Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer’s disease

por Terzioglu, Gizem, Young-Pearse, Tracy L.
Publicado 2023

Assessment of Spontaneous Neuronal Activity In Vitro Using Multi-Well Multi-Electrode Arrays: Implications for Assay Development

por Negri, Joseph, Menon, Vilas, Young-Pearse, Tracy L.
Publicado 2020

Mosaic loss of Chromosome Y in aged human microglia

por Vermeulen, Michael C., Pearse, Richard, Young-Pearse, Tracy, Mostafavi, Sara
Publicado 2022

Comparison and Optimization of hiPSC Forebrain Cortical Differentiation Protocols

por Muratore, Christina R., Srikanth, Priya, Callahan, Dana G., Young-Pearse, Tracy L.
Publicado 2014

Methods for the isolation and analysis of Aβ from postmortem brain

por Hong, Wei, Liu, Wen, Desousa, Alexandra O., Young-Pearse, Tracy, Walsh, Dominic M.
Publicado 2023

Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1

por Young-Pearse, Tracy L, Chen, Allen C, Chang, Rui, Marquez, Cesar, Selkoe, Dennis J
Publicado 2008

Loss of endosomal exchanger NHE6 leads to pathological changes in tau in human neurons

por Fernandez, Marty A., Bah, Fatmata, Ma, Li, Lee, YouJin, Schmidt, Michael, Welch, Elizabeth, Morrow, Eric M., Young-Pearse, Tracy L.
Publicado 2022

Convergence of independent DISC1 mutations on impaired neurite growth via decreased UNC5D expression

por Srikanth, Priya, Lagomarsino, Valentina N., Pearse, Richard V., Liao, Meichen, Ghosh, Sulagna, Nehme, Ralda, Seyfried, Nicholas, Eggan, Kevin, Young-Pearse, Tracy L.
Publicado 2018

Small Molecule Regulators of microRNAs Identified by High-Throughput Screen Coupled with High-Throughput Sequencing

por Krichevsky, Anna, Nguyen, Lien, Wei, Zhiyun, Silva, M., Barberán-Soler, Sergio, Rabinovsky, Rosalia, Muratore, Christina, Stricker, Jonathan, Hortman, Colin, Young-Pearse, Tracy, Haggarty, Stephen
Publicado 2023

Shared effects of DISC1 disruption and elevated WNT signaling in human cerebral organoids

por Srikanth, Priya, Lagomarsino, Valentina N., Muratore, Christina R., Ryu, Steven C., He, Amy, Taylor, Walter M., Zhou, Constance, Arellano, Marlise, Young-Pearse, Tracy L.
Publicado 2018

Elevated ganglioside GM2 activator (GM2A) in human brain tissue reduces neurite integrity and spontaneous neuronal activity

por Hsieh, Yi-Chen, Negri, Joseph, He, Amy, Pearse, Richard V., Liu, Lei, Duong, Duc M., Chibnik, Lori B., Bennett, David A., Seyfried, Nicholas T., Young-Pearse, Tracy L.
Publicado 2022

Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles

por Guix, Francesc X., Corbett, Grant T., Cha, Diana J., Mustapic, Maja, Liu, Wen, Mengel, David, Chen, Zhicheng, Aikawa, Elena, Young-Pearse, Tracy, Kapogiannis, Dimitrios, Selkoe, Dennis J., Walsh, Dominic M.
Publicado 2018

Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model

por Rice, Heather C., Marcassa, Gabriele, Chrysidou, Iordana, Horré, Katrien, Young-Pearse, Tracy L., Müller, Ulrike C., Saito, Takashi, Saido, Takaomi C., Vassar, Robert, de Wit, Joris, De Strooper, Bart
Publicado 2020

Learnings about Aβ from human brain recommend the use of a live-neuron bioassay for the discovery of next generation Alzheimer’s disease immunotherapeutics

por Wang, Zemin, Jin, Ming, Hong, Wei, Liu, Wen, Reczek, David, Lagomarsino, Valentina N., Hu, Yuan, Weeden, Tim, Frosch, Matthew P., Young-Pearse, Tracy L., Pradier, Laurent, Selkoe, Dennis, Walsh, Dominic M.
Publicado 2023

Cell models of lipid-rich α-synuclein aggregation validate known modifiers of α-synuclein biology and identify stearoyl-CoA desaturase

por Imberdis, Thibaut, Negri, Joseph, Ramalingam, Nagendran, Terry-Kantor, Elizabeth, Ho, Gary P. H., Fanning, Saranna, Stirtz, Georgia, Kim, Tae-Eun, Levy, Oren A., Young-Pearse, Tracy L., Selkoe, Dennis, Dettmer, Ulf
Publicado 2019

An in vitro paradigm to assess potential anti-Aβ antibodies for Alzheimer’s disease

por Jin, Ming, O’Nuallain, Brian, Hong, Wei, Boyd, Justin, Lagomarsino, Valentina N., O’Malley, Tiernan T., Liu, Wen, Vanderburg, Charles R., Frosch, Matthew P., Young-Pearse, Tracy, Selkoe, Dennis J., Walsh, Dominic M.
Publicado 2018

Human neural cell type‐specific extracellular vesicle proteome defines disease‐related molecules associated with activated astrocytes in Alzheimer's disease brain

por You, Yang, Muraoka, Satoshi, Jedrychowski, Mark P., Hu, Jianqiao, McQuade, Amanda K., Young‐Pearse, Tracy, Aslebagh, Roshanak, Shaffer, Scott A., Gygi, Steven P., Blurton‐Jones, Mathew, Poon, Wayne W., Ikezu, Tsuneya
Publicado 2022

Small molecule regulators of microRNAs identified by high-throughput screen coupled with high-throughput sequencing

por Nguyen, Lien D., Wei, Zhiyun, Silva, M. Catarina, Barberán-Soler, Sergio, Zhang, Jiarui, Rabinovsky, Rosalia, Muratore, Christina R., Stricker, Jonathan M. S., Hortman, Colin, Young-Pearse, Tracy L., Haggarty, Stephen J., Krichevsky, Anna M.
Publicado 2023

Predictive network analysis identifies JMJD6 and other potential key drivers in Alzheimer’s disease

por Merchant, Julie P., Zhu, Kuixi, Henrion, Marc Y. R., Zaidi, Syed S. A., Lau, Branden, Moein, Sara, Alamprese, Melissa L., Pearse, Richard V., Bennett, David A., Ertekin-Taner, Nilüfer, Young-Pearse, Tracy L., Chang, Rui
Publicado 2023

Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer’s disease susceptibility

por Raj, Towfique, Li, Yang I., Wong, Garrett, Humphrey, Jack, Wang, Minghui, Ramdhani, Satesh, Wang, Ying-Chih, Ng, Bernard, Gupta, Ishaan, Haroutunian, Vahram, Schadt, Eric E., Young-Pearse, Tracy, Mostafavi, Sara, Zhang, Bin, Sklar, Pamela, Bennett, David A., De Jager, Philip L.
Publicado 2018