C1q and the classical complement cascade in geographic atrophy secondary to age-related macular degeneration

por Yednock, Ted, Fong, Donald S., Lad, Eleonora M.
Publicado 2022

The Integrin α9β1 Mediates Adhesion to Activated Endothelial Cells and Transendothelial Neutrophil Migration through Interaction with Vascular Cell Adhesion Molecule-1

por Taooka, Yasuyuki, Chen, John, Yednock, Ted, Sheppard, Dean
Publicado 1999

Effects of an Alpha-4 Integrin Inhibitor on Restenosis in a New Porcine Model Combining Endothelial Denudation and Stent Placement

por Braun, Anne, Dofiles, Lilibeth, Rousselle, Serge, Guerrero, Luis, Gunther, Jane, Yednock, Ted, Stricker-Krongrad, Alain, Messersmith, Elizabeth
Publicado 2010

Subretinal macrophages produce classical complement activator C1q leading to the progression of focal retinal degeneration

por Jiao, Haihan, Rutar, Matt, Fernando, Nilisha, Yednock, Ted, Sankaranarayanan, Sethu, Aggio-Bruce, Riemke, Provis, Jan, Natoli, Riccardo
Publicado 2018

Safety and Target Engagement of Complement C1q Inhibitor ANX007 in Neurodegenerative Eye Disease: Results from Phase I Studies in Glaucoma

por Sun, Yang, Wirta, David, Murahashi, Wendy, Mathur, Vidhu, Sankaranarayanan, Sethu, Taylor, Lori K., Yednock, Ted, Fong, Donald S., Goldberg, Jeffrey L.
Publicado 2023

Differential Regulation of β(1) Integrins by Chemoattractants Regulates Neutrophil Migration through Fibrin

por Loike, John D., Cao, Long, Budhu, Sadna, Marcantonio, Eugene E., Khoury, Joseph El, Hoffman, Stanley, Yednock, Ted A., Silverstein, Samuel C.
Publicado 1999

The Classical Complement Pathway Mediates Microglia-Dependent Remodeling of Spinal Motor Circuits during Development and in SMA

por Vukojicic, Aleksandra, Delestrée, Nicolas, Fletcher, Emily V., Pagiazitis, John G., Sankaranarayanan, Sethu, Yednock, Ted A., Barres, Ben A., Mentis, George Z.
Publicado 2019

C1q-targeted inhibition of the classical complement pathway prevents injury in a novel mouse model of acute motor axonal neuropathy

por McGonigal, Rhona, Cunningham, Madeleine E., Yao, Denggao, Barrie, Jennifer A., Sankaranarayanan, Sethu, Fewou, Simon N., Furukawa, Koichi, Yednock, Ted A., Willison, Hugh J.
Publicado 2016

Pharmacokinetic and Target Engagement Measures of ANX007, an Anti-C1q Antibody Fragment, Following Intravitreal Administration in Nonhuman Primates

por Grover, Anita, Sankaranarayanan, Sethu, Mathur, Vidhu, Suri, Poojan, Qiu, Haiyan, Andrews-Zwilling, Yaisa, Mease, Kirsten, Taylor, Lori K., Cahir-McFarland, Ellen, Keswani, Sanjay, Yednock, Ted
Publicado 2023

Systems-Based Analyses of Brain Regions Functionally Impacted in Parkinson's Disease Reveals Underlying Causal Mechanisms

por Riley, Brigit E., Gardai, Shyra J., Emig-Agius, Dorothea, Bessarabova, Marina, Ivliev, Alexander E., Schüle, Birgit, Alexander, Jeff, Wallace, William, Halliday, Glenda M., Langston, J. William, Braxton, Scott, Yednock, Ted, Shaler, Thomas, Johnston, Jennifer A.
Publicado 2014

Author Correction: Microglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in Huntington’s disease

por Wilton, Daniel K., Mastro, Kevin, Heller, Molly D., Gergits, Frederick W., Willing, Carly Rose, Fahey, Jaclyn B., Frouin, Arnaud, Daggett, Anthony, Gu, Xiaofeng, Kim, Yejin A., Faull, Richard L. M., Jayadev, Suman, Yednock, Ted, Yang, X. William, Stevens, Beth
Publicado 2023

Microglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in Huntington’s disease

por Wilton, Daniel K., Mastro, Kevin, Heller, Molly D., Gergits, Frederick W., Willing, Carly Rose, Fahey, Jaclyn B., Frouin, Arnaud, Daggett, Anthony, Gu, Xiaofeng, Kim, Yejin A., Faull, Richard L. M., Jayadev, Suman, Yednock, Ted, Yang, X. William, Stevens, Beth
Publicado 2023

Laminin-411 Is a Vascular Ligand for MCAM and Facilitates TH17 Cell Entry into the CNS

por Flanagan, Ken, Fitzgerald, Kent, Baker, Jeanne, Regnstrom, Karin, Gardai, Shyra, Bard, Frederique, Mocci, Simonetta, Seto, Pui, You, Monica, Larochelle, Catherine, Prat, Alexandre, Chow, Samuel, Li, Lauri, Vandevert, Chris, Zago, Wagner, Lorenzana, Carlos, Nishioka, Christopher, Hoffman, Jennifer, Botelho, Raquel, Willits, Christopher, Tanaka, Kevin, Johnston, Jennifer, Yednock, Ted
Publicado 2012

Elevated Alpha-Synuclein Impairs Innate Immune Cell Function and Provides a Potential Peripheral Biomarker for Parkinson's Disease

por Gardai, Shyra J., Mao, Wenxian, Schüle, Birgitt, Babcock, Michael, Schoebel, Sue, Lorenzana, Carlos, Alexander, Jeff, Kim, Sam, Glick, Heather, Hilton, Kathryn, Fitzgerald, J. Kent, Buttini, Manuel, Chiou, San-San, McConlogue, Lisa, Anderson, John P., Schenk, Dale B., Bard, Frederique, Langston, J. William, Yednock, Ted, Johnston, Jennifer A.
Publicado 2013

Polo-like Kinase 2 (PLK2) Phosphorylates α-Synuclein at Serine 129 in Central Nervous System

por Inglis, Kelly J., Chereau, David, Brigham, Elizabeth F., Chiou, San-San, Schöbel, Susanne, Frigon, Normand L., Yu, Mei, Caccavello, Russell J., Nelson, Seth, Motter, Ruth, Wright, Sarah, Chian, David, Santiago, Pamela, Soriano, Ferdie, Ramos, Carla, Powell, Kyle, Goldstein, Jason M., Babcock, Michael, Yednock, Ted, Bard, Frederique, Basi, Guriqbal S., Sham, Hing, Chilcote, Tamie J., McConlogue, Lisa, Griswold-Prenner, Irene, Anderson, John P.
Publicado 2009

Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein by Small Molecules as a Potential Therapeutic Strategy for Parkinson’s Disease

por Tóth, Gergely, Gardai, Shyra J., Zago, Wagner, Bertoncini, Carlos W., Cremades, Nunilo, Roy, Susan L., Tambe, Mitali A., Rochet, Jean-Christophe, Galvagnion, Celine, Skibinski, Gaia, Finkbeiner, Steven, Bova, Michael, Regnstrom, Karin, Chiou, San-San, Johnston, Jennifer, Callaway, Kari, Anderson, John P., Jobling, Michael F., Buell, Alexander K., Yednock, Ted A., Knowles, Tuomas P. J., Vendruscolo, Michele, Christodoulou, John, Dobson, Christopher M., Schenk, Dale, McConlogue, Lisa
Publicado 2014

Novel Small Molecules Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein Protect Against Diverse α-Synuclein Mediated Dysfunctions

por Tóth, Gergely, Neumann, Thomas, Berthet, Amandine, Masliah, Eliezer, Spencer, Brian, Tao, Jiahui, Jobling, Michael F., Gardai, Shyra J., Bertoncini, Carlos W., Cremades, Nunilo, Bova, Michael, Ballaron, Stephen, Chen, Xiao-Hua, Mao, Wenxian, Nguyen, Phuong, Tabios, Mariano C., Tambe, Mitali A., Rochet, Jean-Christophe, Junker, Hans-Dieter, Schwizer, Daniel, Sekul, Renate, Ott, Inge, Anderson, John P., Szoke, Balazs, Hoffman, Wherly, Christodoulou, John, Yednock, Ted, Agard, David A., Schenk, Dale, McConlogue, Lisa
Publicado 2019