Processing binding data using an open-source workflow

por Samuel, Errol L. G., Holmes, Secondra L., Young, Damian W.
Publicado 2021

Distinct Biological Network Properties between the Targets of Natural Products and Disease Genes

por Dančík, Vlado, Seiler, Kathleen Petri, Young, Damian W., Schreiber, Stuart L., Clemons, Paul A.
Publicado 2010

Examining multiple cellular pathways at once using multiplex hextuple luciferase assaying

por Sarrion-Perdigones, Alejandro, Chang, Lyra, Gonzalez, Yezabel, Gallego-Flores, Tatiana, Young, Damian W., Venken, Koen J. T.
Publicado 2019

Metabolism of JQ1, an inhibitor of bromodomain and extra terminal bromodomain proteins, in human and mouse liver microsomes

por Li, Feng, MacKenzie, Kevin R, Jain, Prashi, Santini, Conrad, Young, Damian W, Matzuk, Martin M
Publicado 2020

Homogeneous and Functional Group Tolerant Ring-Closing Metathesis for DNA-Encoded Chemical Libraries

por Monty, Olivier B. C., Nyshadham, Pranavanand, Bohren, Kurt M., Palaniappan, Murugesan, Matzuk, Martin M., Young, Damian W., Simmons, Nicholas
Publicado 2020

A Concise Synthetic Method for Constructing 3-Substituted Piperazine-2-Acetic Acid Esters from 1,2-Diamines

por Chamakuri, Srinivas, Tang, Sunny Ann, Tran, Kevin A., Guduru, Shiva Krishna Reddy, Bolin, Peter K., MacKenzie, Kevin R., Young, Damian W.
Publicado 2022

The roles of Cyp1a2 and Cyp2d in pharmacokinetic profiles of serotonin and norepinephrine reuptake inhibitor duloxetine and its metabolites in mice

por Qin, Xuan, Xie, Cen, Hakenjos, John M., MacKenzie, Kevin R., Boyd, Shelton R., Barzi, Mercedes, Bissig, Karl-Dimiter, Young, Damian W., Li, Feng
Publicado 2023

Identifying the Reactive Metabolites of Tyrosine Kinase Inhibitor Pexidartinib In Vitro Using LC–MS-Based Metabolomic Approaches

por Qin, Xuan, Wang, Yong, MacKenzie, Kevin R., Hakenjos, John M., Chen, Si, Khalil, Saleh M., Jung, Sung Yun, Young, Damian W., Guo, Lei, Li, Feng
Publicado 2023

SPA-STOCSY: an automated tool for identifying annotated and non-annotated metabolites in high-throughput NMR spectra

por Han, Xu, Wang, Wanli, Ma, Li-Hua, AI-Ramahi, Ismael, Botas, Juan, MacKenzie, Kevin, Allen, Genevera I, Young, Damian W, Liu, Zhandong, Maletic-Savatic, Mirjana
Publicado 2023

SPA-STOCSY: An Automated Tool for Identification of Annotated and Non-Annotated Metabolites in High-Throughput NMR Spectra

por Han, Xu, Wang, Wanli, Ma, Li-Hua, Al-Ramahi, Ismael, Botas, Juan, MacKenzie, Kevin, Allen, Genevera I., Young, Damian W., Liu, Zhandong, Maletic-Savatic, Mirjana
Publicado 2023

Gain-of-Signal Assays for Probing Inhibition of SARS-CoV-2 M(pro)/3CL(pro) in Living Cells

por Moghadasi, Seyed Arad, Esler, Morgan A., Otsuka, Yuka, Becker, Jordan T., Moraes, Sofia N., Anderson, Constance B., Chamakuri, Srinivas, Belica, Christopher, Wick, Chloe, Harki, Daniel A., Young, Damian W., Scampavia, Louis, Spicer, Timothy P., Shi, Ke, Aihara, Hideki, Brown, William L., Harris, Reuben S.
Publicado 2022

