AAV vector production: Troublesome host innate responses in another setting

por Wright, J. Fraser
Publicado 2023

Product-Related Impurities in Clinical-Grade Recombinant AAV Vectors: Characterization and Risk Assessment

por Wright, J. Fraser
Publicado 2014

AAV vector production: Troublesome host innate responses in another setting

por Wright, J. Fraser
Publicado 2023

Towards routine manufacturing of gene therapy drugs

por Merten, Otto-Wilhelm, Wright, J Fraser
Publicado 2016

Challenges Posed by Immune Responses to AAV Vectors: Addressing Root Causes

por Hamilton, Bradley A., Wright, J. Fraser
Publicado 2021

The intersection of vector biology, gene therapy, and hemophilia

por Lisowski, Leszek, Staber, Janice M., Wright, J. Fraser, Valentino, Leonard A.
Publicado 2021

Timing of Intensive Immunosuppression Impacts Risk of Transgene Antibodies after AAV Gene Therapy in Nonhuman Primates

por Samelson-Jones, Benjamin J., Finn, Jonathan D., Favaro, Patricia, Wright, J. Fraser, Arruda, Valder R.
Publicado 2020

Bioengineered coagulation factor VIII enables long-term correction of murine hemophilia A following liver-directed adeno-associated viral vector delivery

por Brown, Harrison C, Wright, J Fraser, Zhou, Shangzhen, Lytle, Allison M, Shields, Jordan E, Spencer, H Trent, Doering, Christopher B
Publicado 2014

Preclinical Potency and Biodistribution Studies of an AAV 5 Vector Expressing Human Interferon-β (ART-I02) for Local Treatment of Patients with Rheumatoid Arthritis

por Aalbers, Caroline J., Bevaart, Lisette, Loiler, Scott, de Cortie, Karin, Wright, J. Fraser, Mingozzi, Federico, Tak, Paul P., Vervoordeldonk, Margriet J.
Publicado 2015

Effects of FVIII immunity on hepatocyte and hematopoietic stem cell–directed gene therapy of murine hemophilia A

por Lytle, Allison M, Brown, Harrison C, Paik, Na Yoon, Knight, Kristopher A, Wright, J Fraser, Spencer, H Trent, Doering, Christopher B
Publicado 2016

Pharmacological Modulation of Humoral Immunity in a Nonhuman Primate Model of AAV Gene Transfer for Hemophilia B

por Mingozzi, Federico, Chen, Yifeng, Murphy, Samuel L, Edmonson, Shyrie C, Tai, Alex, Price, Sandra D, Metzger, Mark E, Zhou, Shangzhen, Wright, J Fraser, Donahue, Robert E, Dunbar, Cynthia E, High, Katherine A
Publicado 2012

Safety and tolerability of MRI-guided infusion of AAV2-hAADC into the mid-brain of nonhuman primate

por Sebastian, Waldy San, Kells, Adrian P, Bringas, John, Samaranch, Lluis, Hadaczek, Piotr, Ciesielska, Agnieszka, Macayan, Michael J, Pivirotto, Phillip J, Forsayeth, John, Osborne, Sheryl, Wright, J Fraser, Green, Foad, Heller, Gregory, Bankiewicz, Krystof S
Publicado 2014

Safety of AAV Factor IX Peripheral Transvenular Gene Delivery to Muscle in Hemophilia B Dogs

por Haurigot, Virginia, Mingozzi, Federico, Buchlis, George, Hui, Daniel J, Chen, Yifeng, Basner-Tschakarjan, Etiena, Arruda, Valder R, Radu, Antoneta, Franck, Helen G, Wright, J Fraser, Zhou, Shangzhen, Stedman, Hansell H, Bellinger, Dwight A, Nichols, Timothy C, High, Katherine A
Publicado 2010

Adeno-associated virus vectored immunoprophylaxis to prevent HIV in healthy adults: a phase 1 randomised controlled trial

por Priddy, Frances H, Lewis, David J M, Gelderblom, Huub C, Hassanin, Hana, Streatfield, Claire, LaBranche, Celia, Hare, Jonathan, Cox, Josephine H, Dally, Len, Bendel, Daryl, Montefiori, David, Sayeed, Eddy, Ackland, Jim, Gilmour, Jill, Schnepp, Bruce C, Wright, J Fraser, Johnson, Philip
Publicado 2019

Safe, Long-term Hepatic Expression of Anti-HCV shRNA in a Nonhuman Primate Model

por Suhy, David A, Kao, Shih-Chu, Mao, Tin, Whiteley, Laurence, Denise, Hubert, Souberbielle, Bernard, Burdick, Andrew D, Hayes, Kyle, Wright, J Fraser, Lavender, Helen, Roelvink, Peter, Kolykhalov, Alexander, Brady, Kevin, Moschos, Sterghios A, Hauck, Bernd, Zelenaia, Olga, Zhou, Shangzhen, Scribner, Curt, High, Katherine A, Renison, Sara H, Corbau, Romu
Publicado 2012

Gene Therapy for Leber's Congenital Amaurosis is Safe and Effective Through 1.5 Years After Vector Administration

por Simonelli, Francesca, Maguire, Albert M, Testa, Francesco, Pierce, Eric A, Mingozzi, Federico, Bennicelli, Jeannette L, Rossi, Settimio, Marshall, Kathleen, Banfi, Sandro, Surace, Enrico M, Sun, Junwei, Redmond, T Michael, Zhu, Xiaosong, Shindler, Kenneth S, Ying, Gui-Shuang, Ziviello, Carmela, Acerra, Carmela, Wright, J Fraser, McDonnell, Jennifer Wellman, High, Katherine A, Bennett, Jean, Auricchio, Alberto
Publicado 2009