langhammer, Arnulf, Forsmo, Siri, Åsvold, Bjørn O., Styrkarsdottir, Unnur, Holm, Hilma, Gudbjartsson, Daniel, Stefansson, Kari, Baras, Aris, Abecasis, Goncalo R., Hveem, Kristian, Willer, Cristen J.
Publicado 2020

Interactions between genetic variation and cellular environment in skeletal muscle gene expression

por Taylor, D. Leland, Knowles, David A., Scott, Laura J., Ramirez, Andrea H., Casale, Francesco Paolo, Wolford, Brooke N., Guan, Li, Varshney, Arushi, Albanus, Ricardo D’Oliveira, Parker, Stephen C. J., Narisu, Narisu, Chines, Peter S., Erdos, Michael R., Welch, Ryan P., Kinnunen, Leena, Saramies, Jouko, Sundvall, Jouko, Lakka, Timo A., Laakso, Markku, Tuomilehto, Jaakko, Koistinen, Heikki A., Stegle, Oliver, Boehnke, Michael, Birney, Ewan, Collins, Francis S.
Publicado 2018

Global Biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts

por Wang, Ying, Namba, Shinichi, Lopera, Esteban, Kerminen, Sini, Tsuo, Kristin, Läll, Kristi, Kanai, Masahiro, Zhou, Wei, Wu, Kuan-Han, Favé, Marie-Julie, Bhatta, Laxmi, Awadalla, Philip, Brumpton, Ben, Deelen, Patrick, Hveem, Kristian, Lo Faro, Valeria, Mägi, Reedik, Murakami, Yoshinori, Sanna, Serena, Smoller, Jordan W., Uzunovic, Jasmina, Wolford, Brooke N., Willer, Cristen, Gamazon, Eric R., Cox, Nancy J., Surakka, Ida, Okada, Yukinori, Martin, Alicia R., Hirbo, Jibril
Publicado 2023

The HUNT study: A population-based cohort for genetic research

por Brumpton, Ben M., Graham, Sarah, Surakka, Ida, Skogholt, Anne Heidi, Løset, Mari, Fritsche, Lars G., Wolford, Brooke, Zhou, Wei, Nielsen, Jonas Bille, Holmen, Oddgeir L., Gabrielsen, Maiken E., Thomas, Laurent, Bhatta, Laxmi, Rasheed, Humaira, Zhang, He, Kang, Hyun Min, Hornsby, Whitney, Moksnes, Marta Riise, Coward, Eivind, Melbye, Mads, Giskeødegård, Guro F., Fenstad, Jørn, Krokstad, Steinar, Næss, Marit, Langhammer, Arnulf, Boehnke, Michael, Abecasis, Gonçalo R., Åsvold, Bjørn Olav, Hveem, Kristian, Willer, Cristen J.
Publicado 2022

Genome-wide association study of cardiac troponin I in the general population

por Moksnes, Marta R, Røsjø, Helge, Richmond, Anne, Lyngbakken, Magnus N, Graham, Sarah E, Hansen, Ailin Falkmo, Wolford, Brooke N, Gagliano Taliun, Sarah A, LeFaive, Jonathon, Rasheed, Humaira, Thomas, Laurent F, Zhou, Wei, Aung, Nay, Surakka, Ida, Douville, Nicholas J, Campbell, Archie, Porteous, David J, Petersen, Steffen E, Munroe, Patricia B, Welsh, Paul, Sattar, Naveed, Smith, George Davey, Fritsche, Lars G, Nielsen, Jonas B, Åsvold, Bjørn Olav, Hveem, Kristian, Hayward, Caroline, Willer, Cristen J, Brumpton, Ben M, Omland, Torbjørn
Publicado 2021

