The role of Alzheimer’s disease risk genes in endolysosomal pathways

por Szabo, Marcell P., Mishra, Swati, Knupp, Allison, Young, Jessica E.
Publicado 2022

Evaluation of a Selective Chemical Probe Validates That CK2 Mediates Neuroinflammation in a Human Induced Pluripotent Stem Cell-Derived Mircroglial Model

por Mishra, Swati, Kinoshita, Chizuru, Axtman, Alison D., Young, Jessica E.
Publicado 2022

Stabilizing the Retromer Complex in a Human Stem Cell Model of Alzheimer’s Disease Reduces TAU Phosphorylation Independently of Amyloid Precursor Protein

por Young, Jessica E., Fong, Lauren K., Frankowski, Harald, Petsko, Gregory A., Small, Scott A., Goldstein, Lawrence S.B.
Publicado 2018

Knock-Down of HDAC2 in Human Induced Pluripotent Stem Cell Derived Neurons Improves Neuronal Mitochondrial Dynamics, Neuronal Maturation and Reduces Amyloid Beta Peptides

por Frankowski, Harald, Yeboah, Fred, Berry, Bonnie J., Kinoshita, Chizuru, Lee, Michelle, Evitts, Kira, Davis, Joshua, Kinoshita, Yoshito, Morrison, Richard S., Young, Jessica E.
Publicado 2021

Prolonged culturing of iPSC-derived brain endothelial-like cells is associated with quiescence, downregulation of glycolysis, and resistance to disruption by an Alzheimer’s brain m...

por Williams, Lindsey M., Fujimoto, Takashi, Weaver, Riley R., Logsdon, Aric F., Evitts, Kira M., Young, Jessica E., Banks, William A., Erickson, Michelle A.
Publicado 2022

The Alzheimer’s gene SORL1 is a regulator of endosomal traffic and recycling in human neurons

por Mishra, Swati, Knupp, Allison, Szabo, Marcell P., Williams, Charles A., Kinoshita, Chizuru, Hailey, Dale W., Wang, Yuliang, Andersen, Olav M., Young, Jessica E.
Publicado 2022

A Rainbow Reporter Tracks Single Cells and Reveals Heterogeneous Cellular Dynamics among Pluripotent Stem Cells and Their Differentiated Derivatives

por El-Nachef, Danny, Shi, Kevin, Beussman, Kevin M., Martinez, Refugio, Regier, Mary C., Everett, Guy W., Murry, Charles E., Stevens, Kelly R., Young, Jessica E., Sniadecki, Nathan J., Davis, Jennifer
Publicado 2020

A familial missense variant in the Alzheimer’s Disease gene SORL1 impairs its maturation and endosomal sorting

por Fazeli, Elnaz, Child, Daniel D., Bucks, Stephanie A., Stovarsky, Miki, Edwards, Gabrielle, Rose, Shannon E., Yu, Chang-En, Latimer, Caitlin, Kitago, Yu, Bird, Thomas, Jayadev, Suman, Andersen, Olav M., Young, Jessica E.
Publicado 2023

Polyglutamine-expanded androgen receptor interferes with TFEB to elicit pathological autophagy defects in SBMA

por Cortes, Constanza J., Miranda, Helen C., Frankowski, Harald, Batlevi, Yakup, Young, Jessica E., Le, Amy, Ivanov, Nishi, Sopher, Bryce L., Carromeu, Cassiano, Muotri, Alysson R., Garden, Gwenn A., La Spada, Albert R.
Publicado 2014

Leptomeninges-Derived Induced Pluripotent Stem Cells and Directly Converted Neurons From Autopsy Cases With Varying Neuropathologic Backgrounds

por Rose, Shannon E, Frankowski, Harald, Knupp, Allison, Berry, Bonnie J, Martinez, Refugio, Dinh, Stephanie Q, Bruner, Lauren T, Willis, Sherry L, Crane, Paul K, Larson, Eric B, Grabowski, Thomas, Darvas, Martin, Keene, C Dirk, Young, Jessica E
Publicado 2018

Human microglia show unique transcriptional changes in Alzheimer’s disease

por Prater, Katherine E., Green, Kevin J., Mamde, Sainath, Sun, Wei, Cochoit, Alexandra, Smith, Carole L., Chiou, Kenneth L., Heath, Laura, Rose, Shannon E., Wiley, Jesse, Keene, C. Dirk, Kwon, Ronald Y., Snyder-Mackler, Noah, Blue, Elizabeth E., Logsdon, Benjamin, Young, Jessica E., Shojaie, Ali, Garden, Gwenn A., Jayadev, Suman
Publicado 2023

