Synthesis and anti-SARS-CoV-2 activity of deuterated GS-441524 analogs

por Zheng, Wei, Hu, Tianwen, Zhang, Yumin, Wei, Daibao, Xie, Yuanchao, Shen, Jingshan
Publicado 2022

Practical and Highly Efficient Synthesis of Remdesivir from GS-441524

por Hu, Tianwen, Zhu, Fuqiang, Xiang, Li, Shen, Jingshan, Xie, Yuanchao, Aisa, Haji A.
Publicado 2022

Challenges and stepwise fit-for-purpose optimization for bioanalyses of remdesivir metabolites nucleotide monophosphate and triphosphate in mouse tissues using LC–MS/MS

por Hu, Wenjuan, Chang, Lu, Ke, Changqiang, Xie, Yuanchao, Shen, Jingshan, Tan, Bo, Liu, Jia
Publicado 2021

Significant Inhibition of Porcine Epidemic Diarrhea Virus In Vitro by Remdesivir, Its Parent Nucleoside and β-d-N(4)-hydroxycytidine

por Xie, Yuanchao, Guo, Xiaozhen, Hu, Tianwen, Wei, Daibao, Ma, Xiuli, Wu, Jiaqiang, Huang, Bing, Shen, Jingshan
Publicado 2021

Potency and pharmacokinetics of GS-441524 derivatives against SARS-CoV-2

por Wei, Daibao, Hu, Tianwen, Zhang, Yumin, Zheng, Wei, Xue, Haitao, Shen, Jingshan, Xie, Yuanchao, Aisa, Haji A.
Publicado 2021

A viral RNA-dependent RNA polymerase inhibitor VV116 broadly inhibits human coronaviruses and has synergistic potency with 3CLpro inhibitor nirmatrelvir

por Zhang, Yumin, Sun, Yuan, Xie, Yuanchao, Shang, Weijuan, Wang, Zhen, Jiang, Hualiang, Shen, Jingshan, Xiao, Gengfu, Zhang, Leike
Publicado 2023

Oral remdesivir derivative VV116 is a potent inhibitor of respiratory syncytial virus with efficacy in mouse model

por Zhang, Ruxue, Zhang, Yumin, Zheng, Wei, Shang, Weijuan, Wu, Yan, Li, Ning, Xiong, Jun, Jiang, Hualiang, Shen, Jingshan, Xiao, Gengfu, Xie, Yuanchao, Zhang, Leike
Publicado 2022

Design and development of an oral remdesivir derivative VV116 against SARS-CoV-2

por Xie, Yuanchao, Yin, Wanchao, Zhang, Yumin, Shang, Weijuan, Wang, Zhen, Luan, Xiaodong, Tian, Guanghui, Aisa, Haji A., Xu, Yechun, Xiao, Gengfu, Li, Jia, Jiang, Hualiang, Zhang, Shuyang, Zhang, Leike, Xu, H. Eric, Shen, Jingshan
Publicado 2021