Safety, pharmacokinetics and efficacy of SCT200, an anti-EGFR monoclonal antibody in patients with wild-type KRAS/NRAS/BRAF metastatic colorectal cancer: a phase I dose-escalation...

por Zhang, Wen, Han, Xiaohong, Yang, Lin, Song, Yuanyuan, Xie, Liangzhi, Gai, Wenlin, Wang, Yan, Shi, Yuankai
Publicado 2022

Safety and immunogenicity of a bivalent SARS-CoV-2 protein booster vaccine, SCTV01C in adults previously vaccinated with inactivated vaccine: A randomized, double-blind, placebo-co...

por Hannawi, Suad, Saifeldin, Linda, Abuquta, Alaa, Alamadi, Ahmad, Mahmoud, Sally A., Li, Jian, Chen, Yuanxin, Xie, Liangzhi
Publicado 2022

A Randomized, Double-Blind, Parallel-Controlled Phase I Study Comparing the Pharmacokinetics, Safety, and Immunogenicity of SCT510 to Bevacizumab (Avastin(®)) in Healthy Chinese Ma...

por Wu, Jing, Wu, Guolan, Xie, Liangzhi, Lv, Duo, Xu, Chang, Zhou, Huili, Wu, Lihua, Zhang, Jingjing, Shentu, Jianzhong
Publicado 2023

Safety and efficacy of anti-EGFR monoclonal antibody (SCT200) as second-line therapy in advanced esophageal squamous cell carcinoma

por Bai, Ming, Wang, Meng, Deng, Ting, Bai, Yuxian, Zang, Kai, Miao, Zhanhui, Gai, Wenlin, Xie, Liangzhi, Ba, Yi
Publicado 2022

Safety and immunogenicity of a bivalent SARS-CoV-2 protein booster vaccine, SCTV01C, in adults previously vaccinated with mRNA vaccine: A randomized, double-blind, placebo-controll...

por Hannawi, Suad, Saifeldin, Linda, Abuquta, Alaa, Alamadi, Ahmad, Mahmoud, Sally A., Hassan, Aala, Liu, Dongfang, Yan, Lixin, Xie, Liangzhi
Publicado 2022

Immunogenicity correlation in cynomolgus monkeys between Luminex‐based total IgG immunoassay and pseudovirion‐based neutralization assay for a 14‐valent recombinant human papilloma...

por Bei, Lei, Zhang, Xiao, Meng, Dan, Gao, Shuman, Jia, Jilei, Zhao, Dandan, Luo, Chunxia, Li, Xuefeng, Qiu, Hongbin, Xie, Liangzhi
Publicado 2022

Mutation N856K in spike reduces fusogenicity and infectivity of Omicron BA.1

por Sun, Chunyun, Wang, Huiyu, Yang, Ji, Kong, Desheng, Chen, Yuning, Wang, Haiyue, Sun, Lingling, Lu, Jianbo, Teng, Min, Xie, Liangzhi
Publicado 2023

A Polysaccharide-RBD-Fc-Conjugated COVID-19 Vaccine, SCTV01A, Showed High Immunogenicity and Low Toxicity in Animal Models

por Sun, Chunyun, Kong, Desheng, Guo, Erhong, Zhao, Jun, Jia, Jilei, Wang, Rui, Ma, Juan, Chen, Meng, Lu, Jianbo, Yu, Chulin, Li, Kuokuo, Xie, Liangzhi
Publicado 2023

Intranasal Immunization with Recombinant HA and Mast Cell Activator C48/80 Elicits Protective Immunity against 2009 Pandemic H1N1 Influenza in Mice

por Meng, Shu, Liu, Zhonghua, Xu, Lili, Li, Li, Mei, Shan, Bao, Linlin, Deng, Wei, Li, Lina, Lei, Rongyue, Xie, Liangzhi, Qin, Chuan, Zhang, Linqi
Publicado 2011

Safety and immunogenicity of multivalent SARS-CoV-2 protein vaccines: a randomized phase 3 trial

por Hannawi, Suad, Yan, Lixin, Saifeldin, Linda, Abuquta, Alaa, Alamadi, Ahmad, Mahmoud, Sally A., Hassan, Aala, Zhang, Miaomiao, Gao, Cuige, Chen, Yuanxin, Gai, Wenlin, Xie, Liangzhi
Publicado 2023

Phase I study of chimeric anti-CD20 monoclonal antibody in Chinese patients with CD20-positive non-Hodgkin's lymphoma

por Gui, Lin, Han, Xiaohong, He, Xiaohui, Song, Yuanyuan, Yao, Jiarui, Yang, Jianliang, Liu, Peng, Qin, Yan, Zhang, Shuxiang, Zhang, Weijing, Gai, Wenlin, Xie, Liangzhi, Shi, Yuankai
Publicado 2016

