Association of mutation signature effectuating processes with mutation hotspots in driver genes and non-coding regions

por Wong, John K. L., Aichmüller, Christian, Schulze, Markus, Hlevnjak, Mario, Elgaafary, Shaymaa, Lichter, Peter, Zapatka, Marc
Publicado 2022

scSNPdemux: a sensitive demultiplexing pipeline using single nucleotide polymorphisms for improved pooled single-cell RNA sequencing analysis

por Wong, John K. L., Jassowicz, Lena, Herold-Mende, Christel, Seiffert, Martina, Mallm, Jan-Philipp, Lichter, Peter, Zapatka, Marc
Publicado 2023

Evidence for a pre-malignant cell line in a skin biopsy from a patient with Nijmegen breakage syndrome

por Habib, Raneem, Neitzel, Heidemarie, Ernst, Aurelie, Wong, John K. L., Goryluk-Kozakiewicz, Bozenna, Gerlach, Antje, Demuth, Ilja, Sperling, Karl, Chrzanowska, Krystyna
Publicado 2018

Rare variants and de novo variants in mesial temporal lobe epilepsy with hippocampal sclerosis

por Wong, John K.L., Gui, Hongsheng, Kwok, Maxwell, Ng, Ping Wing, Lui, Colin H.T., Baum, Larry, Sham, Pak Chung, Kwan, Patrick, Cherny, Stacey S.
Publicado 2018

Cancer gene mutations in congenital pulmonary airway malformation patients

por Hsu, Jacob Shujui, Zhang, Ruizhong, Yeung, Fanny, Tang, Clara S.M., Wong, John K.L., So, Man-Ting, Xia, Huimin, Sham, Pak, Tam, Paul K., Li, Miaoxin, Wong, Kenneth K.Y., Garcia-Barcelo, Maria-Mercè
Publicado 2019

Genetic study of congenital bile-duct dilatation identifies de novo and inherited variants in functionally related genes

por Wong, John K. L., Campbell, Desmond, Ngo, Ngoc Diem, Yeung, Fanny, Cheng, Guo, Tang, Clara S. M., Chung, Patrick H. Y., Tran, Ngoc Son, So, Man-ting, Cherny, Stacey S., Sham, Pak C., Tam, Paul K., Garcia-Barcelo, Maria-Mercè
Publicado 2016

Carbon ion radiotherapy eradicates medulloblastomas with chromothripsis in an orthotopic Li-Fraumeni patient-derived mouse model

por Simovic, Milena, Bolkestein, Michiel, Moustafa, Mahmoud, Wong, John K L, Körber, Verena, Benedetto, Sarah, Khalid, Umar, Schreiber, Hannah Sophia, Jugold, Manfred, Korshunov, Andrey, Hübschmann, Daniel, Mack, Norman, Brons, Stephan, Wei, Pei-Chi, Breckwoldt, Michael O, Heiland, Sabine, Bendszus, Martin, Debus, Jürgen, Höfer, Thomas, Zapatka, Marc, Kool, Marcel, Pfister, Stefan M, Abdollahi, Amir, Ernst, Aurélie
Publicado 2021

Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors

por Ratnaparkhe, Manasi, Wong, John K. L., Wei, Pei-Chi, Hlevnjak, Mario, Kolb, Thorsten, Simovic, Milena, Haag, Daniel, Paul, Yashna, Devens, Frauke, Northcott, Paul, Jones, David T. W., Kool, Marcel, Jauch, Anna, Pastorczak, Agata, Mlynarski, Wojciech, Korshunov, Andrey, Kumar, Rajiv, Downing, Susanna M., Pfister, Stefan M., Zapatka, Marc, McKinnon, Peter J., Alt, Frederick W., Lichter, Peter, Ernst, Aurélie
Publicado 2018

The landscape of chromothripsis across adult cancer types

por Voronina, Natalia, Wong, John K. L., Hübschmann, Daniel, Hlevnjak, Mario, Uhrig, Sebastian, Heilig, Christoph E., Horak, Peter, Kreutzfeldt, Simon, Mock, Andreas, Stenzinger, Albrecht, Hutter, Barbara, Fröhlich, Martina, Brors, Benedikt, Jahn, Arne, Klink, Barbara, Gieldon, Laura, Sieverling, Lina, Feuerbach, Lars, Chudasama, Priya, Beck, Katja, Kroiss, Matthias, Heining, Christoph, Möhrmann, Lino, Fischer, Andrea, Schröck, Evelin, Glimm, Hanno, Zapatka, Marc, Lichter, Peter, Fröhling, Stefan, Ernst, Aurélie
Publicado 2020