New Anticancer Theobromine Derivative Targeting EGFR(WT) and EGFR(T790M): Design, Semi-Synthesis, In Silico, and In Vitro Anticancer Studies

por Elkaeed, Eslam B., Yousef, Reda G., Elkady, Hazem, Alsfouk, Aisha A., Husein, Dalal Z., Ibrahim, Ibrahim M., Metwaly, Ahmed M., Eissa, Ibrahim H.
Publicado 2022

Anticancer derivative of the natural alkaloid, theobromine, inhibiting EGFR protein: Computer-aided drug discovery approach

por Eissa, Ibrahim H., Yousef, Reda G., Elkaeed, Eslam B., Alsfouk, Aisha A., Husein, Dalal Z., Ibrahim, Ibrahim M., Alesawy, Mohamed S., Elkady, Hazem, Metwaly, Ahmed M.
Publicado 2023

A Theobromine Derivative with Anticancer Properties Targeting VEGFR‐2: Semisynthesis, in silico and in vitro Studies

por Eissa, Ibrahim H., Yousef, Reda G., Elkady, Hazem, Elkaeed, Eslam B., Alsfouk, Aisha A., Husein, Dalal Z., Ibrahim, Ibrahim M., Radwan, Mohamed M., Metwaly, Ahmed M.
Publicado 2023

A New Anticancer Semisynthetic Theobromine Derivative Targeting EGFR Protein: CADDD Study

por Eissa, Ibrahim H., Yousef, Reda G., Elkady, Hazem, Alsfouk, Aisha A., Alsfouk, Bshra A., Husein, Dalal Z., Ibrahim, Ibrahim M., Elkaeed, Eslam B., Metwaly, Ahmed M.
Publicado 2023

Computer-Assisted Drug Discovery of a Novel Theobromine Derivative as an EGFR Protein-Targeted Apoptosis Inducer

por Eissa, Ibrahim H, Yousef, Reda G, Elkaeed, Eslam B, Alsfouk, Aisha A, Husein, Dalal Z, Ibrahim, Ibrahim M, El-Mahdy, Hesham A, Elkady, Hazem, Metwaly, Ahmed M
Publicado 2023

Inhibition of Vascular Smooth Muscle and Cancer Cell Proliferation by New VEGFR Inhibitors and Their Immunomodulator Effect: Design, Synthesis, and Biological Evaluation

por Ran, Feng, Li, Wendong, Qin, Yi, Yu, Tong, Liu, Zhao, Zhou, Min, Liu, Cheng, Qiao, Tong, Li, Xiaoqiang, Yousef, Reda G., Eissa, Ibrahim H., Khalifa, Mohamed M.
Publicado 2021

Design, Synthesis, Docking, DFT, MD Simulation Studies of a New Nicotinamide-Based Derivative: In Vitro Anticancer and VEGFR-2 Inhibitory Effects

por Elkaeed, Eslam B., Yousef, Reda G., Elkady, Hazem, Gobaara, Ibraheem M. M., Alsfouk, Bshra A., Husein, Dalal Z., Ibrahim, Ibrahim M., Metwaly, Ahmed M., Eissa, Ibrahim H.
Publicado 2022

Identification of new theobromine-based derivatives as potent VEGFR-2 inhibitors: design, semi-synthesis, biological evaluation, and in silico studies

por Eissa, Ibrahim H., Yousef, Reda G., Elkady, Hazem, Elkaeed, Eslam B., Alsfouk, Aisha A., Husein, Dalal Z., Ibrahim, Ibrahim M., Elhendawy, Mostafa A., Godfrey, Murrell, Metwaly, Ahmed M.
Publicado 2023

(E)-N-(3-(1-(2-(4-(2,2,2-Trifluoroacetamido)benzoyl)hydrazono)ethyl)phenyl)nicotinamide: A Novel Pyridine Derivative for Inhibiting Vascular Endothelial Growth Factor Receptor-2: S...

por Yousef, Reda G., Elkady, Hazem, Elkaeed, Eslam B., Gobaara, Ibraheem M. M., Al-ghulikah, Hanan A., Husein, Dalal Z., Ibrahim, Ibrahim M., Metwaly, Ahmed M., Eissa, Ibrahim H.
Publicado 2022

Computer-assisted drug discovery (CADD) of an anti-cancer derivative of the theobromine alkaloid inhibiting VEGFR-2

por Eissa, Ibrahim H., Yousef, Reda G., Asmaey, Mostafa A., Elkady, Hazem, Husein, Dalal Z., Alsfouk, Aisha A., Ibrahim, Ibrahim M., Elkady, Mohamed A., Elkaeed, Eslam B., Metwaly, Ahmed M.
Publicado 2023

Design, Synthesis, In Silico and In Vitro Studies of New Immunomodulatory Anticancer Nicotinamide Derivatives Targeting VEGFR-2

por Yousef, Reda G., Eldehna, Wagdy M., Elwan, Alaa, Abdelaziz, Abdelaziz S., Mehany, Ahmed B. M., Gobaara, Ibraheem M. M., Alsfouk, Bshra A., Elkaeed, Eslam B., Metwaly, Ahmed M., Eissa, Ibrahim H.
Publicado 2022

Discovery of new nicotinamides as apoptotic VEGFR-2 inhibitors: virtual screening, synthesis, anti-proliferative, immunomodulatory, ADMET, toxicity, and molecular dynamic simulatio...

por Yousef, Reda G., Ibrahim, Albaraa, Khalifa, Mohamed M., Eldehna, Wagdy M., Gobaara, Ibraheem M. M., Mehany, Ahmed B. M., Elkaeed, Eslam B., Alsfouk, Aisha A., Metwaly, Ahmed M., Eissa, Ibrahim H.
Publicado 2022

Anti-cancer and immunomodulatory evaluation of new nicotinamide derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: in vitro and in silico studies

por Yousef, Reda G., Elwan, Alaa, Gobaara, Ibraheem M. M., Mehany, Ahmed B. M., Eldehna, Wagdy M., El-Metwally, Souad A., A. Alsfouk, Bshra, Elkaeed, Eslam B., Metwaly, Ahmed M., Eissa, Ibrahim H.
Publicado 2022

Discovery of New VEGFR-2 Inhibitors: Design, Synthesis, Anti-Proliferative Evaluation, Docking, and MD Simulation Studies

por Elkaeed, Eslam B., Yousef, Reda G., Khalifa, Mohamed M., Ibrahim, Albaraa, Mehany, Ahmed B. M., Gobaara, Ibraheem M. M., Alsfouk, Bshra A., Eldehna, Wagdy M., Metwaly, Ahmed M., Eissa, Ibrahim H., El-Zahabi, Mohamed Ayman
Publicado 2022