Quantitative characterization of the mechanism of action and impact of a ‘proteolysis-permitting’ anti-PCSK9 antibody

por Hansen, Ryan J., Berna, Michael J., Sperry, Andrea E., Beyer, Thomas P., Wroblewski, Victor J., Schroeder, Krista M., Eacho, Patrick I.
Publicado 2016

Generation and characterization of ixekizumab, a humanized monoclonal antibody that neutralizes interleukin-17A

por Liu, Ling, Lu, Jirong, Allan, Barrett W, Tang, Ying, Tetreault, Jonathan, Chow, Chi-kin, Barmettler, Barbra, Nelson, James, Bina, Holly, Huang, Lihua, Wroblewski, Victor J, Kikly, Kristine
Publicado 2016

Distinct mobilization of leukocytes and hematopoietic stem cells by CXCR4 peptide antagonist LY2510924 and monoclonal antibody LY2624587

por Peng, Sheng-Bin, Van Horn, Robert D., Yin, Tinggui, Brown, Robin M., Roell, William C., Obungu, Victor H., Ruegg, Charles, Wroblewski, Victor J., Raddad, Eyas, Stille, John R.
Publicado 2017

LY2405319, an Engineered FGF21 Variant, Improves the Metabolic Status of Diabetic Monkeys

por Adams, Andrew C., Halstead, Carolyn A., Hansen, Barbara C., Irizarry, Armando R., Martin, Jennifer A., Myers, Sharon R., Reynolds, Vincent L., Smith, Holly W., Wroblewski, Victor J., Kharitonenkov, Alexei
Publicado 2013

A decoy receptor 3 analogue reduces localised defects in phagocyte function in pneumococcal pneumonia

por Marriott, Helen M, Daigneault, Marc, Thompson, Alfred A R, Walmsley, Sarah R, Gill, Sharonjit K, Witcher, Derrick R, Wroblewski, Victor J, Hellewell, Paul G, Whyte, Moira K B, Dockrell, David H
Publicado 2012

Rational Design of a Fibroblast Growth Factor 21-Based Clinical Candidate, LY2405319

por Kharitonenkov, Alexei, Beals, John M., Micanovic, Radmila, Strifler, Beth A., Rathnachalam, Radhakrishnan, Wroblewski, Victor J., Li, Shun, Koester, Anja, Ford, Amy M., Coskun, Tamer, Dunbar, James D., Cheng, Christine C., Frye, Christopher C., Bumol, Thomas F., Moller, David E.
Publicado 2013

A bi-functional antibody-receptor domain fusion protein simultaneously targeting IGF-IR and VEGF for degradation

por Shen, Yang, Zeng, Lin, Novosyadlyy, Ruslan, Forest, Amelie, Zhu, Aiping, Korytko, Andrew, Zhang, Haifan, Eastman, Scott W, Topper, Michael, Hindi, Sagit, Covino, Nicole, Persaud, Kris, Kang, Yun, Burtrum, Douglas, Surguladze, David, Prewett, Marie, Chintharlapalli, Sudhakar, Wroblewski, Victor J, Shen, Juqun, Balderes, Paul, Zhu, Zhenping, Snavely, Marshall, Ludwig, Dale L
Publicado 2015