Novel circuitry and molecular pathogenic mechanisms in Huntington's disease

por Yang, X William
Publicado 2012

Probing the stress and depression circuits with a disease gene

por Park, Chang Sin, Yang, X William
Publicado 2015

Genetically-directed Sparse Neuronal Labeling in BAC Transgenic Mice through Mononucleotide Repeat Frameshift

por Lu, Xiao-Hong, Yang, X. William
Publicado 2017

Pathological cell-cell interactions are necessary for striatal pathogenesis in a conditional mouse model of Huntington's disease

por Gu, Xiaofeng, André, Véronique M, Cepeda, Carlos, Li, Shi-Hua, Li, Xiao-Jiang, Levine, Michael S, Yang, X William
Publicado 2007

The N17 domain mitigates nuclear toxicity in a novel zebrafish Huntington’s disease model

por Veldman, Matthew B., Rios-Galdamez, Yesenia, Lu, Xiao-Hong, Gu, Xiaofeng, Qin, Wei, Li, Song, Yang, X. William, Lin, Shuo
Publicado 2015

MicroRNA signatures of endogenous Huntingtin CAG repeat expansion in mice

por Langfelder, Peter, Gao, Fuying, Wang, Nan, Howland, David, Kwak, Seung, Vogt, Thomas F., Aaronson, Jeffrey S., Rosinski, Jim, Coppola, Giovanni, Horvath, Steve, Yang, X. William
Publicado 2018

Striatal neurons directly converted from Huntington’s disease patient fibroblasts recapitulate age-associated disease phenotypes

por Victor, Matheus B., Richner, Michelle, Olsen, Hannah E., Lee, Seong Won, Monteys, Alejandro M., Ma, Chunyu, Huh, Christine J., Zhang, Bo, Davidson, Beverly L., Yang, X. William, Yoo, Andrew S.
Publicado 2018

Neuronal Targets of Mutant Huntingtin Genetic Reduction to Ameliorate Huntington’s Disease Pathogenesis in Mice

por Wang, Nan, Gray, Michelle, Lu, Xiao-Hong, Cantle, Jeffrey P., Holley, Sandra M., Greiner, Erin, Gu, Xiaofeng, Shirasaki, Dyna, Cepeda, Carlos, Li, Yuqing, Dong, Hongwei, Levine, Michael S., Yang, X. William
Publicado 2014

Clinical and Genetic Profiles in Chinese Patients with Huntington’s Disease: A Ten-year Multicenter Study in China

por Li, Hong-Lei, Li, Xiao-Yan, Dong, Yi, Zhang, Yan-Bin, Cheng, Hong-Rong, Gan, Shi-Rui, Liu, Zhi-Jun, Ni, Wang, Burgunder, Jean-Marc, Yang, X. William, Wu, Zhi-Ying
Publicado 2019

Precise segmentation of densely interweaving neuron clusters using G-Cut

por Li, Rui, Zhu, Muye, Li, Junning, Bienkowski, Michael S., Foster, Nicholas N., Xu, Hanpeng, Ard, Tyler, Bowman, Ian, Zhou, Changle, Veldman, Matthew B., Yang, X. William, Hintiryan, Houri, Zhang, Junsong, Dong, Hong-Wei
Publicado 2019

m(1)A in CAG repeat RNA binds to TDP-43 and induces neurodegeneration

por Sun, Yuxiang, Dai, Hui, Dai, Xiaoxia, Yin, Jiekai, Cui, Yuxiang, Liu, Xiaochuan, Gonzalez, Gwendolyn, Yuan, Jun, Tang, Feng, Wang, Nan, Perlegos, Alexandra E., Bonini, Nancy M., Yang, X. William, Gu, Weifeng, Wang, Yinsheng
Publicado 2023

Disease-related Huntingtin seeding activities in cerebrospinal fluids of Huntington’s disease patients

por Lee, C. Y. Daniel, Wang, Nan, Shen, Koning, Stricos, Matthew, Langfelder, Peter, Cheon, Kristina H., Cortés, Etty P., Vinters, Harry V., Vonsattel, Jean Paul, Wexler, Nancy S., Damoiseaux, Robert, Frydman, Judith, Yang, X. William
Publicado 2020

