Kinase and channel activity of TRPM6 are co-ordinated by a dimerization motif and pocket interaction

por vanderWijst, Jenny, Blanchard, Maxime G., Woodroof, Helen I., Macartney, Thomas J., Gourlay, Robert, Hoenderop, Joost G., Bindels, René J., Alessi, Dario R.
Publicado 2014

Structure of PINK1 and mechanisms of Parkinson's disease-associated mutations

por Kumar, Atul, Tamjar, Jevgenia, Waddell, Andrew D, Woodroof, Helen I, Raimi, Olawale G, Shaw, Andrew M, Peggie, Mark, Muqit, Miratul MK, van Aalten, Daan MF
Publicado 2017

Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity

por Kazlauskaite, Agne, Kelly, Van, Johnson, Clare, Baillie, Carla, Hastie, C. James, Peggie, Mark, Macartney, Thomas, Woodroof, Helen I., Alessi, Dario R., Pedrioli, Patrick G. A., Muqit, Miratul M. K.
Publicado 2014

Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations

por Woodroof, Helen I., Pogson, Joe H., Begley, Mike, Cantley, Lewis C., Deak, Maria, Campbell, David G., van Aalten, Daan M. F., Whitworth, Alexander J., Alessi, Dario R., Muqit, Miratul M. K.
Publicado 2011

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

por Kondapalli, Chandana, Kazlauskaite, Agne, Zhang, Ning, Woodroof, Helen I., Campbell, David G., Gourlay, Robert, Burchell, Lynn, Walden, Helen, Macartney, Thomas J., Deak, Maria, Knebel, Axel, Alessi, Dario R., Muqit, Miratul M. K.
Publicado 2012

Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1

por Lai, Yu‐Chiang, Kondapalli, Chandana, Lehneck, Ronny, Procter, James B, Dill, Brian D, Woodroof, Helen I, Gourlay, Robert, Peggie, Mark, Macartney, Thomas J, Corti, Olga, Corvol, Jean‐Christophe, Campbell, David G, Itzen, Aymelt, Trost, Matthias, Muqit, Miratul MK
Publicado 2015

TigarB causes mitochondrial dysfunction and neuronal loss in PINK1 deficiency

por Flinn, Laura J., Keatinge, Marcus, Bretaud, Sandrine, Mortiboys, Heather, Matsui, Hideaki, De Felice, Elena, Woodroof, Helen I., Brown, Lucy, McTighe, Aimee, Soellner, Rosemarie, Allen, Claire E., Heath, Paul R., Milo, Marta, Muqit, Miratul M. K., Reichert, Andreas S., Köster, Reinhard W., Ingham, Philip W., Bandmann, Oliver
Publicado 2014