The Nuclear Matrix Protein, NRP/B, Acts as a Transcriptional Repressor of E2F-mediated Transcriptional Activity

por Choi, Jina, Yang, Eun Sung, Cha, Kiweon, Whang, John, Choi, Woo-Jung, Avraham, Shalom, Kim, Tae-Aug
Publicado 2014

EV-D68 virus-like particle vaccines elicit cross-clade neutralizing antibodies that inhibit infection and block dissemination

por Krug, Peter W., Wang, Lingshu, Shi, Wei, Kong, Wing-Pui, Moss, Daniel L., Yang, Eun Sung, Fisher, Brian E., Morabito, Kaitlyn M., Mascola, John R., Kanekiyo, Masaru, Graham, Barney S., Ruckwardt, Tracy J.
Publicado 2023

Anti-viral efficacy of a next-generation CD4-binding site bNAb in SHIV-infected animals in the absence of anti-drug antibody responses

por Lovelace, Sarah E., Helmold Hait, Sabrina, Yang, Eun Sung, Fox, Madison L., Liu, Cuiping, Choe, Misook, Chen, Xuejun, McCarthy, Elizabeth, Todd, John-Paul, Woodward, Ruth A., Koup, Richard A., Mascola, John R., Pegu, Amarendra
Publicado 2022

Improvement of antibody functionality by structure-guided paratope engraftment

por Liu, Qingbo, Lai, Yen-Ting, Zhang, Peng, Louder, Mark K., Pegu, Amarendra, Rawi, Reda, Asokan, Mangaiarkarasi, Chen, Xuejun, Shen, Chen-Hsiang, Chuang, Gwo-Yu, Yang, Eun Sung, Miao, Huiyi, Wang, Yuge, Fauci, Anthony S., Kwong, Peter D., Mascola, John R., Lusso, Paolo
Publicado 2019

A matrix of structure-based designs yields improved VRC01-class antibodies for HIV-1 therapy and prevention

por Kwon, Young D., Asokan, Mangaiarkarasi, Gorman, Jason, Zhang, Baoshan, Liu, Qingbo, Louder, Mark K., Lin, Bob C., McKee, Krisha, Pegu, Amarendra, Verardi, Raffaello, Yang, Eun Sung, Program, VRC Production, Carlton, Kevin, Doria-Rose, Nicole A., Lusso, Paolo, Mascola, John R., Kwong, Peter D.
Publicado 2021

SARS-CoV-2 S2P spike ages through distinct states with altered immunogenicity

por Olia, Adam S., Tsybovsky, Yaroslav, Chen, Steven J., Liu, Cuiping, Nazzari, Alexandra F., Ou, Li, Wang, Lingshu, Kong, Wing-Pui, Leung, Kwan, Liu, Tracy, Stephens, Tyler, Teng, I-Ting, Wang, Shuishu, Yang, Eun Sung, Zhang, Baoshan, Zhang, Yi, Zhou, Tongqing, Mascola, John R., Kwong, Peter D.
Publicado 2021

Sequence-Signature Optimization Enables Improved Identification of Human HV6-1-Derived Class Antibodies That Neutralize Diverse Influenza A Viruses

por Chuang, Gwo-Yu, Shen, Chen-Hsiang, Cheung, Crystal Sao-Fong, Gorman, Jason, Creanga, Adrian, Joyce, M. Gordon, Leung, Kwanyee, Rawi, Reda, Wang, Lingshu, Yang, Eun Sung, Yang, Yongping, Zhang, Baoshan, Zhang, Yi, Kanekiyo, Masaru, Zhou, Tongqing, DeKosky, Brandon J., Graham, Barney S., Mascola, John R., Kwong, Peter D.
Publicado 2021

Improved pharmacokinetics of HIV-neutralizing VRC01-class antibodies achieved by reduction of net positive charge on variable domain

por Kwon, Young D., Pegu, Amarendra, Yang, Eun Sung, Zhang, Baoshan, Bender, Michael F., Asokan, Mangaiarkarasi, Liu, Qingbo, McKee, Krisha, Lin, Bob C., Liu, Tracy, Louder, Mark K., Rawi, Reda, Reveiz, Mateo, Schaub, Andrew J., Shen, Chen-Hsiang, Doria-Rose, Nicole A., Lusso, Paolo, Mascola, John R., Kwong, Peter D.
Publicado 2023

