The obligatory role of Activin A in the formation of heterotopic bone in Fibrodysplasia Ossificans Progressiva

por Wolken, Dana M. Alessi, Idone, Vincent, Hatsell, Sarah J., Yu, Paul B., Economides, Aris N.
Publicado 2017

Wnt Inhibitors Dkk1 and Sost Are Downstream Targets of BMP Signaling Through the Type IA Receptor (BMPRIA) in Osteoblasts

por Kamiya, Nobuhiro, Kobayashi, Tatsuya, Mochida, Yoshiyuki, Yu, Paul B, Yamauchi, Mitsuo, Kronenberg, Henry M, Mishina, Yuji
Publicado 2010

Generation of an induced pluripotent stem cell line (TRNDi012-B) from Fibrodysplasia Ossificans Progressiva (FOP) patient carrying a heterozygous mutation c. 617G > A in the ACVR1...

por Huang, Xiuli, Roeder, Amanda, Li, Rong, Beers, Jeanette, Liu, Chengyu, Zou, Jizhong, Yu, Paul B., Zheng, Wei
Publicado 2021

Suppressed prefrontal cortex oscillations associate with clinical pain in fibrodysplasia ossificans progressiva

por Peng, Ke, Karunakaran, Keerthana Deepti, Labadie, Robert, Veliu, Miranda, Cheung, Chandler, Lee, Arielle, Yu, Paul B., Upadhyay, Jaymin
Publicado 2021

Diminished muscle integrity in patients with fibrodysplasia ossificans progressiva assessed with at-home electrical impedance myography

por Farid, Alexander, Golden, Emma, Robicheau, Sara, Hu, Alice, Cheung, Kin, Yu, Paul B., Rutkove, Seward B., Upadhyay, Jaymin
Publicado 2022

Hepcidin Regulation by BMP Signaling in Macrophages Is Lipopolysaccharide Dependent

por Wu, Xinggang, Yung, Lai-Ming, Cheng, Wai-Hang, Yu, Paul B., Babitt, Jodie L., Lin, Herbert Y., Xia, Yin
Publicado 2012

Perspectives on Cardiopulmonary Critical Care for Patients With COVID‐19: From Members of the American Heart Association Council on Cardiopulmonary, Critical Care, Perioperative an...

por Maron, Bradley A., Gladwin, Mark T., Bonnet, Sebastien, De Jesus Perez, Vinicio, Perman, Sarah M., Yu, Paul B., Ichinose, Fumito
Publicado 2020

Bone Morphogenetic Protein-2 Induces Non-Canonical Inflammatory and Oxidative Pathways in Human Retinal Endothelial Cells

por Al-Shabrawey, Mohamed, Hussein, Khaled, Wang, Fang, Wan, Ming, Elmasry, Khaled, Elsherbiny, Nehal, Saleh, Heba, Yu, Paul B., Tawfik, Amany, Ibrahim, Ahmed S.
Publicado 2021

Structure–Activity Relationship of 3,5-Diaryl-2-aminopyridine ALK2 Inhibitors Reveals Unaltered Binding Affinity for Fibrodysplasia Ossificans Progressiva Causing Mutants

por Mohedas, Agustin H., Wang, You, Sanvitale, Caroline E., Canning, Peter, Choi, Sungwoon, Xing, Xuechao, Bullock, Alex N., Cuny, Gregory D., Yu, Paul B.
Publicado 2014

Isolating pulmonary microvascular endothelial cells ex vivo: Implications for pulmonary arterial hypertension, and a caution on the use of commercial biomaterials

por Wertheim, Bradley M., Lin, Yi-Dong, Zhang, Ying-Yi, Samokhin, Andriy O., Alba, George A., Arons, Elena, Yu, Paul B., Maron, Bradley A.
Publicado 2019

Dorsomorphin, a Selective Small Molecule Inhibitor of BMP Signaling, Promotes Cardiomyogenesis in Embryonic Stem Cells

por Hao, Jijun, Daleo, Marie A., Murphy, Clare K., Yu, Paul B., Ho, Joshua N., Hu, Jianyong, Peterson, Randall T., Hatzopoulos, Antonis K., Hong, Charles C.
Publicado 2008

Protocol paper: a multi-center, double-blinded, randomized, 6-month, placebo-controlled study followed by 12-month open label extension to evaluate the safety and efficacy of Sarac...

