Early TP53 Alterations Shape Gastric and Esophageal Cancer Development

por Sahgal, Pranshu, Huffman, Brandon M., Patil, Deepa T., Chatila, Walid K., Yaeger, Rona, Cleary, James M., Sethi, Nilay S.
Publicado 2021

Retained Mismatch Repair Protein Expression Occurs in Approximately 6% of Microsatellite Instability-High Cancers and is Associated with Missense Mutations in Mismatch Repair Genes...

por Hechtman, Jaclyn F., Rana, Satshil, Middha, Sumit, Stadler, Zsofia K., Latham, Alicia, Benayed, Ryma, Soslow, Robert, Ladanyi, Marc, Yaeger, Rona, Zehir, Ahmet, Shia, Jinru
Publicado 2019

PI3K pathway mutations are associated with longer time to local progression after radioembolization of colorectal liver metastases

por Ziv, Etay, Bergen, Michael, Yarmohammadi, Hooman, Boas, F. Ed, Petre, E. Nadia, Sofocleous, Constantinos T., Yaeger, Rona, Solit, David B., Solomon, Stephen B., Erinjeri, Joseph P.
Publicado 2017

Recurrent, truncating SOX9 mutations are associated with SOX9 overexpression, KRAS mutation, and TP53 wild type status in colorectal carcinoma

por Javier, Breanna M., Yaeger, Rona, Wang, Lu, Sanchez-Vega, Francisco, Zehir, Ahmet, Middha, Sumit, Sadowska, Justyna, Vakiani, Efsevia, Shia, Jinru, Klimstra, David, Ladanyi, Marc, Iacobuzio-Donahue, Christine A., Hechtman, Jaclyn F.
Publicado 2016

Rare BRAF mutations in pancreatic neuroendocrine tumors may predict response to RAF and MEK inhibition

por Allen, Amy, Qin, Alice Can Ran, Raj, Nitya, Wang, Jiawan, Uddin, Sharmeen, Yao, Zhan, Tang, Laura, Meyers, Paul A., Taylor, Barry S., Berger, Michael F., Yaeger, Rona, Reidy-Lagunes, Diane, Pratilas, Christine A.
Publicado 2019

Chromothripsis drives the evolution of gene amplification in cancer

por Shoshani, Ofer, Brunner, Simon F., Yaeger, Rona, Ly, Peter, Nechemia-Arbely, Yael, Kim, Dong Hyun, Fang, Rongxin, Castillon, Guillaume A., Yu, Miao, Li, Julia S.Z., Sun, Ying, Ellisman, Mark H., Ren, Bing, Campbell, Peter J., Cleveland, Don W.
Publicado 2020

Quantitative assessment of tumor-infiltrating lymphocytes in mismatch repair proficient colon cancer

por Jimenez-Rodriguez, Rosa M., Patil, Sujata, Keshinro, Ajaratu, Shia, Jinru, Vakiani, Efsevia, Stadler, Zsofia, Segal, Neil H., Yaeger, Rona, Konishi, Tsuyoshi, Shimada, Yoshifumi, Widmar, Maria, Wei, Iris, Pappou, Emmanouil, Smith, J. Joshua, Nash, Garrett, Paty, Philip, Garcia-Aguilar, Julio, Weiser, Martin R.
Publicado 2020

Binimetinib, Encorafenib, and Cetuximab Triplet Therapy for Patients With BRAF V600E–Mutant Metastatic Colorectal Cancer: Safety Lead-In Results From the Phase III BEACON Colorecta...

por Van Cutsem, Eric, Huijberts, Sanne, Grothey, Axel, Yaeger, Rona, Cuyle, Pieter-Jan, Elez, Elena, Fakih, Marwan, Montagut, Clara, Peeters, Marc, Yoshino, Takayuki, Wasan, Harpreet, Desai, Jayesh, Ciardiello, Fortunato, Gollerkeri, Ashwin, Christy-Bittel, Janna, Maharry, Kati, Sandor, Victor, Schellens, Jan H.M., Kopetz, Scott, Tabernero, Josep
Publicado 2019

Encorafenib Plus Cetuximab as a New Standard of Care for Previously Treated BRAF V600E–Mutant Metastatic Colorectal Cancer: Updated Survival Results and Subgroup Analyses from the...

