Human Huntington’s disease pluripotent stem cell-derived microglia develop normally but are abnormally hyper-reactive and release elevated levels of reactive oxygen species

por O’Regan, Grace C., Farag, Sahar H., Casey, Caroline S., Wood-Kaczmar, Alison, Pocock, Jennifer M., Tabrizi, Sarah J., Andre, Ralph
Publicado 2021

FAN1 modifies Huntington’s disease progression by stabilizing the expanded HTT CAG repeat

por Goold, Robert, Flower, Michael, Moss, Davina Hensman, Medway, Chris, Wood-Kaczmar, Alison, Andre, Ralph, Farshim, Pamela, Bates, Gill P, Holmans, Peter, Jones, Lesley, Tabrizi, Sarah J
Publicado 2019

Mislocalization of Nucleocytoplasmic Transport Proteins in Human Huntington’s Disease PSC-Derived Striatal Neurons

por Lange, Jenny, Wood-Kaczmar, Alison, Ali, Aneesa, Farag, Sahar, Ghosh, Rhia, Parker, Jennifer, Casey, Caroline, Uno, Yumiko, Kunugi, Akiyoshi, Ferretti, Patrizia, Andre, Ralph, Tabrizi, Sarah J.
Publicado 2021

PINK1-Associated Parkinson's Disease Is Caused by Neuronal Vulnerability to Calcium-Induced Cell Death

por Gandhi, Sonia, Wood-Kaczmar, Alison, Yao, Zhi, Plun-Favreau, Helene, Deas, Emma, Klupsch, Kristina, Downward, Julian, Latchman, David S., Tabrizi, Sarah J., Wood, Nicholas W., Duchen, Michael R., Abramov, Andrey Y.
Publicado 2009

Expression of mutant exon 1 huntingtin fragments in human neural stem cells and neurons causes inclusion formation and mitochondrial dysfunction

por Ghosh, Rhia, Wood‐Kaczmar, Alison, Dobson, Lucianne, Smith, Edward J., Sirinathsinghji, Eva C., Kriston‐Vizi, Janos, Hargreaves, Iain P., Heaton, Robert, Herrmann, Frank, Abramov, Andrey Y., Lam, Amanda J., Heales, Simon J., Ketteler, Robin, Bates, Gillian P., Andre, Ralph, Tabrizi, Sarah J.
Publicado 2020

PINK1 Is Necessary for Long Term Survival and Mitochondrial Function in Human Dopaminergic Neurons

por Wood-Kaczmar, Alison, Gandhi, Sonia, Yao, Zhi, Abramov, Andrey S. Y., Miljan, Erik A., Keen, Gregory, Stanyer, Lee, Hargreaves, Iain, Klupsch, Kristina, Deas, Emma, Downward, Julian, Mansfield, Louise, Jat, Parmjit, Taylor, Joanne, Heales, Simon, Duchen, Michael R., Latchman, David, Tabrizi, Sarah J., Wood, Nicholas W.
Publicado 2008

Correction: PINK1 Is Necessary for Long Term Survival and Mitochondrial Function in Human Dopaminergic Neurons

por Wood-Kaczmar, Alison, Gandhi, Sonia, Yao, Zhi, Abramov, Andrey Y., Miljan, Erik A., Keen, Gregory, Stanyer, Lee, Hargreaves, Iain, Klupsch, Kristina, Deas, Emma, Downward, Julian, Mansfield, Louise, Jat, Parmjit, Taylor, Joanne, Heales, Simon, Duchen, Michael R., Latchman, David, Tabrizi, Sarah J., Wood, Nicholas W.
Publicado 2008

Correction: PINK1 Is Necessary for Long Term Survival and Mitochondrial Function in Human Dopaminergic Neurons

por Wood-Kaczmar, Alison, Gandhi, Sonia, Yao, Zhi, Abramov, Andrey Y., Miljan, Erik A., Keen, Gregory, Stanyer, Lee, Hargreaves, Iain, Klupsch, Kristina, Deas, Emma, Downward, Julian, Mansfield, Louise, Jat, Parmjit, Taylor, Joanne, Heales, Simon, Duchen, Michael R., Latchman, David, Tabrizi, Sarah J., Wood, Nicholas W.
Publicado 2008