Targeted Gene Disruption Reveals an Adhesin Indispensable for Pathogenicity of Blastomyces dermatitidis

por Tristan Brandhorst, T., Wüthrich, Marcel, Warner, Thomas, Klein, Bruce
Publicado 1999

Vaccine Immunity to Pathogenic Fungi Overcomes the Requirement for CD4 Help in Exogenous Antigen Presentation to CD8(+) T Cells: Implications for Vaccine Development in Immune-defi...

por Wüthrich, Marcel, Filutowicz, Hanna I., Warner, Tom, Deepe, George S., Klein, Bruce S.
Publicado 2003

Tc17 Cells Mediate Vaccine Immunity against Lethal Fungal Pneumonia in Immune Deficient Hosts Lacking CD4(+) T Cells

por Nanjappa, Som Gowda, Heninger, Erika, Wüthrich, Marcel, Gasper, David Joseph, Klein, Bruce S.
Publicado 2012

The Eng1 β-Glucanase Enhances Histoplasma Virulence by Reducing β-Glucan Exposure

por Garfoot, Andrew L., Shen, Qian, Wüthrich, Marcel, Klein, Bruce S., Rappleye, Chad A.
Publicado 2016

Characterization of C-type lectins reveals an unexpectedly limited interaction between Cryptococcus neoformans spores and Dectin-1

por Walsh, Naomi M., Wuthrich, Marcel, Wang, Huafeng, Klein, Bruce, Hull, Christina M.
Publicado 2017

Intrinsic MyD88-Akt1-mTOR Signaling Coordinates Disparate Tc17 and Tc1 Responses during Vaccine Immunity against Fungal Pneumonia

por Nanjappa, Som Gowda, Hernández-Santos, Nydiaris, Galles, Kevin, Wüthrich, Marcel, Suresh, M., Klein, Bruce S.
Publicado 2015

Fonsecaea pedrosoi‐induced Th17‐cell differentiation in mice is fostered by Dectin‐2 and suppressed by Mincle recognition

por Wüthrich, Marcel, Wang, Huafeng, Li, Mengyi, Lerksuthirat, Tassanee, Hardison, Sarah E., Brown, Gordon D., Klein, Bruce
Publicado 2015

Transcription Factor KLF2 in Dendritic Cells Downregulates Th2 Programming via the HIF-1α/Jagged2/Notch Axis

por Xiong, Ye, Lingrel, Jerry B., Wüthrich, Marcel, Klein, Bruce S., Vasudevan, Neelakantan T., Jain, Mukesh K., George, Mariam, Deepe, George S.
Publicado 2016

Antifungal Tc17 cells are durable and stable, persisting as long-lasting vaccine memory without plasticity towards IFNγ cells

por Nanjappa, Som Gowda, McDermott, Andrew J., Fites, J. Scott, Galles, Kevin, Wüthrich, Marcel, Deepe, George S., Klein, Bruce S.
Publicado 2017

O-Mannosylation of Proteins Enables Histoplasma Yeast Survival at Mammalian Body Temperatures

por Garfoot, Andrew L., Goughenour, Kristie D., Wüthrich, Marcel, Rajaram, Murugesan V. S., Schlesinger, Larry S., Klein, Bruce S., Rappleye, Chad A.
Publicado 2018

Distinctive populations of CD4(+)T cells associated with vaccine efficacy

por Woodring, Therese, Dewey, Colin N., Santos Dias, Lucas Dos, He, Xin, Dobson, Hannah E., Wüthrich, Marcel, Klein, Bruce
Publicado 2022

Complement Component 3C3 and C3a Receptor Are Required in Chitin-Dependent Allergic Sensitization to Aspergillus fumigatus but Dispensable in Chitin-Induced Innate Allergic Inflamm...

por Roy, René M., Paes, Hugo C., Nanjappa, Som G., Sorkness, Ron, Gasper, David, Sterkel, Alana, Wüthrich, Marcel, Klein, Bruce S.
Publicado 2013

CRISPR/Cas9-Mediated Gene Disruption Reveals the Importance of Zinc Metabolism for Fitness of the Dimorphic Fungal Pathogen Blastomyces dermatitidis

por Kujoth, Gregory C., Sullivan, Thomas D., Merkhofer, Richard, Lee, Taek-Jin, Wang, Huafeng, Brandhorst, Tristan, Wüthrich, Marcel, Klein, Bruce S.
Publicado 2018

Ligation of Dectin-2 with a novel microbial ligand promotes adjuvant activity for vaccination

por Wang, Huafeng, Lee, Taek-Jin, Fites, Scott J., Merkhofer, Richard, Zarnowski, Robert, Brandhorst, Tristan, Galles, Kevin, Klein, Bruce, Wüthrich, Marcel
Publicado 2017

Infectious particle identity determines dissemination and disease outcome for the inhaled human fungal pathogen Cryptococcus

por Walsh, Naomi M., Botts, Michael R., McDermott, Andrew J., Ortiz, Sébastien C., Wüthrich, Marcel, Klein, Bruce, Hull, Christina M.
Publicado 2019

Variation in Host Resistance to Blastomyces dermatitidis: Potential Use of Genetic Reference Panels and Advances in Immunophenotyping of Diverse Mouse Strains

por Kohn, Elaine M., Taira, Cleison, Dobson, Hanah, Dias, Lucas Dos Santos, Okaa, Uju, Wiesner, Darin L., Wüthrich, Marcel, Klein, Bruce S.
Publicado 2022

Structure and Function of a Fungal Adhesin that Binds Heparin and Mimics Thrombospondin-1 by Blocking T Cell Activation and Effector Function

por Brandhorst, T. Tristan, Roy, René, Wüthrich, Marcel, Nanjappa, Som, Filutowicz, Hanna, Galles, Kevin, Tonelli, Marco, McCaslin, Darrell R., Satyshur, Kenneth, Klein, Bruce
Publicado 2013

Combination Adjuvants Enhance Recombinant Protein Vaccine Protection against Fungal Infection

por Wüthrich, Marcel, Dobson, Hannah E., Ledesma Taira, Cleison, Okaa, Uju Joy, dos Santos Dias, Lucas, Isidoro-Ayza, Marcos, Petrovsky, Nikolai, Klein, Bruce S.
Publicado 2021

Novel Strategies to Enhance Vaccine Immunity against Coccidioidomycosis

por Cole, Garry T., Hung, Chiung-Yu, Sanderson, Sam D., Hurtgen, Brady J., Wüthrich, Marcel, Klein, Bruce S., Deepe, George S., Ostroff, Gary R., Levitz, Stuart M.
Publicado 2013

Early immune response against Fonsecaea pedrosoi requires Dectin-2-mediated Th17 activity, whereas Th1 response, aided by Treg cells, is crucial for fungal clearance in later stage...

por Siqueira, Isaque Medeiros, Wüthrich, Marcel, Li, Mengyi, Wang, Huafeng, Las-Casas, Lucas de Oliveira, de Castro, Raffael Júnio Araújo, Klein, Bruce, Bocca, Anamelia Lorenzetti
Publicado 2020