Novel starting points for fragment-based drug design against mycobacterial thioredoxin reductase identified using crystallographic fragment screening

por Füsser, Friederike T., Wollenhaupt, Jan, Weiss, Manfred S., Kümmel, Daniel, Koch, Oliver
Publicado 2023

Synthesis of 2′-Fluoro RNA by Syn5 RNA polymerase

por Zhu, Bin, Hernandez, Alfredo, Tan, Min, Wollenhaupt, Jan, Tabor, Stanley, Richardson, Charles C.
Publicado 2015

Facilitated crystal handling using a simple device for evaporation reduction in microtiter plates

por Barthel, Tatjana, Huschmann, Franziska U., Wallacher, Dirk, Feiler, Christian G., Klebe, Gerhard, Weiss, Manfred S., Wollenhaupt, Jan
Publicado 2021

Large-scale ratcheting in a bacterial DEAH/RHA-type RNA helicase that modulates antibiotics susceptibility

por Grass, Lena M., Wollenhaupt, Jan, Barthel, Tatjana, Parfentev, Iwan, Urlaub, Henning, Loll, Bernhard, Klauck, Eberhard, Antelmann, Haike, Wahl, Markus C.
Publicado 2021

Of problems and opportunities—How to treat and how to not treat crystallographic fragment screening data

por Weiss, Manfred S., Wollenhaupt, Jan, Correy, Galen J., Fraser, James S., Heine, Andreas, Klebe, Gerhard, Krojer, Tobias, Thunissen, Marjolein, Pearce, Nicholas M.
Publicado 2022

FragMAXapp: crystallographic fragment-screening data-analysis and project-management system

por Lima, Gustavo M. A., Jagudin, Elmir, Talibov, Vladimir O., Benz, Laila S., Marullo, Costantino, Barthel, Tatjana, Wollenhaupt, Jan, Weiss, Manfred S., Mueller, Uwe
Publicado 2021

Frag4Lead: growing crystallographic fragment hits by catalog using fragment-guided template docking

por Metz, Alexander, Wollenhaupt, Jan, Glöckner, Steffen, Messini, Niki, Huber, Simon, Barthel, Tatjana, Merabet, Ahmed, Gerber, Hans-Dieter, Heine, Andreas, Klebe, Gerhard, Weiss, Manfred S.
Publicado 2021

The MECP2‐TRD domain interacts with the DNMT3A‐ADD domain at the H3‐tail binding site

por Kunert, Stefan, Linhard, Verena, Weirich, Sara, Choudalakis, Michel, Osswald, Florian, Krämer, Lisa, Köhler, Anja R., Bröhm, Alexander, Wollenhaupt, Jan, Schwalbe, Harald, Jeltsch, Albert
Publicado 2023

A composite double-/single-stranded RNA-binding region in protein Prp3 supports tri-snRNP stability and splicing

por Liu, Sunbin, Mozaffari-Jovin, Sina, Wollenhaupt, Jan, Santos, Karine F, Theuser, Matthias, Dunin-Horkawicz, Stanislaw, Fabrizio, Patrizia, Bujnicki, Janusz M, Lührmann, Reinhard, Wahl, Markus C
Publicado 2015

The large N-terminal region of the Brr2 RNA helicase guides productive spliceosome activation

por Absmeier, Eva, Wollenhaupt, Jan, Mozaffari-Jovin, Sina, Becke, Christian, Lee, Chung-Tien, Preussner, Marco, Heyd, Florian, Urlaub, Henning, Lührmann, Reinhard, Santos, Karine F., Wahl, Markus C.
Publicado 2015

Redox-Sensing Under Hypochlorite Stress and Infection Conditions by the Rrf2-Family Repressor HypR in Staphylococcus aureus

por Loi, Vu Van, Busche, Tobias, Tedin, Karsten, Bernhardt, Jörg, Wollenhaupt, Jan, Huyen, Nguyen Thi Thu, Weise, Christoph, Kalinowski, Jörn, Wahl, Markus C., Fulde, Marcus, Antelmann, Haike
Publicado 2018

Binding Adaptation of GS-441524 Diversifies Macro Domains and Downregulates SARS-CoV-2 de-MARylation Capacity

por Tsika, Aikaterini C., Gallo, Angelo, Fourkiotis, Nikolaos K., Argyriou, Aikaterini I., Sreeramulu, Sridhar, Löhr, Frank, Rogov, Vladimir V., Richter, Christian, Linhard, Verena, Gande, Santosh L., Altincekic, Nadide, Krishnathas, Robin, Elamri, Isam, Schwalbe, Harald, Wollenhaupt, Jan, Weiss, Manfred S., Spyroulias, Georgios A.
Publicado 2022

X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease

por Günther, Sebastian, Reinke, Patrick Y. A., Fernández-García, Yaiza, Lieske, Julia, Lane, Thomas J., Ginn, Helen M., Koua, Faisal H. M., Ehrt, Christiane, Ewert, Wiebke, Oberthuer, Dominik, Yefanov, Oleksandr, Meier, Susanne, Lorenzen, Kristina, Krichel, Boris, Kopicki, Janine-Denise, Gelisio, Luca, Brehm, Wolfgang, Dunkel, Ilona, Seychell, Brandon, Gieseler, Henry, Norton-Baker, Brenna, Escudero-Pérez, Beatriz, Domaracky, Martin, Saouane, Sofiane, Tolstikova, Alexandra, White, Thomas A., Hänle, Anna, Groessler, Michael, Fleckenstein, Holger, Trost, Fabian, Galchenkova, Marina, Gevorkov, Yaroslav, Li, Chufeng, Awel, Salah, Peck, Ariana, Barthelmess, Miriam, Schlünzen, Frank, Lourdu Xavier, P., Werner, Nadine, Andaleeb, Hina, Ullah, Najeeb, Falke, Sven, Srinivasan, Vasundara, França, Bruno Alves, Schwinzer, Martin, Brognaro, Hévila, Rogers, Cromarte, Melo, Diogo, Zaitseva-Doyle, Joanna J., Knoska, Juraj, Peña-Murillo, Gisel E., Mashhour, Aida Rahmani, Hennicke, Vincent, Fischer, Pontus, Hakanpää, Johanna, Meyer, Jan, Gribbon, Philip, Ellinger, Bernhard, Kuzikov, Maria, Wolf, Markus, Beccari, Andrea R., Bourenkov, Gleb, von Stetten, David, Pompidor, Guillaume, Bento, Isabel, Panneerselvam, Saravanan, Karpics, Ivars, Schneider, Thomas R., Garcia-Alai, Maria Marta, Niebling, Stephan, Günther, Christian, Schmidt, Christina, Schubert, Robin, Han, Huijong, Boger, Juliane, Monteiro, Diana C. F., Zhang, Linlin, Sun, Xinyuanyuan, Pletzer-Zelgert, Jonathan, Wollenhaupt, Jan, Feiler, Christian G., Weiss, Manfred S., Schulz, Eike-Christian, Mehrabi, Pedram, Karničar, Katarina, Usenik, Aleksandra, Loboda, Jure, Tidow, Henning, Chari, Ashwin, Hilgenfeld, Rolf, Uetrecht, Charlotte, Cox, Russell, Zaliani, Andrea, Beck, Tobias, Rarey, Matthias, Günther, Stephan, Turk, Dusan, Hinrichs, Winfried, Chapman, Henry N., Pearson, Arwen R., Betzel, Christian, Meents, Alke
Publicado 2021