Integrated Safety Assessment of 2′-O-Methoxyethyl Chimeric Antisense Oligonucleotides in NonHuman Primates and Healthy Human Volunteers

por Crooke, Stanley T, Baker, Brenda F, Kwoh, T Jesse, Cheng, Wei, Schulz, Dan J, Xia, Shuting, Salgado, Nelson, Bui, Huynh-Hoa, Hart, Christopher E, Burel, Sebastien A, Younis, Husam S, Geary, Richard S, Henry, Scott P, Bhanot, Sanjay
Publicado 2016

Targeted tissue delivery of RNA therapeutics using antibody–oligonucleotide conjugates (AOCs)

por Malecova, Barbora, Burke, Rob S, Cochran, Michael, Hood, Michael D, Johns, Rachel, Kovach, Philip R, Doppalapudi, Venkata R, Erdogan, Gulin, Arias, J Danny, Darimont, Beatrice, Miller, Christopher D, Huang, Hanhua, Geall, Andrew, Younis, Husam S, Levin, Arthur A
Publicado 2023

Hepatotoxicity of high affinity gapmer antisense oligonucleotides is mediated by RNase H1 dependent promiscuous reduction of very long pre-mRNA transcripts

por Burel, Sebastien A., Hart, Christopher E., Cauntay, Patrick, Hsiao, Jill, Machemer, Todd, Katz, Melanie, Watt, Andy, Bui, Huynh-hoa, Younis, Husam, Sabripour, Mahyar, Freier, Susan M., Hung, Gene, Dan, Amy, Prakash, T.P., Seth, Punit P., Swayze, Eric E., Bennett, C. Frank, Crooke, Stanley T., Henry, Scott P.
Publicado 2016