ANGPTL4 sensitizes lipoprotein lipase to PCSK3 cleavage by catalyzing its unfolding

por Lund Winther, Anne-Marie, Kumari, Anni, Young, Stephen G., Ploug, Michael
Publicado 2021

Circumventing Embryonic Lethality with Lcmt1 Deficiency: Generation of Hypomorphic Lcmt1 Mice with Reduced Protein Phosphatase 2A Methyltransferase Expression and Defects in Insuli...

por MacKay, Kennen B., Tu, Yiping, Young, Stephen G., Clarke, Steven G.
Publicado 2013

Nuclear membrane ruptures, cell death, and tissue damage in the setting of nuclear lamin deficiencies

por Chen, Natalie Y., Kim, Paul H., Fong, Loren G., Young, Stephen G.
Publicado 2020

Revisiting the truncated lamin A produced by a commonly used strain of Lmna knockout mice

por Kim, Joonyoung R., Kim, Paul H., Presnell, Ashley, Tu, Yiping, Young, Stephen G.
Publicado 2023

Nuclear Envelope Protein Lem2 is Required for Mouse Development and Regulates MAP and AKT Kinases

por Tapia, Olga, Fong, Loren G., Huber, Michael D., Young, Stephen G., Gerace, Larry
Publicado 2015

A carboxyl-terminal interaction of lamin B1 is dependent on the CAAX endoprotease Rce1 and carboxymethylation

por Maske, Christopher P., Hollinshead, Michael S., Higbee, Niall C., Bergo, Martin O., Young, Stephen G., Vaux, David J.
Publicado 2003

NanoSIMS imaging of lipid absorption by intestinal enterocytes

por Chen, Kai, Song, Wenxin, Russell, Robert, Ferrari, Alessandra, Darwish, Tamim, Tontonoz, Peter, Young, Stephen G., Jiang, Haibo
Publicado 2022

Assessing the efficacy of protein farnesyltransferase inhibitors in mouse models of progeria

por Yang, Shao H., Chang, Sandy Y., Andres, Douglas A., Spielmann, H. Peter, Young, Stephen G., Fong, Loren G.
Publicado 2010

Mass spectrometry captures off-target drug binding and provides mechanistic insights into the human metalloprotease ZMPSTE24

por Mehmood, Shahid, Marcoux, Julien, Gault, Joseph, Quigley, Andrew, Michaelis, Susan, Young, Stephen G., Carpenter, Elisabeth P., Robinson, Carol V.
Publicado 2016

A protein of capillary endothelial cells, GPIHBP1, is crucial for plasma triglyceride metabolism

por Young, Stephen G., Song, Wenxin, Yang, Ye, Birrane, Gabriel, Jiang, Haibo, Beigneux, Anne P., Ploug, Michael, Fong, Loren G.
Publicado 2022

Slc25a17 Gene Trapped Mice: PMP34 Plays a Role in the Peroxisomal Degradation of Phytanic and Pristanic Acid

por Van Veldhoven, Paul P., de Schryver, Evelyn, Young, Stephen G., Zwijsen, An, Fransen, Marc, Espeel, Marc, Baes, Myriam, Van Ael, Elke
Publicado 2020

Inverse effects of APOC2 and ANGPTL4 on the conformational dynamics of lid-anchoring structures in lipoprotein lipase

por Kumari, Anni, Grønnemose, Anne Louise, Kristensen, Kristian K., Winther, Anne-Marie L., Young, Stephen G., Jørgensen, Thomas J. D., Ploug, Michael
Publicado 2023

Lamin B1 and lamin B2 are long-lived proteins with distinct functions in retinal development

por Razafsky, David, Ward, Candace, Potter, Chloe, Zhu, Wanqiu, Xue, Yunlu, Kefalov, Vladimir J., Fong, Loren G., Young, Stephen G., Hodzic, Didier
Publicado 2016

The angiopoietin-like protein ANGPTL4 catalyzes unfolding of the hydrolase domain in lipoprotein lipase and the endothelial membrane protein GPIHBP1 counteracts this unfolding

por Mysling, Simon, Kristensen, Kristian Kølby, Larsson, Mikael, Kovrov, Oleg, Bensadouen, André, Jørgensen, Thomas JD, Olivecrona, Gunilla, Young, Stephen G, Ploug, Michael
Publicado 2016

Lamin B1 is required for mature neuron-specific gene expression during olfactory sensory neuron differentiation

por Gigante, Crystal M., Dibattista, Michele, Dong, Frederick N., Zheng, Xiaobin, Yue, Sibiao, Young, Stephen G., Reisert, Johannes, Zheng, Yixian, Zhao, Haiqing
Publicado 2017

Evolution and Medical Significance of LU Domain−Containing Proteins

por Leth, Julie Maja, Leth-Espensen, Katrine Zinck, Kristensen, Kristian Kølby, Kumari, Anni, Lund Winther, Anne-Marie, Young, Stephen G., Ploug, Michael
Publicado 2019

GPIHBP1 and ANGPTL4 Utilize Protein Disorder to Orchestrate Order in Plasma Triglyceride Metabolism and Regulate Compartmentalization of LPL Activity

por Kristensen, Kristian Kølby, Leth-Espensen, Katrine Zinck, Kumari, Anni, Grønnemose, Anne Louise, Lund-Winther, Anne-Marie, Young, Stephen G., Ploug, Michael
Publicado 2021

Biventricular adaptation to volume overload in mice with aortic regurgitation

por Berry, Christopher J, Miller, Jordan D, McGroary, KellyAnn, Thedens, Daniel R, Young, Stephen G, Heistad, Donald D, Weiss, Robert M
Publicado 2009

Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion

por Rong, Xin, Wang, Bo, Dunham, Merlow M, Hedde, Per Niklas, Wong, Jinny S, Gratton, Enrico, Young, Stephen G, Ford, David A, Tontonoz, Peter
Publicado 2015

DYT1 Dystonia Patient-Derived Fibroblasts Have Increased Deformability and Susceptibility to Damage by Mechanical Forces

por Gill, Navjot Kaur, Ly, Chau, Kim, Paul H., Saunders, Cosmo A., Fong, Loren G., Young, Stephen G., Luxton, G. W. Gant, Rowat, Amy C.
Publicado 2019