por Tabernero, Josep, Grothey, Axel, Van Cutsem, Eric, Yaeger, Rona, Wasan, Harpreet, Yoshino, Takayuki, Desai, Jayesh, Ciardiello, Fortunato, Loupakis, Fotios, Hong, Yong Sang, Steeghs, Neeltje, Guren, Tormod Kyrre, Arkenau, Hendrik-Tobias, Garcia-Alfonso, Pilar, Elez, Elena, Gollerkeri, Ashwin, Maharry, Kati, Christy-Bittel, Janna, Kopetz, Scott
Publicado 2021

Different hotspot p53 mutants exert distinct phenotypes and predict outcome of colorectal cancer patients

por Hassin, Ori, Nataraj, Nishanth Belugali, Shreberk-Shaked, Michal, Aylon, Yael, Yaeger, Rona, Fontemaggi, Giulia, Mukherjee, Saptaparna, Maddalena, Martino, Avioz, Adi, Iancu, Ortal, Mallel, Giuseppe, Gershoni, Anat, Grosheva, Inna, Feldmesser, Ester, Ben-Dor, Shifra, Golani, Ofra, Hendel, Ayal, Blandino, Giovanni, Kelsen, David, Yarden, Yosef, Oren, Moshe
Publicado 2022

RAF inhibitor PLX8394 selectively disrupts BRAF-dimers and RAS-independent BRAF mutant-driven signaling

por Yao, Zhan, Gao, Yijun, Su, Wenjing, Yaeger, Rona, Tao, Jessica, Na, Na, Zhang, Ying, Zhang, Chao, Rymar, Andrey, Tao, Anthony, Timaul, Neilawattie M., Mcgriskin, Rory, Outmezguine, Nathaniel A., Zhao, HuiYong, Chang, Qing, Qeriqi, Besnik, Barbacid, Mariano, de Stanchina, Elisa, Hyman, David M, Bollag, Gideon, Rosen, Neal
Publicado 2018

Heat Shock Factor 1-dependent extracellular matrix remodeling mediates the transition from chronic intestinal inflammation to colon cancer

por Levi-Galibov, Oshrat, Lavon, Hagar, Wassermann-Dozorets, Rina, Pevsner-Fischer, Meirav, Mayer, Shimrit, Wershof, Esther, Stein, Yaniv, Brown, Lauren E., Zhang, Wenhan, Friedman, Gil, Nevo, Reinat, Golani, Ofra, Katz, Lior H., Yaeger, Rona, Laish, Ido, Porco, John A., Sahai, Erik, Shouval, Dror S., Kelsen, David, Scherz-Shouval, Ruth
Publicado 2020

Contemporary Validation of a Nomogram Predicting Colon Cancer Recurrence, Revealing All-Stage Improved Outcomes

por Konishi, Tsuyoshi, Shimada, Yoshifumi, Hsu, Meier, Wei, Iris H, Pappou, Emmanouil, Smith, J Joshua, Nash, Garrett M, Guillem, José G, Paty, Philip B, Garcia-Aguilar, Julio, Cercek, Andrea, Yaeger, Rona, Stadler, Zsofia K, Segal, Neil H, Varghese, Anna, Saltz, Leonard B, Shia, Jinru, Vakiani, Efsevia, Gönen, Mithat, Weiser, Martin R
Publicado 2019

Genomic stratification beyond Ras/B‐Raf in colorectal liver metastasis patients treated with hepatic arterial infusion

por Smith, J. Joshua, Chatila, Walid K., Sanchez‐Vega, Francisco, Datta, Jashodeep, Connell, Louise C., Szeglin, Bryan C., Basunia, Azfar, Boucher, Taryn M., Hauser, Haley, Wasserman, Isaac, Wu, Chao, Cercek, Andrea, Hechtman, Jaclyn F., Madden, Chris, Jarnagin, William R., Garcia‐Aguilar, Julio, D'Angelica, Michael I., Yaeger, Rona, Schultz, Nikolaus, Kemeny, Nancy E.
Publicado 2019

Comparative sequencing analysis reveals high genomic concordance between matched primary and metastatic colorectal cancer lesions

por Brannon, A Rose, Vakiani, Efsevia, Sylvester, Brooke E, Scott, Sasinya N, McDermott, Gregory, Shah, Ronak H, Kania, Krishan, Viale, Agnes, Oschwald, Dayna M, Vacic, Vladimir, Emde, Anne-Katrin, Cercek, Andrea, Yaeger, Rona, Kemeny, Nancy E, Saltz, Leonard B, Shia, Jinru, D’Angelica, Michael I, Weiser, Martin R, Solit, David B, Berger, Michael F
Publicado 2014

