PBPK modeling of ivermectin—Considerations for the purpose of developing alternative routes to optimize its safety profile

por Rowland Yeo, Karen, Wesche, David
Publicado 2023

Physiologically‐Based Pharmacokinetic Models as Enablers of Precision Dosing in Drug Development: Pivotal Role of the Human Mass Balance Study

por Rowland Yeo, Karen, Venkatakrishnan, Karthik
Publicado 2020

Addressing drug safety of maternal therapy during breastfeeding using physiologically‐based pharmacokinetic modeling

por Pan, Xian, Rowland Yeo, Karen
Publicado 2022

An Integrated Approach for Assessing the Impact of Renal Impairment on Pharmacokinetics of Drugs in Development: Pivotal Role of PBPK Modelling

por Rowland Yeo, Karen, Gil Berglund, Eva
Publicado 2021

Correction to: Development of Guanfacine Extended-Release Dosing Strategies in Children and Adolescents with ADHD Using a Physiologically Based Pharmacokinetic Model to Predict Dru...

por Li, Aiqun, Yeo, Karen, Welty, Devin, Rong, Haojing
Publicado 2017

Development of Guanfacine Extended-Release Dosing Strategies in Children and Adolescents with ADHD Using a Physiologically Based Pharmacokinetic Model to Predict Drug–Drug Interact...

por Li, Aiqun, Yeo, Karen, Welty, Devin, Rong, Haojing
Publicado 2017

Physiologically‐Based Pharmacokinetic Modeling for Predicting Drug Interactions of a Combination of Olanzapine and Samidorphan

por Sun, Lei, von Moltke, Lisa, Rowland Yeo, Karen
Publicado 2020

Application of Physiologically Based Pharmacokinetic Modeling to Predict the Effect of Renal Impairment on the Pharmacokinetics of Olanzapine and Samidorphan Given in Combination

por Sun, Lei, von Moltke, Lisa, Rowland Yeo, Karen
Publicado 2020

Increasing application of pediatric physiologically based pharmacokinetic models across academic and industry organizations

por Johnson, Trevor N., Small, Ben G., Rowland Yeo, Karen
Publicado 2022

Using physiologically‐based pharmacokinetic modeling for predicting the effects of hepatic impairment on the pharmacokinetics of olanzapine and samidorphan given as a combination t...

por Sun, Lei, Barter, Zoe, von Moltke, Lisa, Rowland Yeo, Karen
Publicado 2021

Physiologically Based Pharmacokinetic Modelling to Predict Imatinib Exposures in Cancer Patients with Renal Dysfunction: A Case Study

por Rowland Yeo, Karen, Hatley, Oliver, Small, Ben G., Johnson, Trevor N.
Publicado 2023

A best practice framework for applying physiologically‐based pharmacokinetic modeling to pediatric drug development

por Johnson, Trevor N., Small, Ben G., Berglund, Eva Gil, Rowland Yeo, Karen
Publicado 2021

Risk–Benefit Assessment of Ethinylestradiol Using a Physiologically Based Pharmacokinetic Modeling Approach

por Ezuruike, Udoamaka, Humphries, Helen, Dickins, Maurice, Neuhoff, Sibylle, Gardner, Iain, Rowland Yeo, Karen
Publicado 2018

Impact of Disease on Plasma and Lung Exposure of Chloroquine, Hydroxychloroquine and Azithromycin: Application of PBPK Modeling

por Rowland Yeo, Karen, Zhang, Mian, Pan, Xian, Ban Ke, Alice, Jones, Hannah M., Wesche, David, Almond, Lisa M.
Publicado 2020

Prediction of CYP‐mediated DDIs involving inhibition: Approaches to address the requirements for system qualification of the Simcyp Simulator

por Kilford, Peter J., Chen, Kuan‐Fu, Crewe, Kim, Gardner, Iain, Hatley, Oliver, Ke, Alice Ban, Neuhoff, Sibylle, Zhang, Mian, Rowland Yeo, Karen
Publicado 2022

CPT: Pharmacometrics & Systems Pharmacology – Inception, Maturation, and Future Vision

por Rowland Yeo, Karen, Hennig, Stefanie, Krishnaswami, Sriram, Strydom, Natasha, Ayyar, Vivaswath S., French, Jonathan, Sinha, Vikram, Sobie, Eric, Zhao, Ping, Friberg, Lena E., Mentré, France
Publicado 2021

Prediction of Drug-Drug Interactions Arising from CYP3A induction Using a Physiologically Based Dynamic Model

por Almond, Lisa M., Mukadam, Sophie, Gardner, Iain, Okialda, Krystle, Wong, Susan, Hatley, Oliver, Tay, Suzanne, Rowland-Yeo, Karen, Jamei, Masoud, Rostami-Hodjegan, Amin, Kenny, Jane R.
Publicado 2016

Model‐Informed Drug Development for Anti‐Infectives: State of the Art and Future

por Rayner, Craig R., Smith, Patrick F., Andes, David, Andrews, Kayla, Derendorf, Hartmut, Friberg, Lena E., Hanna, Debra, Lepak, Alex, Mills, Edward, Polasek, Thomas M., Roberts, Jason A., Schuck, Virna, Shelton, Mark J., Wesche, David, Rowland‐Yeo, Karen
Publicado 2021

Effects of Strong CYP3A Inhibition and Induction on the Pharmacokinetics of Ixazomib, an Oral Proteasome Inhibitor: Results of Drug‐Drug Interaction Studies in Patients With Advanc...

por Gupta, Neeraj, Hanley, Michael J., Venkatakrishnan, Karthik, Bessudo, Alberto, Rasco, Drew W., Sharma, Sunil, O'Neil, Bert H., Wang, Bingxia, Liu, Guohui, Ke, Alice, Patel, Chirag, Rowland Yeo, Karen, Xia, Cindy, Zhang, Xiaoquan, Esseltine, Dixie‐Lee, Nemunaitis, John
Publicado 2017

Development and application of a PBPK modeling strategy to support antimalarial drug development

por Abla, Nada, Howgate, Eleanor, Rowland‐Yeo, Karen, Dickins, Maurice, Bergagnini‐Kolev, Mackenzie C., Chen, Kuan‐Fu, McFeely, Savannah, Bonner, Jennifer J., Santos, Laura G. A., Gobeau, Nathalie, Burt, Howard, Barter, Zoe, Jones, Hannah M., Wesche, David, Charman, Susan A., Möhrle, Jörg J., Burrows, Jeremy N., Almond, Lisa M.
Publicado 2023