Antibody-dependent-cellular-cytotoxicity-inducing antibodies significantly affect the post-exposure treatment of Ebola virus infection

por Liu, Qiang, Fan, Changfa, Li, Qianqian, Zhou, Shuya, Huang, Weijin, Wang, Lan, Sun, Chunyun, Wang, Meng, Wu, Xi, Ma, Jian, Li, Baowen, Xie, Liangzhi, Wang, Youchun
Publicado 2017

Quantification of SARS-CoV-2 antigen levels in the blood of patients with COVID-19

por Su, Bin, Yin, Jiming, Lin, Xingguang, Zhang, Tiantian, Yao, Xiao, Xu, Ying, Lu, Yao, Wang, Wenzhi, Liu, Kun, Zhang, Jie, Xie, Liangzhi, Jin, Ronghua, Feng, Yingmei
Publicado 2020

An antibody cocktail with broadened mutational resistance and effective protection against SARS-CoV-2

por Sun, Chunyun, Chi, Hang, Yuan, Fei, Li, Jing, Yang, Ji, Zheng, Aihua, Wang, Fei, Sun, Lingling, Zhang, Yanjing, Hu, Ping, Jiao, Lihua, Deng, Yongqiang, Xie, Liangzhi
Publicado 2022

Feasibility Studies of Nebulized SARS-CoV-2 Neutralizing Antibody in Mice and Cynomolgus Monkeys

por Jia, Jilei, Yin, Zhaojuan, Zhang, Xiao, Li, Huimin, Meng, Dan, Liu, Qianqian, Wang, Hongfang, Han, Meng, Suo, Shixiang, Liu, Yan, Hu, Ping, Sun, Chunyun, Li, Jing, Xie, Liangzhi
Publicado 2022

Safety and immunogenicity of a bivalent SARS-CoV-2 recombinant protein vaccine, SCTV01C in unvaccinated adults: A randomized, double-blinded, placebo-controlled, phase I clinical t...

por Wang, Guiqiang, Zhao, Kexin, Han, Jun, Hu, Zhongyu, Zhang, Tianzuo, Wang, Yanchao, Shi, Rui, Li, Yanhua, Song, Qinqin, Du, Haijun, He, Peng, Xu, Shuping, Yang, Xinjie, Fu, Yongpan, Cui, Yimin, Xie, Liangzhi
Publicado 2022

A spike-trimer protein-based tetravalent COVID-19 vaccine elicits enhanced breadth of neutralization against SARS-CoV-2 Omicron subvariants and other variants

por Wang, Rui, Huang, Hongpeng, Yu, Chulin, Sun, Chunyun, Ma, Juan, Kong, Desheng, Lin, Yalong, Zhao, Dandan, Zhou, Shaozheng, Lu, Jianbo, Cao, Sai, Zhang, Yanjing, Luo, Chunxia, Li, Xuefeng, Wang, Yang, Xie, Liangzhi
Publicado 2022

Safety and immunogenicity of a tetravalent and bivalent SARS-CoV-2 protein booster vaccine in men

por Hannawi, Suad, Saifeldin, Linda, Abuquta, Alaa, Alamadi, Ahmad, Mahmoud, Sally A., Hassan, Aala, Xu, Shuping, Li, Jian, Liu, Dongfang, Baidoo, Adam Abdul Hakeem, Ibrahim, Dima, Alhaj, Mojtaba, Chen, Yuanxin, Zhou, Qiang, Xie, Liangzhi
Publicado 2023

Safety, Tolerability, Pharmacokinetics, and Immunogenicity of a Monoclonal Antibody (SCTA01) Targeting SARS-CoV-2 in Healthy Adults: a Randomized, Double-Blind, Placebo-Controlled,...

por Li, Yinjuan, Qi, Lu, Bai, Haihong, Sun, Chunyun, Xu, Shuping, Wang, Yu, Han, Chunyu, Li, Yan, Liu, Long, Cheng, Xiaoqiang, Liu, Ju, Lei, Chunpu, Tong, Yuanxu, Sun, Mingli, Yan, Lixin, Chen, Weiqiu, Liu, Xisheng, Liu, Qing, Xie, Liangzhi, Wang, Xinghe
Publicado 2021

A Bivalent COVID-19 Vaccine Based on Alpha and Beta Variants Elicits Potent and Broad Immune Responses in Mice against SARS-CoV-2 Variants

por Wang, Rui, Sun, Chunyun, Ma, Juan, Yu, Chulin, Kong, Desheng, Chen, Meng, Liu, Xuejie, Zhao, Dandan, Gao, Shuman, Kou, Shuyuan, Sun, Lili, Ge, Zeyong, Zhao, Jun, Li, Kuokuo, Zhang, Tao, Zhang, Yanjing, Luo, Chunxia, Li, Xuefeng, Wang, Yang, Xie, Liangzhi
Publicado 2022