The role of c-Jun in controlling the EPAC1-dependent induction of the SOCS3 gene in HUVECs

por Wiejak, Jolanta, Dunlop, Julia, Yarwood, Stephen J.
Publicado 2014

Interaction with receptor for activated C-kinase 1 (RACK1) sensitizes the phosphodiesterase PDE4D5 towards hydrolysis of cAMP and activation by protein kinase C

por Bird, Rebecca J., Baillie, George S., Yarwood, Stephen J.
Publicado 2010

The cAMP sensors, EPAC1 and EPAC2, display distinct subcellular distributions despite sharing a common nuclear pore localisation signal

por Parnell, Euan, Smith, Brian O., Yarwood, Stephen J.
Publicado 2015

The future of EPAC-targeted therapies: agonism versus antagonism

por Parnell, Euan, Palmer, Timothy M., Yarwood, Stephen J.
Publicado 2015

Vascular smooth muscle cells enhance immune/vascular interplay in a 3-cell model of vascular inflammation

por Wiejak, Jolanta, Murphy, Fiona A., Maffia, Pasquale, Yarwood, Stephen J.
Publicado 2023

Flavanoids induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene and suppress IL-6-activated signal transducer and activator of transcription 3 (STAT3) activati...

por Wiejak, Jolanta, Dunlop, Julia, Mackay, Simon P., Yarwood, Stephen J.
Publicado 2013

Selective small-molecule EPAC activators

por Luchowska-Stańska, Urszula, Morgan, David, Yarwood, Stephen J., Barker, Graeme
Publicado 2019

Genome-Wide Mapping Defines a Role for C/EBPβ and c-Jun in Non-Canonical Cyclic AMP Signalling

por Wiejak, Jolanta, van Basten, Boy, Hamilton, Graham, Yarwood, Stephen J.
Publicado 2019

The novel exchange protein activated by cyclic AMP 1 (EPAC1) agonist, I942, regulates inflammatory gene expression in human umbilical vascular endothelial cells (HUVECs)

por Wiejak, Jolanta, van Basten, Boy, Luchowska-Stańska, Urszula, Hamilton, Graham, Yarwood, Stephen J.
Publicado 2019

Genomic analysis of the role of transcription factor C/EBPδ in the regulation of cell behaviour on nanometric grooves

por Wiejak, Jolanta, Tsimbouri, Penelope M., Herzyk, Pawel, Dalby, Matthew J., Hamilton, Graham, Yarwood, Stephen J.
Publicado 2013

The Potential of a Novel Class of EPAC-Selective Agonists to Combat Cardiovascular Inflammation

por Barker, Graeme, Parnell, Euan, van Basten, Boy, Buist, Hanna, Adams, David R., Yarwood, Stephen J.
Publicado 2017

Delineation of RAID1, the RACK1 interaction domain located within the unique N-terminal region of the cAMP-specific phosphodiesterase, PDE4D5

por Bolger, Graeme B, McCahill, Angela, Yarwood, Stephen J, Steele, Michael R, Warwicker, Jim, Houslay, Miles D
Publicado 2002

Protein interaction, cytotoxic, transcriptomic and proteomic responses to structurally distinct EPAC1 activators in HUVECs

por Wiejak, Jolanta, Luchowska-Stańska, Urszula, Wang, Pingyuan, Zhou, Jia, Maffia, Pasquale, Morgan, David, Barker, Graeme, Yarwood, Stephen J.
Publicado 2022

The protein kinase C inhibitor, Ro-31-7459, is a potent activator of ERK and JNK MAP kinases in HUVECs and yet inhibits cyclic AMP-stimulated SOCS-3 gene induction through inactiva...

por Wiejak, Jolanta, Dunlop, Julia, Stoyle, Chloe, Lappin, Gillian, McIlroy, Anna, Pediani, John D., Gao, Shan, Yarwood, Stephen J.
Publicado 2012

Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells

por Parnell, Euan, Koschinski, Andreas, Zaccolo, Manuela, Cameron, Ryan T., Baillie, George S., Baillie, Gemma L., Porter, Alison, McElroy, Stuart P., Yarwood, Stephen J.
Publicado 2015

Epac1 links prostaglandin E(2) to β-catenin-dependent transcription during epithelial-to-mesenchymal transition

por Jansen, Sepp R., Poppinga, Wilfred J., de Jager, Wim, Lezoualc'h, Frank, Cheng, Xiaodong, Wieland, Thomas, Yarwood, Stephen J., Gosens, Reinoud, Schmidt, Martina
Publicado 2016

Identification of a Novel, Small Molecule Partial Agonist for the Cyclic AMP Sensor, EPAC1

por Parnell, Euan, McElroy, Stuart P., Wiejak, Jolanta, Baillie, Gemma L., Porter, Alison, Adams, David R., Rehmann, Holger, Smith, Brian O., Yarwood, Stephen J.
Publicado 2017

Metformin suppresses adipogenesis through both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms

por Chen, Suet Ching, Brooks, Rebecca, Houskeeper, Jessica, Bremner, Shaun K., Dunlop, Julia, Viollet, Benoit, Logan, Pamela J., Salt, Ian P., Ahmed, S. Faisal, Yarwood, Stephen J.
Publicado 2017

Corrigendum to “Metformin suppresses adipogenesis through both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms” [Mol. Cell. Endocrinol. 440 15 January...

por Chen, S.C., Brooks, R., Houskeeper, J., Bremner, S.K., Dunlop, J., Viollet, B., Logan, P.J., Salt, I.P., Ahmed, S.F., Yarwood, S.J.
Publicado 2017

Mimitin – a novel cytokine-regulated mitochondrial protein

por Wegrzyn, Paulina, Yarwood, Stephen J, Fiegler, Nathalie, Bzowska, Monika, Koj, Aleksander, Mizgalska, Danuta, Malicki, Stanisław, Pajak, Magdalena, Kasza, Aneta, Kachamakova-Trojanowska, Neli, Bereta, Joanna, Jura, Jacek, Jura, Jolanta
Publicado 2009