Structure-based discovery of orally efficient inhibitors via unique interactions with H-pocket of PDE8 for the treatment of vascular dementia

por Wu, Xu-Nian, Zhou, Qian, Huang, Ya-Dan, Xie, Xi, Li, Zhe, Wu, Yinuo, Luo, Hai-Bin
Publicado 2022

Discovery of novel PDE9A inhibitors with antioxidant activities for treatment of Alzheimer’s disease

por Zhang, Chen, Zhou, Qian, Wu, Xu-Nian, Huang, Ya-Dan, Zhou, Jie, Lai, Zengwei, Wu, Yinuo, Luo, Hai-Bin
Publicado 2017

Structure-based design, synthesis, and biological evaluation of novel pyrimidinone derivatives as PDE9 inhibitors

por Wu, Xu-Nian, Huang, Ya-Dan, Li, Jin-Xuan, Yu, Yan-Fa, Qian, Zhou, Zhang, Chen, Wu, Yinuo, Luo, Hai-Bin
Publicado 2018

Free energy perturbation (FEP)-guided scaffold hopping

por Wu, Deyan, Zheng, Xuehua, Liu, Runduo, Li, Zhe, Jiang, Zan, Zhou, Qian, Huang, Yue, Wu, Xu-Nian, Zhang, Chen, Huang, Yi-You, Luo, Hai-Bin
Publicado 2022

A novel inhibitor of N(6)-methyladenosine demethylase FTO induces mRNA methylation and shows anti-cancer activities

por Xie, Guoyou, Wu, Xu-Nian, Ling, Yuyi, Rui, Yalan, Wu, Deyan, Zhou, Jiawang, Li, Jiexin, Lin, Shuibin, Peng, Qin, Li, Zigang, Wang, Hongsheng, Luo, Hai-Bin
Publicado 2022