Nonclinical safety evaluation of pabinafusp alfa, an anti-human transferrin receptor antibody and iduronate-2-sulfatase fusion protein, for the treatment of neuronopathic mucopolys...

por Yamamoto, Ryuji, Yoden, Eiji, Tanaka, Noboru, Kinoshita, Masafumi, Imakiire, Atsushi, Hirato, Tohru, Minami, Kohtaro
Publicado 2021

Clearance of heparan sulfate in the brain prevents neurodegeneration and neurocognitive impairment in MPS II mice

por Morimoto, Hideto, Kida, Sachiho, Yoden, Eiji, Kinoshita, Masafumi, Tanaka, Noboru, Yamamoto, Ryuji, Koshimura, Yuri, Takagi, Haruna, Takahashi, Kenichi, Hirato, Tohru, Minami, Kohtaro, Sonoda, Hiroyuki
Publicado 2021

A Blood-Brain-Barrier-Penetrating Anti-human Transferrin Receptor Antibody Fusion Protein for Neuronopathic Mucopolysaccharidosis II

por Sonoda, Hiroyuki, Morimoto, Hideto, Yoden, Eiji, Koshimura, Yuri, Kinoshita, Masafumi, Golovina, Galina, Takagi, Haruna, Yamamoto, Ryuji, Minami, Kohtaro, Mizoguchi, Akira, Tachibana, Katsuhiko, Hirato, Tohru, Takahashi, Kenichi
Publicado 2018

Transferrin Receptor-Targeted Iduronate-2-sulfatase Penetrates the Blood-Retinal Barrier and Improves Retinopathy in Mucopolysaccharidosis II Mice

por Imakiire, Atsushi, Morimoto, Hideto, Suzuki, Hidehiko, Masuda, Tomomi, Yoden, Eiji, Inoue, Asuka, Morioka, Hiroki, Konaka, Takashi, Mori, Ayaka, Shirasaka, Ryoji, Kato, Ryo, Hirato, Tohru, Sonoda, Hiroyuki, Minami, Kohtaro
Publicado 2023

Enzyme replacement with transferrin receptor-targeted α-L-iduronidase rescues brain pathology in mucopolysaccharidosis I mice

por Kida, Sachiho, Koshimura, Yuri, Yoden, Eiji, Yoshioka, Aya, Morimoto, Hideto, Imakiire, Atsushi, Tanaka, Noboru, Tanaka, Satowa, Mori, Ayaka, Ito, Jun, Inoue, Asuka, Yamamoto, Ryuji, Minami, Kohtaro, Hirato, Tohru, Takahashi, Kenichi, Sonoda, Hiroyuki
Publicado 2023