por Smilde, Bernard J., Stockklausner, Clemens, Keen, Richard, Whittaker, Andrew, Bullock, Alex N., von Delft, Annette, van Schoor, Natasja M., Yu, Paul B., Eekhoff, E. Marelise W.
Publicado 2022

Application of in vitro Drug Metabolism Studies in Chemical Structure Optimization for the Treatment of Fibrodysplasia Ossificans Progressiva (FOP)

por Padilha, Elias C., Wang, Jianyao, Kerns, Ed, Lee, Arthur, Huang, Wenwei, Jiang, Jian-kang, McKew, John, Mutlib, Abdul, Peccinini, Rosangela G., Yu, Paul B., Sanderson, Philip, Xu, Xin
Publicado 2019

A New Class of Small Molecule Inhibitor of BMP Signaling

por Sanvitale, Caroline E., Kerr, Georgina, Chaikuad, Apirat, Ramel, Marie-Christine, Mohedas, Agustin H., Reichert, Sabine, Wang, You, Triffitt, James T., Cuny, Gregory D., Yu, Paul B., Hill, Caroline S., Bullock, Alex N.
Publicado 2013

Circulating angiogenic modulatory factors predict survival and functional class in pulmonary arterial hypertension

por Malhotra, Rajeev, Paskin-Flerlage, Samuel, Zamanian, Roham T., Zimmerman, Patrick, Schmidt, Jonathan W., Deng, Donna Y., Southwood, Mark, Spencer, Robert, Lai, Carol S., Parker, William, Channick, Richard N., Morrell, Nicholas W., Elliott, C. Gregory, Yu, Paul B.
Publicado 2013

Exacerbated inflammatory signaling underlies aberrant response to BMP9 in pulmonary arterial hypertension lung endothelial cells

por Szulcek, Robert, Sanchez-Duffhues, Gonzalo, Rol, Nina, Pan, Xiaoke, Tsonaka, Roula, Dickhoff, Chris, Yung, Lai Ming, Manz, Xue D., Kurakula, Kondababu, Kiełbasa, Szymon M., Mei, Hailiang, Timens, Wim, Yu, Paul B., Bogaard, Harm-Jan, Goumans, Marie-José
Publicado 2020

Inhibition of bone morphogenetic protein 6 receptors ameliorates Sjögren’s syndrome in mice

por Yin, Hongen, Kalra, Lovika, Lai, Zhennan, Guimaro, Maria C., Aber, Lauren, Warner, Blake M., Michael, Drew, Zhang, Nan, Cabrera-Perez, Javier, Karim, Arif, Swaim, William D., Afione, Sandra, Voigt, Alexandria, Nguyen, Cuong Q., Yu, Paul B., Bloch, Donald B., Chiorini, John A.
Publicado 2020

Saracatinib is an efficacious clinical candidate for fibrodysplasia ossificans progressiva

por Williams, Eleanor, Bagarova, Jana, Kerr, Georgina, Xia, Dong-Dong, Place, Elsie S., Dey, Devaveena, Shen, Yue, Bocobo, Geoffrey A., Mohedas, Agustin H., Huang, Xiuli, Sanderson, Philip E., Lee, Arthur, Zheng, Wei, Economides, Aris N., Smith, James C., Yu, Paul B., Bullock, Alex N.
Publicado 2021

Inhibition of Bone Morphogenetic Protein Signal Transduction Prevents the Medial Vascular Calcification Associated with Matrix Gla Protein Deficiency

por Malhotra, Rajeev, Burke, Megan F., Martyn, Trejeeve, Shakartzi, Hannah R., Thayer, Timothy E., O’Rourke, Caitlin, Li, Pingcheng, Derwall, Matthias, Spagnolli, Ester, Kolodziej, Starsha A., Hoeft, Konrad, Mayeur, Claire, Jiramongkolchai, Pawina, Kumar, Ravindra, Buys, Emmanuel S., Yu, Paul B., Bloch, Kenneth D., Bloch, Donald B.
Publicado 2015

A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation

por Kim, Jung-Min, Yang, Yeon-Suk, Park, Kwang Hwan, Ge, Xianpeng, Xu, Ren, Li, Na, Song, Minkyung, Chun, Hyunho, Bok, Seoyeon, Charles, Julia F., Filhol-Cochet, Odile, Boldyreff, Brigitte, Dinter, Teresa, Yu, Paul B., Kon, Ning, Gu, Wei, Takarada, Takeshi, Greenblatt, Matthew B., Shim, Jae-Hyuck
Publicado 2020