Editorial: Pharmaceutical insights into the triazoles: Recent advances

por Deng, Xianqing, Sun, Haopeng, Youssif, Bahaa G. M.
Publicado 2023

Globally Approved EGFR Inhibitors: Insights into Their Syntheses, Target Kinases, Biological Activities, Receptor Interactions, and Metabolism

por Abourehab, Mohammed A. S., Alqahtani, Alaa M., Youssif, Bahaa G. M., Gouda, Ahmed M.
Publicado 2021

One-Pot Synthesis of 1-Thia-4-azaspiro[4.4/5]alkan-3-ones via Schiff Base: Design, Synthesis, and Apoptotic Antiproliferative Properties of Dual EGFR/BRAF(V600E) Inhibitors

por Al-Wahaibi, Lamya H., El-Sheref, Essmat M., Hammouda, Mohamed M., Youssif, Bahaa G. M.
Publicado 2023

Design, Synthesis, and Biological Evaluation of Indole-2-carboxamides as Potential Multi-Target Antiproliferative Agents

por Al-Wahaibi, Lamya H., Mohammed, Anber F., Abdelrahman, Mostafa H., Trembleau, Laurent, Youssif, Bahaa G. M.
Publicado 2023

Synthesis, Antioxidant and Antiproliferative Actions of 4-(1,2,3-Triazol-1-yl)quinolin-2(1H)-ones as Multi-Target Inhibitors

por El-Sheref, Essmat M., Bräse, Stefan, Tawfeek, Hendawy N., Alasmary, Fatmah Ali, Youssif, Bahaa G. M.
Publicado 2023

Design, Synthesis, and Antiproliferative Activity of New 5-Chloro-indole-2-carboxylate and Pyrrolo[3,4-b]indol-3-one Derivatives as Potent Inhibitors of EGFR(T790M)/BRAF(V600E) Pat...

por Al-Wahaibi, Lamya H., Mohammed, Anber F., Abdelrahman, Mostafa H., Trembleau, Laurent, Youssif, Bahaa G. M.
Publicado 2023

Novel piperine-carboximidamide hybrids: design, synthesis, and antiproliferative activity via a multi-targeted inhibitory pathway

por Al-Wahaibi, Lamya H., Mahmoud, Mohamed A., Mostafa, Yaser A., Raslan, Ali E., Youssif, Bahaa G. M.
Publicado 2022

New 1,2,3-Triazole/1,2,4-triazole Hybrids as Aromatase Inhibitors: Design, Synthesis, and Apoptotic Antiproliferative Activity

por Maghraby, Mohamed T-E, Mazyad Almutairi, Tahani, Bräse, Stefan, Salem, Ola I. A., Youssif, Bahaa G. M., Sheha, Mahmoud M.
Publicado 2023

Design, Synthesis, Biological Evaluation, and Computational Studies of Novel Tri-Aryl Imidazole-Benzene Sulfonamide Hybrids as Promising Selective Carbonic Anhydrase IX and XII Inh...

por Al-Wahaibi, Lamya H., Youssif, Bahaa G. M., Taher, Ehab S., Abdelazeem, Ahmed H., Abdelhamid, Antar A., Marzouk, Adel A.
Publicado 2021

Design, Synthesis, and Anti-Proliferative Action of Purine/Pteridine-Based Derivatives as Dual Inhibitors of EGFR and BRAF(V600E)

por El-Kalyoubi, Samar A., Gomaa, Hesham A. M., Abdelhafez, Elshimaa M. N., Ramadan, Mohamed, Agili, Fatimah, Youssif, Bahaa G. M.
Publicado 2023

Synthesis and Biological Evaluation of Indole-2-Carboxamides with Potent Apoptotic Antiproliferative Activity as EGFR/CDK2 Dual Inhibitors

por Al-Wahaibi, Lamya H., Mostafa, Yaser A., Abdelrahman, Mostafa H., El-Bahrawy, Ali H., Trembleau, Laurent, Youssif, Bahaa G. M.
Publicado 2022

