Ion Mobility Spectrometry–Mass Spectrometry Defines the Oligomeric Intermediates in Amylin Amyloid Formation and the Mode of Action of Inhibitors

por Young, Lydia M., Cao, Ping, Raleigh, Daniel P., Ashcroft, Alison E., Radford, Sheena E.
Publicado 2013

Understanding co-polymerization in amyloid formation by direct observation of mixed oligomers

por Young, Lydia M., Tu, Ling-Hsien, Raleigh, Daniel P., Ashcroft, Alison E., Radford, Sheena E.
Publicado 2017

Mutational Analysis of the Ability of Resveratrol To Inhibit Amyloid Formation by Islet Amyloid Polypeptide: Critical Evaluation of the Importance of Aromatic–Inhibitor and Histidi...

por Tu, Ling-Hsien, Young, Lydia M., Wong, Amy G., Ashcroft, Alison E., Radford, Sheena E., Raleigh, Daniel P.
Publicado 2014

ESI-IMS–MS: A method for rapid analysis of protein aggregation and its inhibition by small molecules

por Young, Lydia M., Saunders, Janet C., Mahood, Rachel A., Revill, Charlotte H., Foster, Richard J., Ashcroft, Alison E., Radford, Sheena E.
Publicado 2016

A peptide‐display protein scaffold to facilitate single molecule force studies of aggregation‐prone peptides

por Doherty, Ciaran P. A., Young, Lydia M., Karamanos, Theodoros K., Smith, Hugh I., Jackson, Matthew P., Radford, Sheena E., Brockwell, David J.
Publicado 2018

Screening and classifying small molecule inhibitors of amyloid formation using ion mobility spectrometry-mass spectrometry

por Young, Lydia M., Saunders, Janet C., Mahood, Rachel A., Revill, Charlotte H., Foster, Richard J., Tu, Ling-Hsien, Raleigh, Daniel P., Radford, Sheena E., Ashcroft, Alison E.
Publicado 2014

An in vivo platform for identifying inhibitors of protein aggregation

por Saunders, Janet C., Young, Lydia M., Mahood, Rachel A., Jackson, Matthew P., Revill, Charlotte H., Foster, Richard J., Smith, D. Alastair, Ashcroft, Alison E., Brockwell, David J., Radford, Sheena E.
Publicado 2015

Aggregating sequences that occur in many proteins constitute weak spots of bacterial proteostasis

por Khodaparast, Ladan, Khodaparast, Laleh, Gallardo, Rodrigo, Louros, Nikolaos N., Michiels, Emiel, Ramakrishnan, Reshmi, Ramakers, Meine, Claes, Filip, Young, Lydia, Shahrooei, Mohammad, Wilkinson, Hannah, Desager, Matyas, Mengistu Tadesse, Wubishet, Nilsson, K. Peter R., Hammarström, Per, Aertsen, Abram, Carpentier, Sebastien, Van Eldere, Johan, Rousseau, Frederic, Schymkowitz, Joost
Publicado 2018