Mitochondria-derived peptides in aging and healthspan

por Miller, Brendan, Kim, Su-Jeong, Kumagai, Hiroshi, Yen, Kelvin, Cohen, Pinchas
Publicado 2022

GRSF1 is an age-related regulator of senescence

por Kim, Su-Jeong, Chun, Maria, Wan, Junxiang, Lee, Changhan, Yen, Kelvin, Cohen, Pinchas
Publicado 2019

MITOCHONDRIAL DNA VARIANT C2639T IS AN APOE4 RESILIENCE FACTOR

por Miller, Brendan, Kim, Su Jeong, Wan, Junxiang, Mehta, Hemal H, Yen, Kelvin, Cohen, Pinchas
Publicado 2019

A Comparative Study of Fat Storage Quantitation in Nematode Caenorhabditis elegans Using Label and Label-Free Methods

por Yen, Kelvin, Le, Thuc T., Bansal, Ankita, Narasimhan, Sri Devi, Cheng, Ji-Xin, Tissenbaum, Heidi A.
Publicado 2010

PDP-1 Links the TGF-β and IIS Pathways to Regulate Longevity, Development, and Metabolism

por Narasimhan, Sri Devi, Yen, Kelvin, Bansal, Ankita, Kwon, Eun-Soo, Padmanabhan, Srivatsan, Tissenbaum, Heidi A.
Publicado 2011

Novel Insights into Mitochondrial DNA: Mitochondrial Microproteins and mtDNA Variants Modulate Athletic Performance and Age-Related Diseases

por Kumagai, Hiroshi, Miller, Brendan, Kim, Su-Jeong, Leelaprachakul, Naphada, Kikuchi, Naoki, Yen, Kelvin, Cohen, Pinchas
Publicado 2023

FDA-Approved Drugs that Protect Mammalian Neurons from Glucose Toxicity Slow Aging Dependent on Cbp and Protect Against Proteotoxicity

por Lublin, Alex, Isoda, Fumiko, Patel, Harshil, Yen, Kelvin, Nguyen, Linda, Hajje, Daher, Schwartz, Marc, Mobbs, Charles
Publicado 2011

The mitochondrial-derived peptide humanin activates the ERK1/2, AKT, and STAT3 signaling pathways and has age-dependent signaling differences in the hippocampus

por Kim, Su-Jeong, Guerrero, Noel, Wassef, Gabriella, Xiao, Jialin, Mehta, Hemal H., Cohen, Pinchas, Yen, Kelvin
Publicado 2016

Metabolomic profile of diet-induced obesity mice in response to humanin and small humanin-like peptide 2 treatment

por Mehta, Hemal H., Xiao, Jialin, Ramirez, Ricardo, Miller, Brendan, Kim, Su-Jeong, Cohen, Pinchas, Yen, Kelvin
Publicado 2019

Role of CBP and SATB-1 in Aging, Dietary Restriction, and Insulin-Like Signaling

por Zhang, Minhua, Poplawski, Michal, Yen, Kelvin, Cheng, Hui, Bloss, Erik, Zhu, Xiao, Patel, Harshil, Mobbs, Charles V.
Publicado 2009

The Mitochondrial-Derived Peptides, HumaninS14G and Small Humanin-like Peptide 2, Exhibit Chaperone-like Activity

por Okada, Alan K., Teranishi, Kazuki, Lobo, Fleur, Isas, J. Mario, Xiao, Jialin, Yen, Kelvin, Cohen, Pinchas, Langen, Ralf
Publicado 2017

Mito-Omics and immune function: Applying novel mitochondrial omic techniques to the context of the aging immune system

por Silverstein, Ana R., Flores, Melanie K., Miller, Brendan, Kim, Su-Jeong, Yen, Kelvin, Mehta, Hemal H., Cohen, Pinchas
Publicado 2020

IGF-I regulates the age-dependent signaling peptide humanin

por Lee, Changhan, Wan, Junxiang, Miyazaki, Brian, Fang, Yimin, Guevara-Aguirre, Jaime, Yen, Kelvin, Longo, Valter, Bartke, Andrzej, Cohen, Pinchas
Publicado 2014

The mitochondrial‐derived peptide MOTS‐c is a regulator of plasma metabolites and enhances insulin sensitivity

por Kim, Su‐Jeong, Miller, Brendan, Mehta, Hemal H., Xiao, Jialin, Wan, Junxiang, Arpawong, Thalida E., Yen, Kelvin, Cohen, Pinchas
Publicado 2019

Host mitochondrial transcriptome response to SARS-CoV-2 in multiple cell models and clinical samples

por Miller, Brendan, Silverstein, Ana, Flores, Melanie, Cao, Kevin, Kumagai, Hiroshi, Mehta, Hemal H., Yen, Kelvin, Kim, Su- Jeong, Cohen, Pinchas
Publicado 2021

The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction

por Sreekumar, Parameswaran G., Ishikawa, Keijiro, Spee, Chris, Mehta, Hemal H., Wan, Junxiang, Yen, Kelvin, Cohen, Pinchas, Kannan, Ram, Hinton, David R.
Publicado 2016

Comparing the Utility of Mitochondrial and Nuclear DNA to Adjust for Genetic Ancestry in Association Studies

por Miller, Brendan, Arpawong, Thalida E., Jiao, Henry, Kim, Su-Jeong, Yen, Kelvin, Mehta, Hemal H., Wan, Junxiang, Carpten, John C., Cohen, Pinchas
Publicado 2019

A Mitochondrial Genome-Wide Association Study of Cataract in a Latino Population

por Miller, Brendan, Torres, Mina, Jiang, Xuejuan, McKean-Cowdin, Roberta, Nousome, Darryl, Kim, Su-Jeong, Mehta, Hemal H., Yen, Kelvin, Cohen, Pinchas, Varma, Rohit
Publicado 2020

Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers

por Cobb, Laura J., Lee, Changhan, Xiao, Jialin, Yen, Kelvin, Wong, Richard G., Nakamura, Hiromi K., Mehta, Hemal H., Gao, Qinglei, Ashur, Carmel, Huffman, Derek M., Wan, Junxiang, Muzumdar, Radhika, Barzilai, Nir, Cohen, Pinchas
Publicado 2016

Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans

por Yen, Kelvin, Wan, Junxiang, Mehta, Hemal H., Miller, Brendan, Christensen, Amy, Levine, Morgan E., Salomon, Matthew P., Brandhorst, Sebastian, Xiao, Jialin, Kim, Su-Jeong, Navarrete, Gerardo, Campo, Daniel, Harry, G. Jean, Longo, Valter, Pike, Christian J., Mack, Wendy J., Hodis, Howard N., Crimmins, Eileen M., Cohen, Pinchas
Publicado 2018