Analgesic effects and pharmacologic mechanisms of the Gelsemium alkaloid koumine on a rat model of postoperative pain

por Xiong, Bo-Jun, Xu, Ying, Jin, Gui-Lin, Liu, Ming, Yang, Jian, Yu, Chang-Xi
Publicado 2017

Koumine Decreases Astrocyte-Mediated Neuroinflammation and Enhances Autophagy, Contributing to Neuropathic Pain From Chronic Constriction Injury in Rats

por Jin, Gui-lin, Yue, Rong-cai, He, Sai-di, Hong, Li-mian, Xu, Ying, Yu, Chang-xi
Publicado 2018

Koumine enhances spinal cord 3α-hydroxysteroid oxidoreductase expression and activity in a rat model of neuropathic pain

por Qiu, Hong-Qiang, Xu, Ying, Jin, Gui-Lin, Yang, Jian, Liu, Ming, Li, Su-Ping, Yu, Chang-Xi
Publicado 2015

D-Optimal Design and Development of a Koumine-Loaded Microemulsion for Rheumatoid Arthritis Treatment: In vivo and in vitro Evaluation

por Hu, Qing, Fu, Xiao-Ling, Dong, Yi-Yan, Ma, Ju, Hua, Jian, Li, Jia-Ting, Liu, Kai-Xin, Yang, Jian, Yu, Chang-Xi
Publicado 2023

Orally Administered Koumine Persists Longer in the Plasma of Aged Rats Than That of Adult Rats as Assessed by Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry

por Ye, Li-Xiang, Xu, Ying, Zhang, Shui-Hua, Cao, Da-Xuan, Chen, Ling-Fan, Su, Yan-Ping, Huang, Hui-Hui, Yu, Chang-Xi
Publicado 2020

Koumine Attenuates Neuroglia Activation and Inflammatory Response to Neuropathic Pain

por Jin, Gui-Lin, He, Sai-Di, Lin, Shao-Mei, Hong, Li-Mian, Chen, Wan-Qing, Xu, Ying, Yang, Jian, Li, Su-Ping, Yu, Chang-Xi
Publicado 2018

SYVN1, an ERAD E3 Ubiquitin Ligase, Is Involved in GABA(A)α1 Degradation Associated with Methamphetamine-Induced Conditioned Place Preference

por Jiao, Dong-Liang, Chen, Yan, Liu, Yao, Ju, Yun-Yue, Long, Jian-Dong, Du, Jiang, Yu, Chang-Xi, Wang, Yu-Jun, Zhao, Min, Liu, Jing-Gen
Publicado 2017

Streptozotocin-Induced Hyperglycemia Affects the Pharmacokinetics of Koumine and its Anti-Allodynic Action in a Rat Model of Diabetic Neuropathic Pain

por Ye, Li-Xiang, Huang, Hui-Hui, Zhang, Shui-Hua, Lu, Jing-Shan, Cao, Da-Xuan, Wu, Dan-Dan, Chi, Pei-Wang, Hong, Long-Hui, Wu, Min-Xia, Xu, Ying, Yu, Chang-Xi
Publicado 2021