Arginine metabolism in Trichomonas vaginalis infected with Mycoplasma hominis

por Morada, Mary, Manzur, Mafruha, Lam, Brian, Tan, Cho, Tachezy, Jan, Rappelli, Paola, Dessì, Daniele, Fiori, Pier L., Yarlett, Nigel
Publicado 2010

2,4-Diaminopyrimidines as Potent Inhibitors of Trypanosoma brucei and Identification of Molecular Targets by a Chemical Proteomics Approach

por Mercer, Luke, Bowling, Tana, Perales, Joe, Freeman, Jennifer, Nguyen, Tien, Bacchi, Cyrus, Yarlett, Nigel, Don, Robert, Jacobs, Robert, Nare, Bakela
Publicado 2011

Alkanediamide-Linked Bisbenzamidines Are Promising Antiparasitic Agents

por Vanden Eynde, Jean J., Mayence, Annie, Mottamal, Madhusoodanan, Bacchi, Cyrus J., Yarlett, Nigel, Kaiser, Marcel, Brun, Reto, Huang, Tien L.
Publicado 2016

Novel Synthetic Polyamines Have Potent Antimalarial Activities in vitro and in vivo by Decreasing Intracellular Spermidine and Spermine Concentrations

por El Bissati, Kamal, Redel, Henry, Ting, Li-Min, Lykins, Joseph D., McPhillie, Martin J., Upadhya, Rajendra, Woster, Patrick M., Yarlett, Nigel, Kim, Kami, Weiss, Louis M.
Publicado 2019

Pharmacokinetics and pharmacodynamics utilizing unbound target tissue exposure as part of a disposition-based rationale for lead optimization of benzoxaboroles in the treatment of...

por WRING, STEPHEN, GAUKEL, ERIC, NARE, BAKELA, JACOBS, ROBERT, BEAUDET, BETH, BOWLING, TANA, MERCER, LUKE, BACCHI, CYRUS, YARLETT, NIGEL, RANDOLPH, RYAN, PARHAM, ROBIN, REWERTS, CINDY, PLATNER, JACOB, DON, ROBERT
Publicado 2014

Assessment of a pretomanid analogue library for African trypanosomiasis: Hit-to-lead studies on 6-substituted 2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine 8-oxides

por Thompson, Andrew M., Marshall, Andrew J., Maes, Louis, Yarlett, Nigel, Bacchi, Cyrus J., Gaukel, Eric, Wring, Stephen A., Launay, Delphine, Braillard, Stephanie, Chatelain, Eric, Mowbray, Charles E., Denny, William A.
Publicado 2018

Mitochondrial Glycolysis in a Major Lineage of Eukaryotes

por Río Bártulos, Carolina, Rogers, Matthew B, Williams, Tom A, Gentekaki, Eleni, Brinkmann, Henner, Cerff, Rüdiger, Liaud, Marie-Françoise, Hehl, Adrian B, Yarlett, Nigel R, Gruber, Ansgar, Kroth, Peter G, van der Giezen, Mark
Publicado 2018

P-Glycoprotein–Mediated Efflux Reduces the In Vivo Efficacy of a Therapeutic Targeting the Gastrointestinal Parasite Cryptosporidium

por Arnold, Samuel L M, Choi, Ryan, Hulverson, Matthew A, Whitman, Grant R, Mccloskey, Molly C, Dorr, Carlie S, Vidadala, Rama S R, Khatod, Mansi, Morada, Mary, Barrett, Lynn K, Maly, Dustin J, Yarlett, Nigel, Van Voorhis, Wesley C
Publicado 2019

SCYX-7158, an Orally-Active Benzoxaborole for the Treatment of Stage 2 Human African Trypanosomiasis

por Jacobs, Robert T., Nare, Bakela, Wring, Stephen A., Orr, Matthew D., Chen, Daitao, Sligar, Jessica M., Jenks, Matthew X., Noe, Robert A., Bowling, Tana S., Mercer, Luke T., Rewerts, Cindy, Gaukel, Eric, Owens, Jennifer, Parham, Robin, Randolph, Ryan, Beaudet, Beth, Bacchi, Cyrus J., Yarlett, Nigel, Plattner, Jacob J., Freund, Yvonne, Ding, Charles, Akama, Tsutomu, Zhang, Y.-K., Brun, Reto, Kaiser, Marcel, Scandale, Ivan, Don, Robert
Publicado 2011