Expression of an alternatively spliced variant of SORL1 in neuronal dendrites is decreased in patients with Alzheimer’s disease

por Monti, Giulia, Kjolby, Mads, Jensen, Anne Mette G., Allen, Mariet, Reiche, Juliane, Møller, Peter L., Comaposada-Baró, Raquel, Zolkowski, Bartlomiej E., Vieira, Cármen, Jørgensen, Margarita Melnikova, Holm, Ida E., Valdmanis, Paul N., Wellner, Niels, Vægter, Christian B., Lincoln, Sarah J., Nykjær, Anders, Ertekin-Taner, Nilüfer, Young, Jessica E., Nyegaard, Mette, Andersen, Olav M.
Publicado 2021

Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM

por Bashore, Frances M., Katis, Vittorio L., Du, Yuhong, Sikdar, Arunima, Wang, Dongxue, Bradshaw, William J., Rygiel, Karolina A., Leisner, Tina M., Chalk, Rod, Mishra, Swati, Williams, Andrew C., Gileadi, Opher, Brennan, Paul E., Wiley, Jesse C., Gockley, Jake, Cary, Gregory A., Carter, Gregory W., Young, Jessica E., Pearce, Kenneth H., Fu, Haian, Axtman, Alison D.
Publicado 2023

Chromatin establishes an immature version of neuronal protocadherin selection during the naive-to-primed conversion of pluripotent stem cells

por Almenar-Queralt, Angels, Merkurjev, Daria, Kim, Hong Sook, Navarro, Michael, Ma, Qi, Chaves, Rodrigo S., Allegue, Catarina, Driscoll, Shawn P., Chen, Andrew G., Kohlnhofer, Bridget, Fong, Lauren K., Woodruff, Grace, Mackintosh, Carlos, Bohaciakova, Dasa, Hruska-Plochan, Marian, Tadokoro, Takahiro, Young, Jessica E., El Hajj, Nady, Dittrich, Marcus, Marsala, Martin, Goldstein, Lawrence S.B., Garcia-Bassets, Ivan
Publicado 2019

Cell-type-specific regulation of APOE and CLU levels in human neurons by the Alzheimer’s disease risk gene SORL1

por Lee, Hyo, Aylward, Aimee J., Pearse, Richard V., Lish, Alexandra M., Hsieh, Yi-Chen, Augur, Zachary M., Benoit, Courtney R., Chou, Vicky, Knupp, Allison, Pan, Cheryl, Goberdhan, Srilakshmi, Duong, Duc M., Seyfried, Nicholas T., Bennett, David A., Taga, Mariko F., Huynh, Kevin, Arnold, Matthias, Meikle, Peter J., Jager, Philip L. De, Menon, Vilas, Young, Jessica E., Young-Pearse, Tracy L.
Publicado 2023

Use of AD Informer Set compounds to explore validity of novel targets in Alzheimer's disease pathology

por Potjewyd, Frances M., Annor‐Gyamfi, Joel K., Aubé, Jeffrey, Chu, Shaoyou, Conlon, Ivie L., Frankowski, Kevin J., Guduru, Shiva K. R., Hardy, Brian P., Hopkins, Megan D., Kinoshita, Chizuru, Kireev, Dmitri B., Mason, Emily R., Moerk, Charles T., Nwogbo, Felix, Pearce, Kenneth H., Richardson, Timothy I., Rogers, David A., Soni, Disha M., Stashko, Michael, Wang, Xiaodong, Wells, Carrow, Willson, Timothy M., Frye, Stephen V., Young, Jessica E., Axtman, Alison D.
Publicado 2022

AD Informer Set: Chemical tools to facilitate Alzheimer's disease drug discovery

por Potjewyd, Frances M., Annor‐Gyamfi, Joel K., Aubé, Jeffrey, Chu, Shaoyou, Conlon, Ivie L., Frankowski, Kevin J., Guduru, Shiva K. R., Hardy, Brian P., Hopkins, Megan D., Kinoshita, Chizuru, Kireev, Dmitri B., Mason, Emily R., Moerk, Charles T., Nwogbo, Felix, Pearce, Kenneth H., Richardson, Timothy I., Rogers, David A., Soni, Disha M., Stashko, Michael, Wang, Xiaodong, Wells, Carrow, Willson, Timothy M., Frye, Stephen V., Young, Jessica E., Axtman, Alison D.
Publicado 2022

Alternative splicing in a presenilin 2 variant associated with Alzheimer disease

por Braggin, Jacquelyn E., Bucks, Stephanie A., Course, Meredith M., Smith, Carole L., Sopher, Bryce, Osnis, Leah, Shuey, Kiel D., Domoto‐Reilly, Kimiko, Caso, Christina, Kinoshita, Chizuru, Scherpelz, Kathryn P., Cross, Chloe, Grabowski, Thomas, Nik, Seyyed H. M., Newman, Morgan, Garden, Gwenn A., Leverenz, James B., Tsuang, Debby, Latimer, Caitlin, Gonzalez‐Cuyar, Luis F., Keene, Christopher Dirk, Morrison, Richard S., Rhoads, Kristoffer, Wijsman, Ellen M., Dorschner, Michael O., Lardelli, Michael, Young, Jessica E., Valdmanis, Paul N., Bird, Thomas D., Jayadev, Suman
Publicado 2019