Altered Expression of Hepatic CYP1A Enzymes in Rat Hepatocarcinogenesis

por Degawa, Masakuni, Miura, Shin‐ichi, Yoshinari, Kouichi, Hashimoto, Yoshiyuki
Publicado 1995

Effect of health foods on cytochrome P450-mediated drug metabolism

por Sasaki, Takamitsu, Sato, Yu, Kumagai, Takeshi, Yoshinari, Kouichi, Nagata, Kiyoshi
Publicado 2017

Prediction Model of Aryl Hydrocarbon Receptor Activation by a Novel QSAR Approach, DeepSnap–Deep Learning

por Matsuzaka, Yasunari, Hosaka, Takuomi, Ogaito, Anna, Yoshinari, Kouichi, Uesawa, Yoshihiro
Publicado 2020

PPARα Induces the Expression of CAR That Works as a Negative Regulator of PPARα Functions in Mouse Livers

por Shizu, Ryota, Otsuka, Yuta, Ishii, Chizuru, Ezaki, Kanako, Yoshinari, Kouichi
Publicado 2023

Xenobiotic-Induced Hepatocyte Proliferation Associated with Constitutive Active/Androstane Receptor (CAR) or Peroxisome Proliferator-Activated Receptor α (PPARα) Is Enhanced by Pre...

por Shizu, Ryota, Benoki, Satoshi, Numakura, Yuki, Kodama, Susumu, Miyata, Masaaki, Yamazoe, Yasushi, Yoshinari, Kouichi
Publicado 2013

PXR Functionally Interacts with NF-κB and AP-1 to Downregulate the Inflammation-Induced Expression of Chemokine CXCL2 in Mice

por Okamura, Maya, Shizu, Ryota, Abe, Taiki, Kodama, Susumu, Hosaka, Takuomi, Sasaki, Takamitsu, Yoshinari, Kouichi
Publicado 2020

PXR Suppresses PPARα-Dependent HMGCS2 Gene Transcription by Inhibiting the Interaction between PPARα and PGC1α

por Shizu, Ryota, Ezaki, Kanako, Sato, Takumi, Sugawara, Ayaka, Hosaka, Takuomi, Sasaki, Takamitsu, Yoshinari, Kouichi
Publicado 2021

Identification of average molecular weight (AMW) as a useful chemical descriptor to discriminate liver injury-inducing drugs

por Shimizu, Yuki, Sasaki, Takamitsu, Takeshita, Jun-ichi, Watanabe, Michiko, Shizu, Ryota, Hosaka, Takuomi, Yoshinari, Kouichi
Publicado 2021

Screening for DAX1/EWS‐FLI1 functional inhibitors identified dihydroorotate dehydrogenase as a therapeutic target for Ewing's sarcoma

por Watanabe, Miwa, Kosaka, Hiromichi, Sugawara, Masamori, Maemoto, Michihiro, Ono, Yoko, Uemori, Takeshi, Shizu, Ryota, Yoshinari, Kouichi
Publicado 2023

Possible Involvement of the Upregulation of ΔNp63 Expression Mediated by HER2-Activated Aryl Hydrocarbon Receptor in Mammosphere Maintenance

por Kanno, Yuichiro, Saito, Nao, Yamashita, Naoya, Ota, Kazuki, Shizu, Ryota, Hosaka, Takuomi, Nemoto, Kiyomitsu, Yoshinari, Kouichi
Publicado 2022

Activation of PXR, CAR and PPARα by pyrethroid pesticides and the effect of metabolism by rat liver microsomes

por Fujino, Chieri, Watanabe, Yoko, Sanoh, Seigo, Nakajima, Hiroyuki, Uramaru, Naoto, Kojima, Hiroyuki, Yoshinari, Kouichi, Ohta, Shigeru, Kitamura, Shigeyuki
Publicado 2019

Helix 12 stabilization contributes to basal transcriptional activity of PXR

por Shizu, Ryota, Nishiguchi, Hikaru, Tashiro, Sarii, Sato, Takumi, Sugawara, Ayaka, Kanno, Yuichiro, Hosaka, Takuomi, Sasaki, Takamitsu, Yoshinari, Kouichi
Publicado 2021