The genetic regulatory signature of type 2 diabetes in human skeletal muscle

por Scott, Laura J., Erdos, Michael R., Huyghe, Jeroen R., Welch, Ryan P., Beck, Andrew T., Wolford, Brooke N., Chines, Peter S., Didion, John P., Narisu, Narisu, Stringham, Heather M., Taylor, D. Leland, Jackson, Anne U., Vadlamudi, Swarooparani, Bonnycastle, Lori L., Kinnunen, Leena, Saramies, Jouko, Sundvall, Jouko, Albanus, Ricardo D'Oliveira, Kiseleva, Anna, Hensley, John, Crawford, Gregory E., Jiang, Hui, Wen, Xiaoquan, Watanabe, Richard M., Lakka, Timo A., Mohlke, Karen L., Laakso, Markku, Tuomilehto, Jaakko, Koistinen, Heikki A., Boehnke, Michael, Collins, Francis S., Parker, Stephen C. J.
Publicado 2016

GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer

por Zhou, Wei, Brumpton, Ben, Kabil, Omer, Gudmundsson, Julius, Thorleifsson, Gudmar, Weinstock, Josh, Zawistowski, Matthew, Nielsen, Jonas B., Chaker, Layal, Medici, Marco, Teumer, Alexander, Naitza, Silvia, Sanna, Serena, Schultheiss, Ulla T., Cappola, Anne, Karjalainen, Juha, Kurki, Mitja, Oneka, Morgan, Taylor, Peter, Fritsche, Lars G., Graham, Sarah E., Wolford, Brooke N., Overton, William, Rasheed, Humaira, Haug, Eirin B., Gabrielsen, Maiken E., Skogholt, Anne Heidi, Surakka, Ida, Davey Smith, George, Pandit, Anita, Roychowdhury, Tanmoy, Hornsby, Whitney E., Jonasson, Jon G., Senter, Leigha, Liyanarachchi, Sandya, Ringel, Matthew D., Xu, Li, Kiemeney, Lambertus A., He, Huiling, Netea-Maier, Romana T., Mayordomo, Jose I., Plantinga, Theo S., Hrafnkelsson, Jon, Hjartarson, Hannes, Sturgis, Erich M., Palotie, Aarno, Daly, Mark, Citterio, Cintia E., Arvan, Peter, Brummett, Chad M., Boehnke, Michael, de la Chapelle, Albert, Stefansson, Kari, Hveem, Kristian, Willer, Cristen J., Åsvold, Bjørn Olav
Publicado 2020

Genetic Architecture of Abdominal Aortic Aneurysm in the Million Veteran Program

por Klarin, Derek, Verma, Shefali Setia, Judy, Renae, Dikilitas, Ozan, Wolford, Brooke N., Paranjpe, Ishan, Levin, Michael G., Pan, Cuiping, Tcheandjieu, Catherine, Spin, Joshua M., Lynch, Julie, Assimes, Themistocles L., Åldstedt Nyrønning, Linn, Mattsson, Erney, Edwards, Todd L., Denny, Josh, Larson, Eric, Lee, Ming Ta Michael, Carrell, David, Zhang, Yanfei, Jarvik, Gail P., Gharavi, Ali G., Harley, John, Mentch, Frank, Pacheco, Jennifer A., Hakonarson, Hakon, Skogholt, Anne Heidi, Thomas, Laurent, Gabrielsen, Maiken Elvestad, Hveem, Kristian, Nielsen, Jonas Bille, Zhou, Wei, Fritsche, Lars, Huang, Jie, Natarajan, Pradeep, Sun, Yan V., DuVall, Scott L., Rader, Daniel J., Cho, Kelly, Chang, Kyong-Mi, Wilson, Peter W.F., O’Donnell, Christopher J., Kathiresan, Sekar, Scali, Salvatore T., Berceli, Scott A., Willer, Cristen, Jones, Gregory T., Bown, Matthew J., Nadkarni, Girish, Kullo, Iftikhar J., Ritchie, Marylyn, Damrauer, Scott M., Tsao, Philip S.
Publicado 2020

