Transcriptional gene silencing in mammalian cells by miRNA mimics that target gene promoters

por Younger, Scott T., Corey, David R.
Publicado 2011

p53 regulates enhancer accessibility and activity in response to DNA damage

por Younger, Scott T., Rinn, John L.
Publicado 2017

Identification of functional regulatory elements in the human genome using pooled CRISPR screens

por Borys, Samantha M., Younger, Scott T.
Publicado 2020

CRISPR Display: A modular method for locus-specific targeting of long noncoding RNAs and synthetic RNA devices in vivo

por Shechner, David M., Hacisüleyman, Ezgi, Younger, Scott T., Rinn, John L.
Publicado 2015

Expediting rare disease diagnosis: a call to bridge the gap between clinical and functional genomics

por Hartin, Samantha N., Means, John C., Alaimo, Joseph T., Younger, Scott T.
Publicado 2020

FOXC2 Autoregulates Its Expression in the Pulmonary Endothelium After Endotoxin Stimulation in a Histone Acetylation-Dependent Manner

por Xia, Sheng, Yu, Wei, Menden, Heather, Younger, Scott T., Sampath, Venkatesh
Publicado 2021

Involvement of argonaute proteins in gene silencing and activation by RNAs complementary to a non-coding transcript at the progesterone receptor promoter

por Chu, Yongjun, Yue, Xuan, Younger, Scott T., Janowski, Bethany A., Corey, David R.
Publicado 2010

Integrative genomic analysis reveals widespread enhancer regulation by p53 in response to DNA damage

por Younger, Scott T., Kenzelmann-Broz, Daniela, Jung, Heiyoun, Attardi, Laura D., Rinn, John L.
Publicado 2015

Massively parallel identification of functionally consequential noncoding genetic variants in undiagnosed rare disease patients

por McQuerry, Jasmine A., Mclaird, Merry, Hartin, Samantha N., Means, John C., Johnston, Jeffrey, Pastinen, Tomi, Younger, Scott T.
Publicado 2022

Antisense transcripts are targets for activating small RNAs

por Schwartz, Jacob C, Younger, Scott T, Nguyen, Ngoc-Bich, Hardy, Daniel B, Monia, Brett P, Corey, David R, Janowski, Bethany A
Publicado 2008

Medin Oligomer Membrane Pore Formation: A Potential Mechanism of Vascular Dysfunction

por Younger, Scott, Jang, Hyunbum, Davies, Hannah A., Niemiec, Martin J., Garcia, Joe G.N., Nussinov, Ruth, Migrino, Raymond Q., Madine, Jillian, Arce, Fernando T.
Publicado 2020

Orthologous CRISPR-Cas9 enzymes for Combinatorial Genetic Screens

por Najm, Fadi J, Strand, Christine, Donovan, Katherine F, Hegde, Mudra, Sanson, Kendall R, Vaimberg, Emma W, Sullender, Meagan E, Hartenian, Ella, Kalani, Zohra, Fusi, Nicolo, Listgarten, Jennifer, Younger, Scott T, Bernstein, Bradley E, Root, David E, Doench, John G
Publicado 2017

An In Vivo CRISPR Screening Platform for Prioritizing Therapeutic Targets in AML

por Lin, Shan, Larrue, Clément, Scheidegger, Nastassja K., Seong, Bo Kyung A., Dharia, Neekesh V., Kuljanin, Miljan, Wechsler, Caroline S., Kugener, Guillaume, Robichaud, Amanda L., Conway, Amy Saur, Mashaka, Thelma, Mouche, Sarah, Adane, Biniam, Ryan, Jeremy A., Mancias, Joseph D., Younger, Scott T., Piccioni, Federica, Lee, Lynn H., Wunderlich, Mark, Letai, Anthony, Tamburini, Jérôme, Stegmaier, Kimberly
Publicado 2022

Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets

por Dempster, Joshua M., Pacini, Clare, Pantel, Sasha, Behan, Fiona M., Green, Thomas, Krill-Burger, John, Beaver, Charlotte M., Younger, Scott T., Zhivich, Victor, Najgebauer, Hanna, Allen, Felicity, Gonçalves, Emanuel, Shepherd, Rebecca, Doench, John G., Yusa, Kosuke, Vazquez, Francisca, Parts, Leopold, Boehm, Jesse S., Golub, Todd R., Hahn, William C., Root, David E., Garnett, Mathew J., Tsherniak, Aviad, Iorio, Francesco
Publicado 2019

SMAD4 represses FOSL1 expression and pancreatic cancer metastatic colonization

por Dai, Chao, Rennhack, Jonathan P., Arnoff, Taylor E., Thaker, Maneesha, Younger, Scott T., Doench, John G., Huang, August Yue, Yang, Annan, Aguirre, Andrew J., Wang, Belinda, Mun, Evan, O’Connell, Joyce T., Huang, Ying, Labella, Katherine, Talamas, Jessica A., Li, Ji, Ilic, Nina, Hwang, Justin, Hong, Andrew L., Giacomelli, Andrew O., Gjoerup, Ole, Root, David E., Hahn, William C.
Publicado 2021

Direct haplotype-resolved 5-base HiFi sequencing for genome-wide profiling of hypermethylation outliers in a rare disease cohort

por Cheung, Warren A., Johnson, Adam F., Rowell, William J., Farrow, Emily, Hall, Richard, Cohen, Ana S. A., Means, John C., Zion, Tricia N., Portik, Daniel M., Saunders, Christopher T., Koseva, Boryana, Bi, Chengpeng, Truong, Tina K., Schwendinger-Schreck, Carl, Yoo, Byunggil, Johnston, Jeffrey J., Gibson, Margaret, Evrony, Gilad, Rizzo, William B., Thiffault, Isabelle, Younger, Scott T., Curran, Tom, Wenger, Aaron M., Grundberg, Elin, Pastinen, Tomi
Publicado 2023