Removal of variable domain N-linked glycosylation as a means to improve the homogeneity of HIV-1 broadly neutralizing antibodies

por Chuang, Gwo-Yu, Asokan, Mangaiarkarasi, Ivleva, Vera B., Pegu, Amarendra, Yang, Eun Sung, Zhang, Baoshan, Chaudhuri, Rajoshi, Geng, Hui, Lin, Bob C., Louder, Mark K., McKee, Krisha, O’Dell, Sijy, Wang, Hairong, Zhou, Tongqing, Doria-Rose, Nicole A., Kueltzo, Lisa A., Lei, Q. Paula, Mascola, John R., Kwong, Peter D.
Publicado 2020

Self-assembling SARS-CoV-2 spike-HBsAg nanoparticles elicit potent and durable neutralizing antibody responses via genetic delivery

por Liu, Cuiping, Wang, Lingshu, Merriam, Jonah S., Shi, Wei, Yang, Eun Sung, Zhang, Yi, Chen, Man, Kong, Wing-Pui, Cheng, Cheng, Tsybovsky, Yaroslav, Stephens, Tyler, Verardi, Raffaello, Leung, Kwanyee, Stein, Cody, Olia, Adam S., Harris, Darcy R., Choe, Misook, Zhang, Baoshan, Graham, Barney S., Kwong, Peter D., Koup, Richard A., Pegu, Amarendra, Mascola, John R.
Publicado 2023

A Platform Incorporating Trimeric Antigens into Self-Assembling Nanoparticles Reveals SARS-CoV-2-Spike Nanoparticles to Elicit Substantially Higher Neutralizing Responses than Spik...

por Zhang, Baoshan, Chao, Cara W., Tsybovsky, Yaroslav, Abiona, Olubukola M., Hutchinson, Geoffrey B., Moliva, Juan I., Olia, Adam S., Pegu, Amarendra, Phung, Emily, Stewart-Jones, Guillaume, Verardi, Raffaello, Wang, Lingshu, Wang, Shuishu, Werner, Anne, Yang, Eun Sung, Yap, Christina, Zhou, Tongqing, Mascola, John R., Sullivan, Nancy J., Graham, Barney S., Corbett, Kizzmekia S., Kwong, Peter D.
Publicado 2020

Enhancing Anti-SARS-CoV-2 Neutralizing Immunity by Genetic Delivery of Enveloped Virus-like Particles Displaying SARS-CoV-2 Spikes

por Yang, Yongping, Kong, Wing-Pui, Liu, Cuiping, Ruckwardt, Tracy J., Tsybovsky, Yaroslav, Wang, Lingshu, Wang, Shuishu, Biner, Daniel W., Chen, Man, Liu, Tracy, Merriam, Jonah, Olia, Adam S., Ou, Li, Qiu, Qi, Shi, Wei, Stephens, Tyler, Yang, Eun Sung, Zhang, Baoshan, Zhang, Yi, Zhou, Qiong, Rawi, Reda, Koup, Richard A., Mascola, John R., Kwong, Peter D.
Publicado 2023

A platform incorporating trimeric antigens into self-assembling nanoparticles reveals SARS-CoV-2-spike nanoparticles to elicit substantially higher neutralizing responses than spik...

por Zhang, Baoshan, Chao, Cara W., Tsybovsky, Yaroslav, Abiona, Olubukola M., Hutchinson, Geoffrey B., Moliva, Juan I., Olia, Adam S., Pegu, Amarendra, Phung, Emily, Stewart-Jones, Guillaume B. E., Verardi, Raffaello, Wang, Lingshu, Wang, Shuishu, Werner, Anne, Yang, Eun Sung, Yap, Christina, Zhou, Tongqing, Mascola, John R., Sullivan, Nancy J., Graham, Barney S., Corbett, Kizzmekia S., Kwong, Peter D.
Publicado 2020

Vaccine-elicited murine antibody WS6 neutralizes diverse beta-coronaviruses by recognizing a helical stem supersite of vulnerability

por Shi, Wei, Wang, Lingshu, Zhou, Tongqing, Sastry, Mallika, Yang, Eun Sung, Zhang, Yi, Chen, Man, Chen, Xuejun, Choe, Misook, Creanga, Adrian, Leung, Kwan, Olia, Adam S., Pegu, Amarendra, Rawi, Reda, Shen, Chen-Hsiang, Stancofski, Erik-Stephane D., Talana, Chloe Adrienna, Teng, I-Ting, Wang, Shuishu, Corbett, Kizzmekia S., Tsybovsky, Yaroslav, Mascola, John R., Kwong, Peter D.
Publicado 2022