Author Correction: GWAS of thyroid stimulating hormone highlights the pleiotropic effects and inverse association with thyroid cancer

por Zhou, Wei, Brumpton, Ben, Kabil, Omer, Gudmundsson, Julius, Thorleifsson, Gudmar, Weinstock, Josh, Zawistowski, Matthew, Nielsen, Jonas B., Chaker, Layal, Medici, Marco, Teumer, Alexander, Naitza, Silvia, Sanna, Serena, Schultheiss, Ulla T., Cappola, Anne, Karjalainen, Juha, Kurki, Mitja, Oneka, Morgan, Taylor, Peter, Fritsche, Lars G., Graham, Sarah E., Wolford, Brooke N., Overton, William, Rasheed, Humaira, Haug, Eirin B., Gabrielsen, Maiken E., Skogholt, Anne Heidi, Surakka, Ida, Davey Smith, George, Pandit, Anita, Roychowdhury, Tanmoy, Hornsby, Whitney E., Jonasson, Jon G., Senter, Leigha, Liyanarachchi, Sandya, Ringel, Matthew D., Xu, Li, Kiemeney, Lambertus A., He, Huiling, Netea-Maier, Romana T., Mayordomo, Jose I., Plantinga, Theo S., Hrafnkelsson, Jon, Hjartarson, Hannes, Sturgis, Erich M., Palotie, Aarno, Daly, Mark, Citterio, Cintia E., Arvan, Peter, Brummett, Chad M., Boehnke, Michael, de la Chapelle, Albert, Stefansson, Kari, Hveem, Kristian, Willer, Cristen J., Åsvold, Bjørn Olav
Publicado 2021

Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants

por Aragam, Krishna G., Jiang, Tao, Goel, Anuj, Kanoni, Stavroula, Wolford, Brooke N., Atri, Deepak S., Weeks, Elle M., Wang, Minxian, Hindy, George, Zhou, Wei, Grace, Christopher, Roselli, Carolina, Marston, Nicholas A., Kamanu, Frederick K., Surakka, Ida, Venegas, Loreto Muñoz, Sherliker, Paul, Koyama, Satoshi, Ishigaki, Kazuyoshi, Åsvold, Bjørn O., Brown, Michael R., Brumpton, Ben, de Vries, Paul S., Giannakopoulou, Olga, Giardoglou, Panagiota, Gudbjartsson, Daniel F., Güldener, Ulrich, Haider, Syed M. Ijlal, Helgadottir, Anna, Ibrahim, Maysson, Kastrati, Adnan, Kessler, Thorsten, Kyriakou, Theodosios, Konopka, Tomasz, Li, Ling, Ma, Lijiang, Meitinger, Thomas, Mucha, Sören, Munz, Matthias, Murgia, Federico, Nielsen, Jonas B., Nöthen, Markus M., Pang, Shichao, Reinberger, Tobias, Schnitzler, Gavin, Smedley, Damian, Thorleifsson, Gudmar, von Scheidt, Moritz, Ulirsch, Jacob C., Arnar, David O., Burtt, Noël P., Costanzo, Maria C., Flannick, Jason, Ito, Kaoru, Jang, Dong-Keun, Kamatani, Yoichiro, Khera, Amit V., Komuro, Issei, Kullo, Iftikhar J., Lotta, Luca A., Nelson, Christopher P., Roberts, Robert, Thorgeirsson, Gudmundur, Thorsteinsdottir, Unnur, Webb, Thomas R., Baras, Aris, Björkegren, Johan L. M., Boerwinkle, Eric, Dedoussis, George, Holm, Hilma, Hveem, Kristian, Melander, Olle, Morrison, Alanna C., Orho-Melander, Marju, Rallidis, Loukianos S., Ruusalepp, Arno, Sabatine, Marc S., Stefansson, Kari, Zalloua, Pierre, Ellinor, Patrick T., Farrall, Martin, Danesh, John, Ruff, Christian T., Finucane, Hilary K., Hopewell, Jemma C., Clarke, Robert, Gupta, Rajat M., Erdmann, Jeanette, Samani, Nilesh J., Schunkert, Heribert, Watkins, Hugh, Willer, Cristen J., Deloukas, Panos, Kathiresan, Sekar, Butterworth, Adam S.
Publicado 2022

Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target

por Roychowdhury, Tanmoy, Klarin, Derek, Levin, Michael G., Spin, Joshua M., Rhee, Yae Hyun, Deng, Alicia, Headley, Colwyn A., Tsao, Noah L., Gellatly, Corry, Zuber, Verena, Shen, Fred, Hornsby, Whitney E., Laursen, Ina Holst, Verma, Shefali S., Locke, Adam E., Einarsson, Gudmundur, Thorleifsson, Gudmar, Graham, Sarah E., Dikilitas, Ozan, Pattee, Jack W., Judy, Renae L., Pauls-Verges, Ferran, Nielsen, Jonas B., Wolford, Brooke N., Brumpton, Ben M., Dilmé, Jaume, Peypoch, Olga, Juscafresa, Laura Calsina, Edwards, Todd L., Li, Dadong, Banasik, Karina, Brunak, Søren, Jacobsen, Rikke L., Garcia-Barrio, Minerva T., Zhang, Jifeng, Rasmussen, Lars M., Lee, Regent, Handa, Ashok, Wanhainen, Anders, Mani, Kevin, Lindholt, Jes S., Obel, Lasse M., Strauss, Ewa, Oszkinis, Grzegorz, Nelson, Christopher P., Saxby, Katie L., van Herwaarden, Joost A., van der Laan, Sander W., van Setten, Jessica, Camacho, Mercedes, Davis, Frank M., Wasikowski, Rachael, Tsoi, Lam C., Gudjonsson, Johann E., Eliason, Jonathan L., Coleman, Dawn M., Henke, Peter K., Ganesh, Santhi K., Chen, Y. Eugene, Guan, Weihua, Pankow, James S., Pankratz, Nathan, Pedersen, Ole B., Erikstrup, Christian, Tang, Weihong, Hveem, Kristian, Gudbjartsson, Daniel, Gretarsdottir, Solveig, Thorsteinsdottir, Unnur, Holm, Hilma, Stefansson, Kari, Ferreira, Manuel A., Baras, Aris, Kullo, Iftikhar J., Ritchie, Marylyn D., Christensen, Alex H., Iversen, Kasper K., Eldrup, Nikolaj, Sillesen, Henrik, Ostrowski, Sisse R., Bundgaard, Henning, Ullum, Henrik, Burgess, Stephen, Gill, Dipender, Gallagher, Katherine, Sabater-Lleal, Maria, Surakka, Ida, Jones, Gregory T., Bown, Matthew J., Tsao, Philip S., Willer, Cristen J., Damrauer, Scott M.
Publicado 2023

Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease

por Nielsen, Jonas B., Rom, Oren, Surakka, Ida, Graham, Sarah E., Zhou, Wei, Roychowdhury, Tanmoy, Fritsche, Lars G., Gagliano Taliun, Sarah A., Sidore, Carlo, Liu, Yuhao, Gabrielsen, Maiken E., Skogholt, Anne Heidi, Wolford, Brooke, Overton, William, Zhao, Ying, Chen, Jin, Zhang, He, Hornsby, Whitney E., Acheampong, Akua, Grooms, Austen, Schaefer, Amanda, Zajac, Gregory J. M., Villacorta, Luis, Zhang, Jifeng, Brumpton, Ben, Løset, Mari, Rai, Vivek, Lundegaard, Pia R., Olesen, Morten S., Taylor, Kent D., Palmer, Nicholette D., Chen, Yii-Der, Choi, Seung H., Lubitz, Steven A., Ellinor, Patrick T., Barnes, Kathleen C., Daya, Michelle, Rafaels, Nicholas, Weiss, Scott T., Lasky-Su, Jessica, Tracy, Russell P., Vasan, Ramachandran S., Cupples, L. Adrienne, Mathias, Rasika A., Yanek, Lisa R., Becker, Lewis C., Peyser, Patricia A., Bielak, Lawrence F., Smith, Jennifer A., Aslibekyan, Stella, Hidalgo, Bertha A., Arnett, Donna K., Irvin, Marguerite R., Wilson, James G., Musani, Solomon K., Correa, Adolfo, Rich, Stephen S., Guo, Xiuqing, Rotter, Jerome I., Konkle, Barbara A., Johnsen, Jill M., Ashley-Koch, Allison E., Telen, Marilyn J., Sheehan, Vivien A., Blangero, John, Curran, Joanne E., Peralta, Juan M., Montgomery, Courtney, Sheu, Wayne H-H, Chung, Ren-Hua, Schwander, Karen, Nouraie, Seyed M., Gordeuk, Victor R., Zhang, Yingze, Kooperberg, Charles, Reiner, Alexander P., Jackson, Rebecca D., Bleecker, Eugene R., Meyers, Deborah A., Li, Xingnan, Das, Sayantan, Yu, Ketian, LeFaive, Jonathon, Smith, Albert, Blackwell, Tom, Taliun, Daniel, Zollner, Sebastian, Forer, Lukas, Schoenherr, Sebastian, Fuchsberger, Christian, Pandit, Anita, Zawistowski, Matthew, Kheterpal, Sachin, Brummett, Chad M., Natarajan, Pradeep, Schlessinger, David, Lee, Seunggeun, Kang, Hyun Min, Cucca, Francesco, Holmen, Oddgeir L., Åsvold, Bjørn O., Boehnke, Michael, Kathiresan, Sekar, Abecasis, Goncalo R., Chen, Y. Eugene, Willer, Cristen J., Hveem, Kristian
Publicado 2020

Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices

por Natarajan, Pradeep, Pampana, Akhil, Graham, Sarah E., Ruotsalainen, Sanni E., Perry, James A., de Vries, Paul S., Broome, Jai G., Pirruccello, James P., Honigberg, Michael C., Aragam, Krishna, Wolford, Brooke, Brody, Jennifer A., Antonacci-Fulton, Lucinda, Arden, Moscati, Aslibekyan, Stella, Assimes, Themistocles L., Ballantyne, Christie M., Bielak, Lawrence F., Bis, Joshua C., Cade, Brian E., Do, Ron, Doddapaneni, Harsha, Emery, Leslie S., Hung, Yi-Jen, Irvin, Marguerite R., Khan, Alyna T., Lange, Leslie, Lee, Jiwon, Lemaitre, Rozenn N., Martin, Lisa W., Metcalf, Ginger, Montasser, May E., Moon, Jee-Young, Muzny, Donna, O’Connell, Jeffrey R., Palmer, Nicholette D., Peralta, Juan M., Peyser, Patricia A., Stilp, Adrienne M., Tsai, Michael, Wang, Fei Fei, Weeks, Daniel E., Yanek, Lisa R., Wilson, James G., Abecasis, Goncalo, Arnett, Donna K., Becker, Lewis C., Blangero, John, Boerwinkle, Eric, Bowden, Donald W., Chang, Yi-Cheng, Chen, Yii-Der I., Choi, Won Jung, Correa, Adolfo, Curran, Joanne E., Daly, Mark J., Dutcher, Susan K., Ellinor, Patrick T., Fornage, Myriam, Freedman, Barry I., Gabriel, Stacey, Germer, Soren, Gibbs, Richard A., He, Jiang, Hveem, Kristian, Jarvik, Gail P., Kaplan, Robert C., Kardia, Sharon L. R., Kenny, Eimear, Kim, Ryan W., Kooperberg, Charles, Laurie, Cathy C., Lee, Seonwook, Lloyd-Jones, Don M., Loos, Ruth J. F., Lubitz, Steven A., Mathias, Rasika A., Martinez, Karine A. Viaud, McGarvey, Stephen T., Mitchell, Braxton D., Nickerson, Deborah A., North, Kari E., Palotie, Aarno, Park, Cheol Joo, Psaty, Bruce M., Rao, D. C., Redline, Susan, Reiner, Alexander P., Seo, Daekwan, Seo, Jeong-Sun, Smith, Albert V., Tracy, Russell P., Vasan, Ramachandran S., Kathiresan, Sekar, Cupples, L. Adrienne, Rotter, Jerome I., Morrison, Alanna C., Rich, Stephen S., Ripatti, Samuli, Willer, Cristen, Peloso, Gina M.
Publicado 2021