Discovery and characterization of bromodomain 2–specific inhibitors of BRDT

por Yu, Zhifeng, Ku, Angela F., Anglin, Justin L., Sharma, Rajesh, Ucisik, Melek Nihan, Faver, John C., Li, Feng, Nyshadham, Pranavanand, Simmons, Nicholas, Sharma, Kiran L., Nagarajan, Sureshbabu, Riehle, Kevin, Kaur, Gundeep, Sankaran, Banumathi, Storl-Desmond, Marta, Palmer, Stephen S., Young, Damian W., Kim, Choel, Matzuk, Martin M.
Publicado 2021

Discovery of small molecules targeting the tandem tudor domain of the epigenetic factor UHRF1 using fragment-based ligand discovery

por Chang, Lyra, Campbell, James, Raji, Idris O., Guduru, Shiva K. R., Kandel, Prasanna, Nguyen, Michelle, Liu, Steven, Tran, Kevin, Venugopal, Navneet K., Taylor, Bethany C., Holt, Matthew V., Young, Nicolas L., Samuel, Errol L. G., Jain, Prashi, Santini, Conrad, Sankaran, Banumathi, MacKenzie, Kevin R., Young, Damian W.
Publicado 2021

Discovery of potent BET bromodomain 1 stereoselective inhibitors using DNA-encoded chemical library selections

por Modukuri, Ram K., Yu, Zhifeng, Tan, Zhi, Ta, Hai Minh, Ucisik, Melek Nihan, Jin, Zhuang, Anglin, Justin L., Sharma, Kiran L., Nyshadham, Pranavanand, Li, Feng, Riehle, Kevin, Faver, John C., Duong, Kevin, Nagarajan, Sureshbabu, Simmons, Nicholas, Palmer, Stephen S., Teng, Mingxing, Young, Damian W., Yi, Joanna S., Kim, Choel, Matzuk, Martin M.
Publicado 2022

DNA-encoded chemical libraries yield non-covalent and non-peptidic SARS-CoV-2 main protease inhibitors

por Jimmidi, Ravikumar, Chamakuri, Srinivas, Lu, Shuo, Ucisik, Melek Nihan, Chen, Peng-Jen, Bohren, Kurt M., Moghadasi, Seyed Arad, Versteeg, Leroy, Nnabuife, Christina, Li, Jian-Yuan, Qin, Xuan, Chen, Ying-Chu, Faver, John C., Nyshadham, Pranavanand, Sharma, Kiran L., Sankaran, Banumathi, Judge, Allison, Yu, Zhifeng, Li, Feng, Pollet, Jeroen, Harris, Reuben S., Matzuk, Martin M., Palzkill, Timothy, Young, Damian W.
Publicado 2023

DNA-encoded chemistry technology yields expedient access to SARS-CoV-2 M(pro) inhibitors

por Chamakuri, Srinivas, Lu, Shuo, Ucisik, Melek Nihan, Bohren, Kurt M., Chen, Ying-Chu, Du, Huang-Chi, Faver, John C., Jimmidi, Ravikumar, Li, Feng, Li, Jian-Yuan, Nyshadham, Pranavanand, Palmer, Stephen S., Pollet, Jeroen, Qin, Xuan, Ronca, Shannon E., Sankaran, Banumathi, Sharma, Kiran L., Tan, Zhi, Versteeg, Leroy, Yu, Zhifeng, Matzuk, Martin M., Palzkill, Timothy, Young, Damian W.
Publicado 2021

Oleic acid is an endogenous ligand of TLX/NR2E1 that triggers hippocampal neurogenesis

por Kandel, Prasanna, Semerci, Fatih, Mishra, Rachana, Choi, William, Bajic, Aleksandar, Baluya, Dodge, Ma, LiHua, Chen, Kevin, Cao, Austin C., Phongmekhin, Tipwarin, Matinyan, Nick, Jiménez-Panizo, Alba, Chamakuri, Srinivas, Raji, Idris O., Chang, Lyra, Fuentes-Prior, Pablo, MacKenzie, Kevin R., Benn, Caroline L., Estébanez-Perpiñá, Eva, Venken, Koen, Moore, David D., Young, Damian W., Maletic-Savatic, Mirjana
Publicado 2022