Single-dose bNAb cocktail or abbreviated ART post-exposure regimens achieve tight SHIV control without adaptive immunity

por Shapiro, Mariya B., Cheever, Tracy, Malherbe, Delphine C., Pandey, Shilpi, Reed, Jason, Yang, Eun Sung, Wang, Keyun, Pegu, Amarendra, Chen, Xuejun, Siess, Don, Burke, David, Henderson, Heidi, Lewinsohn, Rebecca, Fischer, Miranda, Stanton, Jeffrey J., Axthelm, Michael K., Kahl, Christoph, Park, Byung, Lewis, Anne D., Sacha, Jonah B., Mascola, John R., Hessell, Ann J., Haigwood, Nancy L.
Publicado 2020

Vaccine-elicited murine antibody WS6 neutralizes diverse beta-coronaviruses by recognizing a helical stem supersite of vulnerability

por Shi, Wei, Wang, Lingshu, Zhou, Tongqing, Sastry, Mallika, Yang, Eun Sung, Zhang, Yi, Chen, Man, Chen, Xuejun, Choe, Misook, Creanga, Adrian, Leung, Kwan, Olia, Adam S., Pegu, Amarendra, Rawi, Reda, Schön, Arne, Shen, Chen-Hsiang, Stancofski, Erik-Stephane D., Talana, Chloe Adrienna, Teng, I-Ting, Wang, Shuishu, Corbett, Kizzmekia S., Tsybovsky, Yaroslav, Mascola, John R., Kwong, Peter D.
Publicado 2022

Structural basis for potent antibody neutralization of SARS-CoV-2 variants including B.1.1.529

por Zhou, Tongqing, Wang, Lingshu, Misasi, John, Pegu, Amarendra, Zhang, Yi, Harris, Darcy R., Olia, Adam S., Talana, Chloe Adrienna, Yang, Eun Sung, Chen, Man, Choe, Misook, Shi, Wei, Teng, I-Ting, Creanga, Adrian, Jenkins, Claudia, Leung, Kwanyee, Liu, Tracy, Stancofski, Erik-Stephane D., Stephens, Tyler, Zhang, Baoshan, Tsybovsky, Yaroslav, Graham, Barney S., Mascola, John R., Sullivan, Nancy J., Kwong, Peter D.
Publicado 2022

Bispecific antibody CAP256.J3LS targets V2-apex and CD4-binding sites with high breadth and potency

por Zhang, Baoshan, Gorman, Jason, Kwon, Young D., Pegu, Amarendra, Chao, Cara W., Liu, Tracy, Asokan, Mangaiarkarasi, Bender, Michael F., Bylund, Tatsiana, Damron, Leland, Gollapudi, Deepika, Lei, Paula, Li, Yile, Liu, Cuiping, Louder, Mark K., McKee, Krisha, Olia, Adam S., Rawi, Reda, Schön, Arne, Wang, Shuishu, Yang, Eun Sung, Yang, Yongping, Carlton, Kevin, Doria-Rose, Nicole A., Shapiro, Lawrence, Seaman, Michael S., Mascola, John R., Kwong, Peter D.
Publicado 2023

Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses

por Kanekiyo, Masaru, Joyce, M. Gordon, Gillespie, Rebecca A., Gallagher, John R., Andrews, Sarah F., Yassine, Hadi M., Wheatley, Adam K., Fisher, Brian E., Ambrozak, David R., Creanga, Adrian, Leung, Kwanyee, Yang, Eun Sung, Boyoglu-Barnum, Seyhan, Georgiev, Ivelin S., Tsybovsky, Yaroslav, Prabhakaran, Madhu S., Andersen, Hanne, Kong, Wing-Pui, Baxa, Ulrich, Zephir, Kathryn L., Ledgerwood, Julie E., Koup, Richard A., Kwong, Peter D., Harris, Audray K., McDermott, Adrian B., Mascola, John R., Graham, Barney S.
Publicado 2019

Engineering of HIV-1 neutralizing antibody CAP256V2LS for manufacturability and improved half life

por Zhang, Baoshan, Gollapudi, Deepika, Gorman, Jason, O’Dell, Sijy, Damron, Leland F., McKee, Krisha, Asokan, Mangaiarkarasi, Yang, Eun Sung, Pegu, Amarendra, Lin, Bob C., Chao, Cara W., Chen, Xuejun, Gama, Lucio, Ivleva, Vera B., Law, William H., Liu, Cuiping, Louder, Mark K., Schmidt, Stephen D., Shen, Chen-Hsiang, Shi, Wei, Stein, Judith A., Seaman, Michael S., McDermott, Adrian B., Carlton, Kevin, Mascola, John R., Kwong, Peter D., Lei, Q. Paula, Doria-Rose, Nicole A.
Publicado 2022