Good guide, bad guide: spacer sequence-dependent cleavage efficiency of Cas12a

por Creutzburg, Sjoerd C A, Wu, Wen Y, Mohanraju, Prarthana, Swartjes, Thomas, Alkan, Ferhat, Gorodkin, Jan, Staals, Raymond H J, van der Oost, John
Publicado 2020

Adaptation by Type V-A and V-B CRISPR-Cas Systems Demonstrates Conserved Protospacer Selection Mechanisms Between Diverse CRISPR-Cas Types

por Wu, Wen Y., Jackson, Simon A., Almendros, Cristóbal, Haagsma, Anna C., Yilmaz, Suzan, Gort, Gerrit, van der Oost, John, Brouns, Stan J.J., Staals, Raymond H.J.
Publicado 2022

Mechanistic and evolutionary insights into a type V-M CRISPR–Cas effector enzyme

por Omura, Satoshi N., Nakagawa, Ryoya, Südfeld, Christian, Villegas Warren, Ricardo, Wu, Wen Y., Hirano, Hisato, Laffeber, Charlie, Kusakizako, Tsukasa, Kise, Yoshiaki, Lebbink, Joyce H. G., Itoh, Yuzuru, van der Oost, John, Nureki, Osamu
Publicado 2023

Multiplex gene editing by CRISPR-Cpf1 through autonomous processing of a single crRNA array

por Zetsche, Bernd, Heidenreich, Matthias, Mohanraju, Prarthana, Fedorova, Iana, Kneppers, Jeroen, DeGennaro, Ellen M., Winblad, Nerges, Choudhury, Sourav R., Abudayyeh, Omar O., Gootenberg, Jonathan S., Wu, Wen Y., Scott, David A., Severinov, Konstantin, van der Oost, John, Zhang, Feng
Publicado 2016

Cryo-EM structure of the transposon-associated TnpB enzyme

por Nakagawa, Ryoya, Hirano, Hisato, Omura, Satoshi N., Nety, Suchita, Kannan, Soumya, Altae-Tran, Han, Yao, Xiao, Sakaguchi, Yuriko, Ohira, Takayuki, Wu, Wen Y., Nakayama, Hiroshi, Shuto, Yutaro, Tanaka, Tatsuki, Sano, Fumiya K., Kusakizako, Tsukasa, Kise, Yoshiaki, Itoh, Yuzuru, Dohmae, Naoshi, van der Oost, John, Suzuki, Tsutomu, Zhang, Feng, Nureki, Osamu
Publicado 2023