RNA-dependent RNA polymerase: Structure, mechanism, and drug discovery for COVID-19

por Jiang, Yi, Yin, Wanchao, Xu, H. Eric
Publicado 2021

A Highly Sensitive Non-Radioactive Activity Assay for AMP-Activated Protein Kinase (AMPK)

por Yan, Yan, Gu, Xin, Xu, H. Eric, Melcher, Karsten
Publicado 2017

Defining the minimum substrate and charge recognition model of gamma-secretase

por Yan, Yan, Xu, Ting-Hai, Melcher, Karsten, Xu, H Eric
Publicado 2017

Structure and Physiological Regulation of AMPK

por Yan, Yan, Zhou, X. Edward, Xu, H. Eric, Melcher, Karsten
Publicado 2018

Crystal Structure of the PAC1R Extracellular Domain Unifies a Consensus Fold for Hormone Recognition by Class B G-Protein Coupled Receptors

por Kumar, Shiva, Pioszak, Augen, Zhang, Chenghai, Swaminathan, Kunchithapadam, Xu, H. Eric
Publicado 2011

Structure genomics of SARS-CoV-2 and its Omicron variant: drug design templates for COVID-19

por Wu, Can-rong, Yin, Wan-chao, Jiang, Yi, Xu, H. Eric
Publicado 2022

Ion channels gated by acetylcholine and serotonin: structures, biology, and drug discovery

por Wu, Zhong-shan, Cheng, Hao, Jiang, Yi, Melcher, Karsten, Xu, H Eric
Publicado 2015

EZH2: biology, disease, and structure-based drug discovery

por Tan, Jin-zhi, Yan, Yan, Wang, Xiao-xi, Jiang, Yi, Xu, H Eric
Publicado 2014

Androgen receptor: structure, role in prostate cancer and drug discovery

por Tan, MH Eileen, Li, Jun, Xu, H Eric, Melcher, Karsten, Yong, Eu-leong
Publicado 2015

OR30-3 Structural Basis of Activation and Sustained Signaling by the PTH Receptor

por Sutkeviciute, Ieva, Zhao, Li-Hua, Zhang, Yan, Xu, H Eric, Vilardaga, Jean-Pierre
Publicado 2019

Alzheimer’s disease-associated mutations increase amyloid precursor protein resistance to γ-secretase cleavage and the Aβ42/Aβ40 ratio

por Xu, Ting-Hai, Yan, Yan, Kang, Yanyong, Jiang, Yi, Melcher, Karsten, Xu, H Eric
Publicado 2016

Molecular recognition of itch-associated neuropeptides by bombesin receptors

por Li, Changyao, Xu, Youwei, Liu, Heng, Cai, Hongmin, Jiang, Yi, Xu, H. Eric, Yin, Wanchao
Publicado 2022

H(2)O(2) Inhibits ABA-Signaling Protein Phosphatase HAB1

por Sridharamurthy, Madhuri, Kovach, Amanda, Zhao, Yang, Zhu, Jian-Kang, Xu, H. Eric, Swaminathan, Kunchithapadam, Melcher, Karsten
Publicado 2014

Dimerization of the transmembrane domain of amyloid precursor protein is determined by residues around the γ-secretase cleavage sites

por Yan, Yan, Xu, Ting-Hai, Harikumar, Kaleeckal G., Miller, Laurence J., Melcher, Karsten, Xu, H. Eric
Publicado 2017

Abscisic Acid Signaling: Thermal Stability Shift Assays as Tool to Analyze Hormone Perception and Signal Transduction

por Soon, Fen-Fen, Suino-Powell, Kelly M., Li, Jun, Yong, Eu-Leong, Xu, H. Eric, Melcher, Karsten
Publicado 2012

Structural basis for recognition of diverse transcriptional repressors by the TOPLESS family of corepressors

por Ke, Jiyuan, Ma, Honglei, Gu, Xin, Thelen, Adam, Brunzelle, Joseph S., Li, Jiayang, Xu, H. Eric, Melcher, Karsten
Publicado 2015

Identification of a novel selective PPARγ ligand with a unique binding mode and improved therapeutic profile in vitro

por Yi, Wei, Shi, Jingjing, Zhao, Guanguan, Zhou, X. Edward, Suino-Powell, Kelly, Melcher, Karsten, Xu, H. Eric
Publicado 2017

Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2

por Zhuang, Youwen, Wang, Lei, Guo, Jia, Sun, Dapeng, Wang, Yue, Liu, Weiyi, Xu, H. Eric, Zhang, Cheng
Publicado 2022

The Potent Cdc7-Dbf4 (DDK) Kinase Inhibitor XL413 Has Limited Activity in Many Cancer Cell Lines and Discovery of Potential New DDK Inhibitor Scaffolds

por Sasi, Nanda Kumar, Tiwari, Kanchan, Soon, Fen-Fen, Bonte, Dorine, Wang, Tong, Melcher, Karsten, Xu, H. Eric, Weinreich, Michael
Publicado 2014

Structural insights into the ligand binding and G(i) coupling of serotonin receptor 5-HT(5A)

por Tan, Yangxia, Xu, Peiyu, Huang, Sijie, Yang, Gong, Zhou, Fulai, He, Xinheng, Ma, Honglei, Xu, H. Eric, Jiang, Yi
Publicado 2022