Molecular Dynamics-Based Design and Biophysical Evaluation of Thermostable Single-Chain Fv Antibody Mutants Derived from Pharmaceutical Antibodies

por Okazaki, Kyo, Kobashigawa, Yoshihiro, Morita, Hikari, Yamauchi, Soichiro, Fukuda, Natsuki, Liu, Chenjiang, Toyota, Yuya, Sato, Takashi, Morioka, Hiroshi
Publicado 2023

Cyclization of Single-Chain Fv Antibodies Markedly Suppressed Their Characteristic Aggregation Mediated by Inter-Chain VH-VL Interactions

por Yamauchi, Soichiro, Kobashigawa, Yoshihiro, Fukuda, Natsuki, Teramoto, Manaka, Toyota, Yuya, Liu, Chenjiang, Ikeguchi, Yuka, Sato, Takashi, Sato, Yuko, Kimura, Hiroshi, Masuda, Takeshi, Ohtsuki, Sumio, Noi, Kentaro, Ogura, Teru, Morioka, Hiroshi
Publicado 2019