Facilitating Machine Learning‐Guided Protein Engineering with Smart Library Design and Massively Parallel Assays

por Chu, Hoi Yee, Wong, Alan S. L.
Publicado 2021

Combinatorial genetics methods for discovering high-order regulatory combinations and engineering genetic drivers for neural differentiation

por Thean, Dawn G. L., Wong, Alan S. L.
Publicado 2021

Extensible combinatorial CRISPR screening in mammalian cells

por Zhou, Peng, Wan, Yuk Kei, Chan, Becky K.C., Choi, Gigi C.G., Wong, Alan S.L.
Publicado 2021

High-throughput 5′ UTR engineering for enhanced protein production in non-viral gene therapies

por Cao, Jicong, Novoa, Eva Maria, Zhang, Zhizhuo, Chen, William C. W., Liu, Dianbo, Choi, Gigi C. G., Wong, Alan S. L., Wehrspaun, Claudia, Kellis, Manolis, Lu, Timothy K.
Publicado 2021

Machine learning-coupled combinatorial mutagenesis enables resource-efficient engineering of CRISPR-Cas9 genome editor activities

por Thean, Dawn G. L., Chu, Hoi Yee, Fong, John H. C., Chan, Becky K. C., Zhou, Peng, Kwok, Cynthia C. S., Chan, Yee Man, Mak, Silvia Y. L., Choi, Gigi C. G., Ho, Joshua W. K., Zheng, Zongli, Wong, Alan S. L.
Publicado 2022

High-fidelity KKH variant of Staphylococcus aureus Cas9 nucleases with improved base mismatch discrimination

por Yuen, Chaya T L, Thean, Dawn G L, Chan, Becky K C, Zhou, Peng, Kwok, Cynthia C S, Chu, Hoi Yee, Cheung, Maggie S H, Wang, Bei, Chan, Yee Man, Mak, Silvia Y L, Leung, Anskar Y, Choi, Gigi C G, Zheng, Zongli, Wong, Alan S L
Publicado 2022

Cycloguanil and Analogues Potently Target DHFR in Cancer Cells to Elicit Anti-Cancer Activity

por Brown, Jennifer I., Wang, Peng, Wong, Alan Y. L., Petrova, Boryana, Persaud, Rosanne, Soukhtehzari, Sepideh, Lopez McDonald, Melanie, Hanke, Danielle, Christensen, Josephine, Iliev, Petar, Wang, Weiyuan, Everton, Daniel K., Williams, Karla C., Frank, David A., Kanarek, Naama, Page, Brent D. G.
Publicado 2023

Reversal of viral and epigenetic HLA class I repression in Merkel cell carcinoma

por Lee, Patrick C., Klaeger, Susan, Le, Phuong M., Korthauer, Keegan, Cheng, Jingwei, Ananthapadmanabhan, Varsha, Frost, Thomas C., Stevens, Jonathan D., Wong, Alan Y.L., Iorgulescu, J. Bryan, Tarren, Anna Y., Chea, Vipheaviny A., Carulli, Isabel P., Lemvigh, Camilla K., Pedersen, Christina B., Gartin, Ashley K., Sarkizova, Siranush, Wright, Kyle T., Li, Letitia W., Nomburg, Jason, Li, Shuqiang, Huang, Teddy, Liu, Xiaoxi, Pomerance, Lucas, Doherty, Laura M., Apffel, Annie M., Wallace, Luke J., Rachimi, Suzanna, Felt, Kristen D., Wolff, Jacquelyn O., Witten, Elizabeth, Zhang, Wandi, Neuberg, Donna, Lane, William J., Zhang, Guanglan, Olsen, Lars R., Thakuria, Manisha, Rodig, Scott J., Clauser, Karl R., Starrett, Gabriel J., Doench, John G., Buhrlage, Sara J., Carr, Steven A., DeCaprio, James A., Wu, Catherine J., Keskin, Derin B.
Publicado 2022