Hematopoietic-specific heterozygous loss of Dnmt3a exacerbates colitis-associated colon cancer

por Feng, Yang, Yuan, Qingchen, Newsome, Rachel C., Robinson, Troy, Bowman, Robert L., Zuniga, Ashley N., Hall, Kendra N., Bernsten, Cassandra M., Shabashvili, Daniil E., Krajcik, Kathryn I., Gunaratne, Chamara, Zaroogian, Zachary J., Venugopal, Kartika, Casellas Roman, Heidi L., Levine, Ross L., Chatila, Walid K., Yaeger, Rona, Riva, Alberto, Jobin, Christian, Kopinke, Daniel, Avram, Dorina, Guryanova, Olga A.
Publicado 2023

Clinical Importance of Clonal Hematopoiesis in Metastatic Gastrointestinal Tract Cancers

por Diplas, Bill H., Ptashkin, Ryan, Chou, Joanne F., Sabwa, Shalom, Foote, Michael B., Rousseau, Benoit, Argilés, Guillem, White, James Robert, Stewart, Caitlin M., Bolton, Kelly, Chalasani, Sree B., Desai, Avni M., Goldberg, Zoe, Gu, Ping, Li, Jia, Shcherba, Marina, Zervoudakis, Alice, Cercek, Andrea, Yaeger, Rona, Segal, Neil H., Ilson, David H., Ku, Geoffrey Y., Zehir, Ahmet, Capanu, Marinela, Janjigian, Yelena Y., Diaz, Luis A., Maron, Steven B.
Publicado 2023

Resistance to TRK inhibition mediated by convergent MAP kinase pathway activation

por Cocco, Emiliano, Schram, Alison M, Kulick, Amanda, Misale, Sandra, Won, Helen H, Yaeger, Rona, Razavi, Pedram, Ptashkin, Ryan, Hechtman, Jaclyn F, Toska, Eneda, Cownie, James, Somwar, Romel, Shifman, Sophie, Mattar, Marissa, Selçuklu, S Duygu, Samoila, Aliaksandra, Guzman, Sean, Tuch, Brian B, Ebata, Kevin, de Stanchina, Elisa, Nagy, Rebecca J, Lanman, Richard B, Houck-Loomis, Brian, Patel, Juber A, Berger, Michael F, Ladanyi, Marc, Hyman, David M, Drilon, Alexander, Scaltriti, Maurizio
Publicado 2019

Integrated clinical and genomic analysis identifies driver events and molecular evolution of colitis-associated cancers

por Chatila, Walid K., Walch, Henry, Hechtman, Jaclyn F., Moyer, Sydney M., Sgambati, Valeria, Faleck, David M., Srivastava, Amitabh, Tang, Laura, Benhamida, Jamal, Ismailgeci, Dorina, Campos, Carl, Wu, Fan, Chang, Qing, Vakiani, Efsevia, de Stanchina, Elisa, Weiser, Martin R., Widmar, Maria, Yantiss, Rhonda K., Shah, Manish A., Bass, Adam J., Stadler, Zsofia K., Katz, Lior H., Mellinghoff, Ingo K., Sethi, Nilay S., Schultz, Nikolaus, Ganesh, Karuna, Kelsen, David, Yaeger, Rona
Publicado 2023

Survival After Induction Chemotherapy and Chemoradiation Versus Chemoradiation and Adjuvant Chemotherapy for Locally Advanced Rectal Cancer

por Kim, Jin K, Marco, Michael R, Roxburgh, Campbell S D, Chen, Chin-Tung, Cercek, Andrea, Strombom, Paul, Temple, Larissa K F, Nash, Garrett M, Guillem, Jose G, Paty, Philip B, Yaeger, Rona, Stadler, Zsofia K, Gonen, Mithat, Segal, Neil H, Reidy, Diane L, Varghese, Anna, Shia, Jinru, Vakiani, Efsevia, Wu, Abraham J, Romesser, Paul B, Crane, Christopher H, Gollub, Marc J, Saltz, Leonard, Smith, J Joshua, Weiser, Martin R, Patil, Sujata, Garcia-Aguilar, Julio
Publicado 2022