Design, Synthesis, and Antibacterial Screening of Some Novel Heteroaryl-Based Ciprofloxacin Derivatives as DNA Gyrase and Topoisomerase IV Inhibitors

por Al-Wahaibi, Lamya H., Amer, Amer A., Marzouk, Adel A., Gomaa, Hesham A. M., Youssif, Bahaa G. M., Abdelhamid, Antar A.
Publicado 2021

Design, Synthesis, Antiproliferative Actions, and DFT Studies of New Bis–Pyrazoline Derivatives as Dual EGFR/BRAF(V600E) Inhibitors

por Al-Wahaibi, Lamya H., Abou-Zied, Hesham A., Beshr, Eman A. M., Youssif, Bahaa G. M., Hayallah, Alaa M., Abdel-Aziz, Mohamed
Publicado 2023

Chalcone/1,3,4-Oxadiazole/Benzimidazole hybrids as novel anti-proliferative agents inducing apoptosis and inhibiting EGFR & BRAFV(600E)

por Hagar, Fatma Fouad, Abbas, Samar H., Gomaa, Hesham A. M., Youssif, Bahaa G. M., Sayed, Ahmed M., Abdelhamid, Dalia, Abdel-Aziz, Mohamed
Publicado 2023

Design, synthesis, apoptotic, and antiproliferative effects of 5-chloro-3- (2-methoxyvinyl)-indole-2-carboxamides and pyrido[3,4-b]indol-1-ones as potent EGFR(WT/)EGFR(T790M) inhib...

por Al-Wahaibi, Lamya H., Mohammed, Anber F., Abdel Rahman, Fatema El-Zahraa S., Abdelrahman, Mostafa H., Gu, Xuyuan, Trembleau, Laurent, Youssif, Bahaa G. M.
Publicado 2023

Structure-based design, synthesis, and biological evaluation of novel piperine–resveratrol hybrids as antiproliferative agents targeting SIRT-2

por Tantawy, Ahmed H., Meng, Xiang-Gao, Marzouk, Adel A., Fouad, Ali, Abdelazeem, Ahmed H., Youssif, Bahaa G. M., Jiang, Hong, Wang, Man-Qun
Publicado 2021

Design and Synthesis of (2-oxo-1,2-Dihydroquinolin-4-yl)-1,2,3-triazole Derivatives via Click Reaction: Potential Apoptotic Antiproliferative Agents

por El-Sheref, Essmat M., Elbastawesy, Mohammed A. I., Brown, Alan B., Shawky, Ahmed M., Gomaa, Hesham A. M., Bräse, Stefan, Youssif, Bahaa G. M.
Publicado 2021

Design and synthesis of new thiazolidinone/uracil derivatives as antiproliferative agents targeting EGFR and/or BRAF(V600E)

por Alshammari, Mohammed B., Aly, Ashraf A., Youssif, Bahaa G. M., Bräse, Stefan, Ahmad, Akil, Brown, Alan B., Ibrahim, Mahmoud A. A., Mohamed, Asmaa H.
Publicado 2022

Synthesis and Structure Determination of Substituted Thiazole Derivatives as EGFR/BRAF(V600E) Dual Inhibitors Endowed with Antiproliferative Activity

por Al-Wahaibi, Lamya H., El-Sheref, Essmat M., Hassan, Alaa A., Bräse, S., Nieger, M., Youssif, Bahaa G. M., Ibrahim, Mahmoud A. A., Tawfeek, Hendawy N.
Publicado 2023

Quinazolin-4-one/3-cyanopyridin-2-one Hybrids as Dual Inhibitors of EGFR and BRAF(V600E): Design, Synthesis, and Antiproliferative Activity

por Al-Wahaibi, Lamya H., Hisham, Mohamed, Abou-Zied, Hesham A., Hassan, Heba A., Youssif, Bahaa G. M., Bräse, Stefan, Hayallah, Alaa M., Abdel-Aziz, Mohamed
Publicado 2023