The mouse cortico-striatal projectome

por Hintiryan, Houri, Foster, Nicholas N., Bowman, Ian, Bay, Maxwell, Song, Monica Y., Gou, Lin, Yamashita, Seita, Bienkowski, Michael S., Zingg, Brian, Zhu, Muye, Yang, X. William, Shih, Jean C., Toga, Arthur W., Dong, Hong-Wei
Publicado 2016

N17 Modifies Mutant Huntingtin Nuclear Pathogenesis and Severity of Disease in HD BAC Transgenic Mice

por Gu, Xiaofeng, Cantle, Jeffrey P., Greiner, Erin R., Lee, C.Y. Daniel, Barth, Albert M., Gao, Fuying, Park, Chang Sin, Zhang, Zhiqiang, Sandoval-Miller, Susana, Zhang, Richard L., Diamond, Marc, Mody, Istvan, Coppola, Giovanni, Yang, X. William
Publicado 2015

Huntington's disease accelerates epigenetic aging of human brain and disrupts DNA methylation levels

por Horvath, Steve, Langfelder, Peter, Kwak, Seung, Aaronson, Jeff, Rosinski, Jim, Vogt, Thomas F., Eszes, Marika, Faull, Richard L.M., Curtis, Maurice A., Waldvogel, Henry J., Choi, Oi-Wa, Tung, Spencer, Vinters, Harry V., Coppola, Giovanni, Yang, X. William
Publicado 2016

Author Correction: Microglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in Huntington’s disease

por Wilton, Daniel K., Mastro, Kevin, Heller, Molly D., Gergits, Frederick W., Willing, Carly Rose, Fahey, Jaclyn B., Frouin, Arnaud, Daggett, Anthony, Gu, Xiaofeng, Kim, Yejin A., Faull, Richard L. M., Jayadev, Suman, Yednock, Ted, Yang, X. William, Stevens, Beth
Publicado 2023

Microglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in Huntington’s disease

por Wilton, Daniel K., Mastro, Kevin, Heller, Molly D., Gergits, Frederick W., Willing, Carly Rose, Fahey, Jaclyn B., Frouin, Arnaud, Daggett, Anthony, Gu, Xiaofeng, Kim, Yejin A., Faull, Richard L. M., Jayadev, Suman, Yednock, Ted, Yang, X. William, Stevens, Beth
Publicado 2023

Targeted Expression of Mu-Opioid Receptors in a Subset of Striatal Direct-Pathway Neurons Restores Opiate Reward

por Cui, Yijun, Ostlund, Sean B., James, Alex, Park, Chang Sin, Ge, Weihong, Roberts, Kristofer W., Mittal, Nitish, Murphy, Niall P., Cepeda, Carlos, Kieffer, Brigitte L., Levine, Michael S., Jentsch, J. David, Walwyn, Wendy M., Sun, Yi E., Evans, Christopher J., Maidment, Nigel T., Yang, X. William
Publicado 2014

Di-valent siRNA-mediated silencing of MSH3 blocks somatic repeat expansion in mouse models of Huntington’s disease

por O’Reilly, Daniel, Belgrad, Jillian, Ferguson, Chantal, Summers, Ashley, Sapp, Ellen, McHugh, Cassandra, Mathews, Ella, Boudi, Adel, Buchwald, Julianna, Ly, Socheata, Moreno, Dimas, Furgal, Raymond, Luu, Eric, Kennedy, Zachary, Hariharan, Vignesh, Monopoli, Kathryn, Yang, X. William, Carroll, Jeffery, DiFiglia, Marian, Aronin, Neil, Khvorova, Anastasia
Publicado 2023

Integrated genomics and proteomics to define huntingtin CAG length-dependent networks in HD Mice

por Langfelder, Peter, Cantle, Jeffrey P., Chatzopoulou, Doxa, Wang, Nan, Gao, Fuying, Al-Ramahi, Ismael, Lu, Xiao-Hong, Ramos, Eliana Marisa, El-Zein, Karla, Zhao, Yining, Deverasetty, Sandeep, Tebbe, Andreas, Schaab, Christoph, Lavery, Daniel J., Howland, David, Kwak, Seung, Botas, Juan, Aaronson, Jeffrey S., Rosinski, Jim, Coppola, Giovanni, Horvath, Steve, Yang, X. William
Publicado 2016