Identification and structure solution of fragment hits against kinetoplastid N-myristoyltransferase

por Robinson, David A., Wyatt, Paul G.
Publicado 2015

Ligand binding: evaluating the contribution of the water molecules network using the Fragment Molecular Orbital method

por Lukac, Iva, Wyatt, Paul G., Gilbert, Ian H., Zuccotto, Fabio
Publicado 2021

Exercise induced Right Ventricular Fibrosis is Associated with Myocardial Damage and Inflammation

por Rao, Zhijian, Wang, Shiqiang, Bunner, Wyatt Paul, Chang, Yun, Shi, Rengfei
Publicado 2018

Target Validation: Linking Target and Chemical Properties to Desired Product Profile

por Wyatt, Paul G, Gilbert, Ian H, Read, Kevin D, Fairlamb, Alan H
Publicado 2011

The Design and Synthesis of Potent and Selective Inhibitors of Trypanosoma brucei Glycogen Synthase Kinase 3 for the Treatment of Human African Trypanosomiasis

por Urich, Robert, Grimaldi, Raffaella, Luksch, Torsten, Frearson, Julie A., Brenk, Ruth, Wyatt, Paul G.
Publicado 2014

Correction to “Bespoke Drug Discovery Training for Low-Middle Income Countries”

por Webster, Lauren A., Farrell, Susan J., Gilbert, Ian H., Wyatt, Paul G., Read, Kevin D.
Publicado 2023

Nuclear DBF-2-related Kinases Are Essential Regulators of Cytokinesis in Bloodstream Stage Trypanosoma brucei

por Ma, Jiangtao, Benz, Corinna, Grimaldi, Raffaella, Stockdale, Christopher, Wyatt, Paul, Frearson, Julie, Hammarton, Tansy C.
Publicado 2010

Antitumor Quinol PMX464 Is a Cytocidal Anti-trypanosomal Inhibitor Targeting Trypanothione Metabolism

por König, Janine, Wyllie, Susan, Wells, Geoffrey, Stevens, Malcolm F., Wyatt, Paul G., Fairlamb, Alan H.
Publicado 2011

Lessons Learnt from Assembling Screening Libraries for Drug Discovery for Neglected Diseases

por Brenk, Ruth, Schipani, Alessandro, James, Daniel, Krasowski, Agata, Gilbert, Ian Hugh, Frearson, Julie, Wyatt, Paul Graham
Publicado 2008

Synthesis and Evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) Analogues as Inhibitors of Trypanothione Reductase

por Patterson, Stephen, Jones, Deuan C, Shanks, Emma J, Frearson, Julie A, Gilbert, Ian H, Wyatt, Paul G, Fairlamb, Alan H
Publicado 2009

De Novo Design of Protein Kinase Inhibitors by in Silico Identification of Hinge Region-Binding Fragments

por Urich, Robert, Wishart, Grant, Kiczun, Michael, Richters, André, Tidten-Luksch, Naomi, Rauh, Daniel, Sherborne, Brad, Wyatt, Paul G., Brenk, Ruth
Publicado 2013

A Target Repurposing Approach Identifies N-myristoyltransferase as a New Candidate Drug Target in Filarial Nematodes

por Galvin, Brendan D., Li, Zhiru, Villemaine, Estelle, Poole, Catherine B., Chapman, Melissa S., Pollastri, Michael P., Wyatt, Paul G., Carlow, Clotilde K. S.
Publicado 2014

Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors

por Spinks, Daniel, Torrie, Leah S, Thompson, Stephen, Harrison, Justin R, Frearson, Julie A, Read, Kevin D, Fairlamb, Alan H, Wyatt, Paul G, Gilbert, Ian H
Publicado 2012

Chemical Proteomic Analysis Reveals the Drugability of the Kinome of Trypanosoma brucei

por Urbaniak, Michael D., Mathieson, Toby, Bantscheff, Marcus, Eberhard, Dirk, Grimaldi, Raffaella, Miranda-Saavedra, Diego, Wyatt, Paul, Ferguson, Michael A. J., Frearson, Julie, Drewes, Gerard
Publicado 2012

Clinically relevant enhancement of human sperm motility using compounds with reported phosphodiesterase inhibitor activity

por Tardif, Steve, Madamidola, Oladipo A., Brown, Sean G., Frame, Lorna, Lefièvre, Linda, Wyatt, Paul G., Barratt, Christopher L.R., Martins Da Silva, Sarah J.
Publicado 2014

Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallo...

por Patterson, Stephen, Alphey, Magnus S., Jones, Deuan C., Shanks, Emma J., Street, Ian P., Frearson, Julie A., Wyatt, Paul G., Gilbert, Ian H., Fairlamb, Alan H.
Publicado 2011

Structure–Activity Relationship Studies of Pyrrolone Antimalarial Agents

por Murugesan, Dinakaran, Kaiser, Marcel, White, Karen L, Norval, Suzanne, Riley, Jennifer, Wyatt, Paul G, Charman, Susan A, Read, Kevin D, Yeates, Clive, Gilbert, Ian H
Publicado 2013

Chemical Validation of Trypanothione Synthetase: A POTENTIAL DRUG TARGET FOR HUMAN TRYPANOSOMIASIS

por Torrie, Leah S., Wyllie, Susan, Spinks, Daniel, Oza, Sandra L., Thompson, Stephen, Harrison, Justin R., Gilbert, Ian H., Wyatt, Paul G., Fairlamb, Alan H., Frearson, Julie A.
Publicado 2009

Investigation of Trypanothione Reductase as a Drug Target in Trypanosoma brucei

por Spinks, Daniel, Shanks, Emma J, Cleghorn, Laura A T, McElroy, Stuart, Jones, Deuan, James, Daniel, Fairlamb, Alan H, Frearson, Julie A, Wyatt, Paul G, Gilbert, Ian H
Publicado 2009

From On-Target to Off-Target Activity: Identification and Optimisation of Trypanosoma brucei GSK3 Inhibitors and Their Characterisation as Anti-Trypanosoma brucei Drug Discovery Le...

por Woodland, Andrew, Grimaldi, Raffaella, Luksch, Torsten, Cleghorn, Laura A T, Ojo, Kayode K, Van Voorhis, Wesley C, Brenk, Ruth, Frearson, Julie A, Gilbert, Ian H, Wyatt, Paul G
Publicado 2013