Therapeutic Strategies to Reduce the Toxicity of Misfolded Protein Oligomers

por Kreiser, Ryan P., Wright, Aidan K., Block, Natalie R., Hollows, Jared E., Nguyen, Lam T., LeForte, Kathleen, Mannini, Benedetta, Vendruscolo, Michele, Limbocker, Ryan
Publicado 2020

Rationally Designed Antibodies as Research Tools to Study the Structure–Toxicity Relationship of Amyloid-β Oligomers

por Limbocker, Ryan, Mannini, Benedetta, Cataldi, Rodrigo, Chhangur, Shianne, Wright, Aidan K., Kreiser, Ryan P., Albright, J. Alex, Chia, Sean, Habchi, Johnny, Sormanni, Pietro, Kumita, Janet R., Ruggeri, Francesco S., Dobson, Christopher M., Chiti, Fabrizio, Aprile, Francesco A., Vendruscolo, Michele
Publicado 2020

Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism

por Limbocker, Ryan, Mannini, Benedetta, Ruggeri, Francesco S., Cascella, Roberta, Xu, Catherine K., Perni, Michele, Chia, Sean, Chen, Serene W., Habchi, Johnny, Bigi, Alessandra, Kreiser, Ryan P., Wright, Aidan K., Albright, J. Alex, Kartanas, Tadas, Kumita, Janet R., Cremades, Nunilo, Zasloff, Michael, Cecchi, Cristina, Knowles, Tuomas P. J., Chiti, Fabrizio, Vendruscolo, Michele, Dobson, Christopher M.
Publicado 2020

A Brain-Permeable Aminosterol Regulates Cell Membranes to Mitigate the Toxicity of Diverse Pore-Forming Agents

por Kreiser, Ryan P., Wright, Aidan K., Sasser, Liam R., Rinauro, Dillon J., Gabriel, Justus M., Hsu, Claire M., Hurtado, Jorge A., McKenzie, Tristan L., Errico, Silvia, Albright, J. Alex, Richardson, Lance, Jaffett, Victor A., Riegner, Dawn E., Nguyen, Lam T., LeForte, Kathleen, Zasloff, Michael, Hollows, Jared E., Chiti, Fabrizio, Vendruscolo, Michele, Limbocker, Ryan
Publicado 2022

Squalamine and Its Derivatives Modulate the Aggregation of Amyloid-β and α-Synuclein and Suppress the Toxicity of Their Oligomers

por Limbocker, Ryan, Staats, Roxine, Chia, Sean, Ruggeri, Francesco S., Mannini, Benedetta, Xu, Catherine K., Perni, Michele, Cascella, Roberta, Bigi, Alessandra, Sasser, Liam R., Block, Natalie R., Wright, Aidan K., Kreiser, Ryan P., Custy, Edward T., Meisl, Georg, Errico, Silvia, Habchi, Johnny, Flagmeier, Patrick, Kartanas, Tadas, Hollows, Jared E., Nguyen, Lam T., LeForte, Kathleen, Barbut, Denise, Kumita, Janet R., Cecchi, Cristina, Zasloff, Michael, Knowles, Tuomas P. J., Dobson, Christopher M., Chiti, Fabrizio, Vendruscolo, Michele
Publicado 2021